- Impact of Hydrogen Peroxide on the Activity, Structure, and Conformational Stability of the Oxidized Protein Repair Enzyme Methionine Sulfoxide Reductase A
[作者:Le, HT; Chaffotte, AF; Demey-Thomas, E; Vinh, J; Friguet, B; Mary, J,期刊:Journal of Molecular Biology, 页码:58-66 , 文章类型: Article,,卷期:2009年393-1]
- The oxidized protein repair methionine sulfoxide reductase (Msr) system has been implicated in aging, in longevity, and in the protection against oxidative stress. This system is made of two different enzymes (MsrA and M...
- A C-Terminal Phosphatase Module Conserved in Vertebrate CMP-Sialic Acid Synthetases Provides a Tetramerization Interface for the Physiologically Active Enzyme
[作者:Oschlies, M; Dickmanns, A; Haselhorst, T; Schaper, W; Stummeyer, K; Tiralongo, J; Weinhold, B; Gerardy-Schahn, R; von Itzstein, M; Ficner, R; Munster-Kuhnel, AK,期刊:Journal of Molecular Biology, 页码:83-97 , 文章类型: Article,,卷期:2009年393-1]
- The biosynthesis of sialic acid-containing glycoconjugates is crucial for the development of vertebrate life. Cytidine monophosphate-sialic acid synthetase (CSS) catalyzes the metabolic activation of sialic acids. In ver...
- On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family
[作者:Pingoud, V; Wende, W; Friedhoff, P; Reuter, M; Alves, J; Jeltsch, A; Mones, L; Fuxreiter, M; Pingoud, A,期刊:Journal of Molecular Biology, 页码:140-160 , 文章类型: Review,,卷期:2009年393-1]
- Restriction endonucleases of the PD...D/EXK family need Mg2+ for DNA cleavage. Whereas Mg2+ (or Mn2+) promotes catalysis, Ca2+ (without Mg2+) only supports DNA binding. The role of Mg2+ in DNA cleavage by restriction end...
- Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy
[作者:Khunrae, P; Philip, JMD; Bull, DR; Higgins, MK,期刊:Journal of Molecular Biology, 页码:202-213 , 文章类型: Article,,卷期:2009年393-1]
- Severe malaria during pregnancy is associated with accumulation of parasite-infected erythrocytes in the placenta due to interactions between VAR2CSA protein, expressed on the surface of infected-erythrocytes, and placen...
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