- Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin
[作者:Xie, ZP; Liu, X; Jia, WT; Zhang, CQ; Huang, WH; Wang, JQ,期刊:Journal of controlled release, 页码:118-126 , 文章类型: Article,,卷期:2009年139-2]
- The effectiveness of a degradable and bioactive borate glass has been compared with the clinically used calcium sulfate in the treatment of osteomyelitis of rabbits, as a carrier for vancomycin. The bone infections were ...
- A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
[作者:Hatakeyama, H; Ito, E; Akita, H; Oishi, M; Nagasaki, Y; Futaki, S; Harashima, H,期刊:Journal of controlled release, 页码:127-132 , 文章类型: Article,,卷期:2009年139-2]
- Previously, we developed a multifunctional envelope-type nano device (MEND) for efficient delivery of both pDNA and siRNA. Modification of a MEND with polyuethylene glycol, i.e., PEGylation, is a potential strategy for i...
- Protein kinase C alpha-specific peptide substrate graft-type copolymer for cancer cell-specific gene regulation systems
[作者:Toita, R; Kang, JH; Kim, JH; Tomiyama, T; Mori, T; Niidome, T; Jun, B; Katayama, Y,期刊:Journal of controlled release, 页码:133-139 , 文章类型: Article,,卷期:2009年139-2]
We recently proposed a novel gene regulation system responding to specifically and abnormally activated intracellular enzymes in diseased cells. In the present study, we focused on protein kinase C(PKC)alpha, which is...
- Preparation and characterization of chitosan/polyguluronate nanoparticles for siRNA delivery
[作者:Lee, DW; Yun, KS; Ban, HS; Choe, W; Lee, SK; Lee, KY,期刊:Journal of controlled release, 页码:146-152 , 文章类型: Article,,卷期:2009年139-2]
- Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, the use of siRNA is limited due to its rapid degradation and low intracellular association...
- DNA tattoo vaccination: Effect on plasmid purity and transfection efficiency of different topoisoforms
[作者:Quaak, SGL; van den Berg, JH; Oosterhuis, K; Beijnen, JH; Haanen, JBAG; Nuijen, B,期刊:Journal of controlled release, 页码:153-159 , 文章类型: Article,,卷期:2009年139-2]
- Recently, DNA tattooing was introduced as novel intradermal administration technique for plasmid DNA (pDNA) vaccines. The aim of this study was to determine if tattooing affects the integrity of pDNA (reduction in superc...
- Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug
[作者:Song, WX; He, Q; Mohwald, H; Yang, Y; Li, JB,期刊:Journal of controlled release, 页码:160-166 , 文章类型: Article,,卷期:2009年139-2]
- Heat treatment is introduced as a simple method for the encapsulation of low molecular weight water-soluble drugs within layer-by-layer assembled microcapsules. A water-soluble drug, procainamide hydrochloride, could thu...
|