- Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites
[作者:Wolinsky, JB; Liu, R; Walpole, J; Chirieac, LR; Colson, YL; Grinstaff, MW,期刊:Journal of controlled release, 页码:280-287 , 文章类型: Article,,卷期:2010年144-3]
- Local tumor recurrence has a major impact on long-term patient survival following the surgical treatment of most cancers, and this is especially true with lung cancer. Consequently, methods to deliver chemotherapeutics l...
- Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model
[作者:Hitchcock, KE; Caudell, DN; Sutton, JT; Klegerman, ME; Vela, D; Pyne-Geithman, GJ; Abruzzo, T; Cyr, PEP; Geng, YJ; McPherson, DD; Holland, CK,期刊:Journal of controlled release, 页码:288-295 , 文章类型: Article,,卷期:2010年144-3]
- The goal of this study was to determine whether targeted, Rhodamine-labeled echogenic liposomes (Rh-ELIP) containing nanobubbles could be delivered to the arterial wall, and whether 1-MHz continuous wave ultrasound would...
- The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery
[作者:Ackaert, OW; De Graan, J; Capancioni, R; Della Pasqua, OE; Dijkstra, D; Westerink, BH; Danhof, M; Bouwstra, JA,期刊:Journal of controlled release, 页码:296-305 , 文章类型: Article,,卷期:2010年144-3]
- The feasibility of transdermal iontophoretic transport of 4 novel ester prodrugs of 5-OH-DPAT (glycine-, proline-, valine- and (beta-alanine-5-OH-DPAT) was investigated in vitro and in vivo. Based on the chemical stabili...
- Gene silencing efficiency of siRNA-PEG conjugates: Effect of PEGylation site and PEG molecular weight
[作者:Jung, S; Lee, SH; Mok, H; Chung, HJ; Park, TG,期刊:Journal of controlled release, 页码:306-313 , 文章类型: Article,,卷期:2010年144-3]
- Small interfering RNA (siRNA) was conjugated with poly(ethylene glycol) (PEG) at four different terminal ends (sense 3', sense 5', antisense 3', and antisense 5') via cleavable disulfide and noncleavable thioether linkag...
- A novel size-tunable nanocarrier system for targeted anticancer drug delivery
[作者:Li, YP; Xiao, K; Luo, JT; Lee, J; Pan, SR; Lam, KS,期刊:Journal of controlled release, 页码:314-323 , 文章类型: Article,,卷期:2010年144-3]
- We have developed a nanocarrier drug-delivery system based on micelles formed by a new class of well-defined linear PEGylated two-arm oligomer of cholic acids in aqueous solution. By varying the length of the linear PEG ...
- Benefit of anti-HER2-coated paclitaxel-loaded immuno-nanoparticles in the treatment of disseminated ovarian cancer: Therapeutic efficacy and biodistribution in mice
[作者:Cirstoiu-Hapca, A; Buchegger, F; Lange, N; Bossy, L; Gurny, R; Delie, F,期刊:Journal of controlled release, 页码:324-331 , 文章类型: Article,,卷期:2010年144-3]
- The benefit of polymeric immuno-nanoparticles (NPs-Tx-HER), consisting of paclitaxel (Tx)-loaded nanoparticles coated with anti-HER2 monoclonal antibodies (Herceptin (R), trastuzumab), in cancer treatment was assessed in...
- Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles
[作者:Zhigaltsev, IV; Winters, G; Srinivasulu, M; Crawford, J; Wong, M; Amankwa, L; Waterhouse, D; Masin, D; Webb, M; Harasym, N; Heller, L; Bally, MB; Ciufolini, MA; Cullis, PR; Maurer, N,期刊:Journal of controlled release, 页码:332-340 , 文章类型: Article,,卷期:2010年144-3]
- Hydrophobic uncharged drugs such as docetaxel are difficult to encapsulate and retain in liposomal nanoparticles (LNP). In this work we show that a weak base derivative of docetaxel can be actively loaded into LNP using ...
- Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells
[作者:Adrian, JE; Morselt, HWM; Suss, R; Barnert, S; Kok, JW; Asgeirsdottir, SA; Ruiters, MHJ; Molema, G; Kamps, JAAM,期刊:Journal of controlled release, 页码:341-349 , 文章类型: Article,,卷期:2010年144-3]
- In non-phagocytic cells such as endothelial cells, processing of liposomes and subsequent release of drug content is often inefficient due to the absence of professional processing machinery, which limits pharmacological...
- In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labeled liposomes
[作者:Castelli, DD; Dastru, W; Terreno, E; Cittadino, E; Mainini, F; Torres, E; Spadaro, M; Aime, S,期刊:Journal of controlled release, 页码:271-279 , 文章类型: Article,,卷期:2010年144-3]
- This work aims at developing a MRI method that allows to get more insight into the understanding of the in vivo fate of liposomes and their payload. The method relies on the temporal assessment of the contrast changes in...
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