- Cdc42 is an antihypertrophic molecular switch in the mouse heart
[作者:Maillet, M; Lynch, JM; Sanna, B; York, AJ; Zheng, Y; Molkentin, JD,期刊:Journal of clinical investigation, 页码:3079-3088 , 文章类型: Article,,卷期:2009年119-10]
- To improve contractile function, the myocardium undergoes hypertrophic growth without myocyte proliferation in response to both pathologic and physiologic stimulation. Various membrane-bound receptors and intermediate si...
- Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells
[作者:Brinkkoetter, PT; Olivier, P; Wu, JS; Henderson, S; Krofft, RD; Pippin, JW; Hockenbery, D; Roberts, JM; Shankland, SJ,期刊:Journal of clinical investigation, 页码:3089-3101 , 文章类型: Article,,卷期:2009年119-10]
- Cyclin I is an atypical cyclin because it is most abundant in postmitotic cells. We previously showed that cyclin I does not regulate proliferation, but rather controls survival of podocytes, terminally differentiated ep...
- The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism
[作者:Nechama, M; Uchida, T; Yosef-Levi, IM; Silver, J; Naveh-Many, T,期刊:Journal of clinical investigation, 页码:3102-3114 , 文章类型: Article,,卷期:2009年119-10]
- Secondary hyperparathyroidism is a major complication of chronic kidney disease (CKD). In experimental models of secondary hyperparathyroidism induced by hypocalcemia or CKD, parathyroid hormone (PTH) mRNA levels increas...
- A selective EP4 PGE(2) receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus
[作者:Li, JH; Chou, CL; Li, B; Gavrilova, O; Eisner, C; Schnermann, J; Anderson, SA; Deng, CX; Knepper, MA; Wess, J,期刊:Journal of clinical investigation, 页码:3115-3126 , 文章类型: Article,,卷期:2009年119-10]
- X-linked nephrogenic diabetes insipidus (XNDI) is a severe kidney disease caused by inactivating mutations in the V2 vasopressin receptor (V2R) gene that result in the loss of renal urine-concentrating ability. At presen...
- A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans
[作者:Mandinova, A; Kolev, V; Neel, V; Hu, B; Stonely, W; Lieb, J; Wu, XW; Colli, C; Han, R; Pazin, M; Ostano, P; Dummer, R; Brissette, JL; Dotto, GP,期刊:Journal of clinical investigation, 页码:3127-3137 , 文章类型: Article,,卷期:2009年119-10]
- Seborrheic keratoses (SKs) are common, benign epithelial tumors of the skin that do not, or very rarely, progress into malignancy, for reasons that are not understood. We investigated this by gene expression profiling of...
- The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice
[作者:Iwasawa, M; Miyazaki, T; Nagase, Y; Akiyama, T; Kadono, Y; Nakamura, M; Oshima, Y; Yasui, T; Matsumoto, T; Nakamura, T; Kato, S; Hennighausen, L; Nakamura, K; Tanaka, S,期刊:Journal of clinical investigation, 页码:3149-3159 , 文章类型: Article,,卷期:2009年119-10]
- The B cell lymphoma 2 (Bcl-2) family member Bcl-xL has a well-characterized antiapoptotic function in lymphoid cells. However, its functions in other cells - including osteoclasts, which are of hematopoietic origin and o...
- Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
[作者:Chang, SW; Biswas, K; Martin, BK; Stauffer, S; Sharan, SK,期刊:Journal of clinical investigation, 页码:3160-3171 , 文章类型: Article,,卷期:2009年119-10]
- To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identify BRCA1/2 mutation carrier...
- A simple biological imaging system for detecting viable human circulating tumor cells
[作者:Kojima, T; Hashimoto, Y; Watanabe, Y; Kagawa, S; Uno, F; Kuroda, S; Tazawa, H; Kyo, S; Mizuguchi, H; Urata, Y; Tanaka, N; Fujiwara, T,期刊:Journal of clinical investigation, 页码:3172-3181 , 文章类型: Article,,卷期:2009年119-10]
- The presence of circulating tumor cells (CTCs) in the peripheral blood is associated with short survival, making the detection of CTCs clinically useful as a prognostic factor of disease outcome and/or a surrogate marker...
- HIF2 alpha cooperates with RAS to promote lung tumorigenesis in mice (vol 119, pg 2160, 2009)
[作者:Kim, WY; Perera, S; Zhou, B; Carretero, J; Yeh, JJ; Heathcote, SA; Jackson, AL; Nikolinakos, P; Ospina, B; Naumov, GN; Brandstetter, KA; Weigman, VJ; Zaghlul, S; Hayes, DN; Padera, RF; Heymach, JV; Kung, AL; Sharpless, NE; Kaelin, WG; Wong, KK,期刊:Journal of clinical investigation, 页码:3182-3182 , 文章类型: Correction,,卷期:2009年119-10]
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