- The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
[作者:Song, LB; Li, J; Liao, WT; Feng, Y; Yu, CP; Hu, LJ; Kong, QL; Xu, LH; Zhang, X; Liu, WL; Li, MZ; Zhang, L; Kang, TB; Fu, LW; Huang, WL; Xia, YF; Tsao, SW; Li, MF; Band, V; Band, H; Shi, QH; Zeng, YX; Zeng, MS,期刊:Journal of clinical investigation, 页码:3626-3636 , 文章类型: Article,,卷期:2009年119-12]
- The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates with an invasive phenotype and poor prognosis in patients with ...
- An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
[作者:Tieu, BC; Lee, C; Sun, H; LeJeune, W; Recinos, A; Ju, XX; Spratt, H; Guo, DC; Milewicz, D; Tilton, RG; Brasier, AR,期刊:Journal of clinical investigation, 页码:3637-3651 , 文章类型: Article,,卷期:2009年119-12]
- Vascular inflammation contributes to cardiovascular diseases such as aortic aneurysm and dissection. However, the precise inflammatory pathways involved have not been clearly defined. We have shown here that subcutaneous...
- Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks
[作者:Dunham-Ems, SM; Caimano, MJ; Pal, U; Wolgemuth, CW; Eggers, CH; Balic, A; Radolf, JD,期刊:Journal of clinical investigation, 页码:3652-3665 , 文章类型: Article,,卷期:2009年119-12]
- Lyme disease is caused by transmission of the. spirochete Borrelia burgdorferi from ticks to humans. Although much is known about B. burgdorferi replication, the routes and mechanisms by which it disseminates within the ...
- A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
[作者:Li, H; Xie, H; Liu, W; Hu, R; Huang, B; Tan, YF; Liao, EY; Xu, K; Sheng, ZF; Zhou, HD; Wu, XP; Luo, XH,期刊:Journal of clinical investigation, 页码:3666-3677 , 文章类型: Article,,卷期:2009年119-12]
- MicroRNAs (miRNAs) interfere with translation of specific target mRNAs and are thought to thereby regulate many cellular processes. Recent studies have suggested that miRNAs might play a role in osteoblast differentiatio...
- Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis
[作者:Yang, JX; Jiang, ZL; Fitzgerald, DC; Ma, CG; Yu, S; Li, HM; Zhao, Z; Li, YH; Ciric, B; Curtis, M; Rostami, A; Zhang, GX,期刊:Journal of clinical investigation, 页码:3678-3691 , 文章类型: Article,,卷期:2009年119-12]
- Adult neural stem cells (aNSCs) derived from the subventricular zone of the brain show therapeutic effects in EAE, an animal model of the chronic inflammatory neurodegenerative disease MS; however, the beneficial. effect...
- NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease
[作者:Varvel, NH; Bhaskar, K; Kounnas, MZ; Wagner, SL; Yang, Y; Lamb, BT; Herrup, K,期刊:Journal of clinical investigation, 页码:3692-3702 , 文章类型: Article,,卷期:2009年119-12]
- Ectopic cell cycle events (CCEs) mark vulnerable neuronal populations in human Alzheimer disease (AD) and are observed early in disease progression. In transgenic mouse models of AD, CCEs are found before the onset of be...
- Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice
[作者:Heydemann, A; Ceco, E; Lim, JE; Hadhazy, M; Ryder, P; Moran, JL; Beier, DR; Palmer, AA; McNally, EM,期刊:Journal of clinical investigation, 页码:3703-3712 , 文章类型: Article,,卷期:2009年119-12]
- Most single-gene diseases, including muscular dystrophy, display a nonuniform phenotype. Phenotypic variability arises, in part, due to the presence of genetic modifiers that enhance or suppress the disease process. We e...
- Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
[作者:Atabai, K; Jame, S; Azhar, N; Kuo, A; Lam, M; McKleroy, W; DeHart, G; Rahman, S; Xia, DD; Melton, AC; Wolters, P; Emson, CL; Turner, SM; Werb, Z; Sheppard, D,期刊:Journal of clinical investigation, 页码:3713-3722 , 文章类型: Article,,卷期:2009年119-12]
- Milk fat globule epidermal growth factor 8 (Mfge8) is a soluble glycoprotein known to regulate inflammation and immunity by mediating apoptotic cell clearance. Since fibrosis can occur as a result of exaggerated apoptosi...
- Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
[作者:Bedoret, D; Wallemacq, H; Marichal, T; Desmet, C; Calvo, FQ; Henry, E; Closset, R; Dewals, B; Thielen, C; Gustin, P; de Leval, L; Van Rooijen, N; Le Moine, A; Vanderplasschen, A; Cataldo, D; Drion, PV; Moser, M; Lekeux, P; Bureau, F,期刊:Journal of clinical investigation, 页码:3723-3738 , 文章类型: Article,,卷期:2009年119-12]
- The respiratory tract is continuously exposed to both innocuous airborne antigens and immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, airborne LPS can induce a lung DC-driven Th2 cell...
- Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression
[作者:Lai, JJ; Lai, KP; Chuang, KH; Chang, P; Yu, IC; Lin, WJ; Chang, C,期刊:Journal of clinical investigation, 页码:3739-3751 , 文章类型: Article,,卷期:2009年119-12]
- Cutaneous wounds heal more slowly in elderly males than in elderly females, suggesting a role for sex hormones in the healing process. Indeed, androgen/androgen receptor (AR) signaling has been shown to inhibit cutaneous...
- The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice
[作者:Volle, DH; Decourteix, M; Garo, E; McNeilly, J; Fenichel, P; Auwerx, J; McNeilly, AS; Schoonjans, K; Benahmed, M,期刊:Journal of clinical investigation, 页码:3752-3764 , 文章类型: Article,,卷期:2009年119-12]
- Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (...
- Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells
[作者:Cote, M; Menager, MM; Burgess, A; Mahlaoui, N; Picard, C; Schaffner, C; Al-Manjomi, F; Al-Harbi, M; Alangari, A; Le Deist, F; Gennery, AR; Prince, N; Cariou, A; Nitschke, P; Blank, U; El-Ghazali, G; Menasche, G; Latour, S; Fischer, A; de Saint Basile, G,期刊:Journal of clinical investigation, 页码:3765-3773 , 文章类型: Article,,卷期:2009年119-12]
- Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous autosomal recessive immune disorder characterized by the occurrence of uncontrolled activation of lymphocytes and macrophages infiltrating ...
- PKC theta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice
[作者:Valenzuela, JO; Iclozan, C; Hossain, MS; Prlic, M; Hopewell, E; Bronk, CC; Wang, JM; Celis, E; Engelman, RW; Blazar, BR; Bevan, MJ; Waller, EK; Yu, XZ; Beg, AA,期刊:Journal of clinical investigation, 页码:3774-3786 , 文章类型: Article,,卷期:2009年119-12]
- When used as therapy for hematopoietic malignancies, allogeneic BM transplantation (BMT) relies on the graft-versus-leukemia (GVL) effect to eradicate residual tumor cells through immunologic mechanisms. However, graft-v...
- alpha 1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice
[作者:Nakayama, H; Bodi, I; Correll, RN; Chen, XW; Lorenz, J; Houser, SR; Robbins, J; Schwartz, A; Molkentin, JD,期刊:Journal of clinical investigation, 页码:3787-3796 , 文章类型: Article,,卷期:2009年119-12]
- In noncontractile cells, increases in intracellular Ca2+ concentration serve as a second messenger to signal proliferation, differentiation, metabolism, motility, and cell death. Many of these Ca2+-dependent regulatory p...
- PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1
[作者:Wang, GS; Kuyumcu-Martinez, MN; Sarma, S; Mathur, N; Wehrens, XHT; Cooper, TA,期刊:Journal of clinical investigation, 页码:3797-3806 , 文章类型: Article,,卷期:2009年119-12]
- Cardiac complications are a common cause of death in individuals with the inherited multisystemic disease myotonic dystrophy type 1 (DM1). A characteristic molecular feature of DM1 is misregulated alternative splicing du...
- Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion
[作者:Qi, D; Hu, XY; Wu, XH; Merk, M; Leng, L; Bucala, R; Young, LH,期刊:Journal of clinical investigation, 页码:3807-3816 , 文章类型: Article,,卷期:2009年119-12]
- Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that also modulates physiologic cell signaling pathways. MIF is expressed in cardiomyocytes and limits cardiac injury by enhancing AMPK activity ...
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