- Laminin deposition in the extracellular matrix: a complex picture emerges
[作者:Hamill, KJ; Kligys, K; Hopkinson, SB; Jones, JCR,期刊:Journal of cell science, 页码:4409-4417 , 文章类型: Editorial Material,,卷期:2009年122-24]
- Laminins are structural components of basement membranes. In addition, they are key extracellular-matrix regulators of cell adhesion, migration, differentiation and proliferation. This Commentary focuses on a relatively ...
- A dual role for EDEM1 in the processing of rod opsin
[作者:Kosmaoglou, M; Kanuga, N; Aguila, M; Garriga, P; Cheetham, ME,期刊:Journal of cell science, 页码:4465-4472 , 文章类型: Article,,卷期:2009年122-24]
- Mutations in rod opsin, the archetypal G-protein-coupled receptor, cause retinitis pigmentosa. The majority of mutations, e.g. P23H, cause protein misfolding, resulting in ER retention, induction of the unfolded protein ...
- Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis
[作者:Janssen, K; Horn, S; Niemann, MT; Daniel, PT; Schulze-Osthoff, K; Fischer, U,期刊:Journal of cell science, 页码:4481-4491 , 文章类型: Article,,卷期:2009年122-24]
- Tumor cells deficient in the proapoptotic proteins Bak and Bax are resistant to chemotherapeutic drugs. Here, we demonstrate that murine embryonic fibroblasts deficient for both Bak and Bax are, however, efficiently kill...
- The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans
[作者:Bhattacharya, R; Townley, RA; Berry, KL; Bulow, HE,期刊:Journal of cell science, 页码:4492-4504 , 文章类型: Article,,卷期:2009年122-24]
- Sulfations of sugars, such as heparan sulfates (HS), or tyrosines require the universal sulfate donor 3'-phospho-adenosine-5'-phosphosulfate (PAPS) to be transported from the cytosol into the Golgi. Metazoan genomes enco...
- Toll-dependent antimicrobial responses in Drosophila larval fat body require Spatzle secreted by haemocytes
[作者:Shia, AKH; Glittenberg, M; Thompson, G; Weber, AN; Reichhart, JM; Ligoxygakis, P,期刊:Journal of cell science, 页码:4505-4515 , 文章类型: Article,,卷期:2009年122-24]
- In Drosophila, the humoral response characterised by the synthesis of antimicrobial peptides (AMPs) in the fat body (the equivalent of the mammalian liver) and the cellular response mediated by haemocytes (blood cells) e...
- Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis
[作者:Echave, P; Machado-da-Silva, G; Arkell, RS; Duchen, MR; Jacobson, J; Mitter, R; Lloyd, AC,期刊:Journal of cell science, 页码:4516-4525 , 文章类型: Article,,卷期:2009年122-24]
- Cells generate new organelles when stimulated by extracellular factors to grow and divide; however, little is known about how growth and mitogenic signalling pathways regulate organelle biogenesis. Using mitochondria as ...
- TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila
[作者:Robinett, CC; Giansanti, MG; Gatti, M; Fuller, MT,期刊:Journal of cell science, 页码:4526-4534 , 文章类型: Article,,卷期:2009年122-24]
- Although membrane addition is crucial for cytokinesis in many animal cell types, the specific mechanisms supporting cleavage furrow ingression are not yet understood. Mutations in the gene brunelleschi (bru), which encod...
- The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration
[作者:Bristow, JM; Sellers, MH; Majumdar, D; Anderson, B; Hu, L; Webb, DJ,期刊:Journal of cell science, 页码:4535-4546 , 文章类型: Article,,卷期:2009年122-24]
- Asef2 is a recently identified Rho-family guanine nucleotide exchange factor (GEF) that has been implicated in the modulation of actin, but its function in cell migration and adhesion dynamics is not well understood. In ...
- CaMKII alpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis
[作者:Ackermann, F; Zitranski, N; Borth, H; Buech, T; Gudermann, T; Boekhoff, I,期刊:Journal of cell science, 页码:4547-4557 , 文章类型: Review,,卷期:2009年122-24]
- The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules. Since the acrosome reaction resembles Ca2+-regulat...
- MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices
[作者:Fisher, KE; Sacharidou, A; Stratman, AN; Mayo, AM; Fisher, SB; Mahan, RD; Davis, MJ; Davis, GE,期刊:Journal of cell science, 页码:4558-4569 , 文章类型: Article,,卷期:2009年122-24]
- Complex signaling events control tumor invasion in three-dimensional (3D) extracellular matrices. Recent evidence suggests that cells utilize both matrix metalloproteinase (MMP)-dependent and MMP-independent means to tra...
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