- Impaired S-Phase Arrest in Acute Myeloid Leukemia Cells with a FLT3 Internal Tandem Duplication Treated with Clofarabine
[作者：Seedhouse, C; Grundy, M; Shang, SL; Ronan, J; Pimblett, H; Russell, N; Pallis, M,期刊：Clinical Cancer Research, 页码：7291-7298 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Acute myeloid leukemia cells with an internal tandem duplication mutation of FLT3 (FLT3-ITD) have effective DNA repair mechanisms on exposure to drugs. Despite this, the phenotype is not associated with primary ...
- Targeted Drug and Gene Delivery Systems for Lung Cancer Therapy
[作者：Sundaram, S; Trivedi, R; Durairaj, C; Ramesh, R; Ambati, BK; Kompella, UB,期刊：Clinical Cancer Research, 页码：7299-7308 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: To evaluate the efficacy of a novel docetaxel derivative of deslorelin, a luteinizing hormone-releasing hormone (LHRH) agonist, and its combination in vivo with RGD peptide conjugated nanoparticles encapsulating...
- A Four-Gene Signature from NCI-60 Cell Line for Survival Prediction in Non-Small Cell Lung Cancer
[作者：Hsu, YC; Yuan, S; Chen, HY; Yu, SL; Liu, CH; Hsu, PY; Wu, G; Lin, CH; Chang, GC; Li, KC; Yang, PC,期刊：Clinical Cancer Research, 页码：7309-7315 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Metastasis is the main cause of mortality in non-small cell lung cancer (NSCLC) patients. Genes that can discriminate the invasion ability of cancer cells may become useful candidates for clinical outcome predic...
- Pro-Prostate-Specific Antigen Measurements in Serum and Tissue Are Associated with Treatment Necessity among Men Enrolled in Expectant Management for Prostate Cancer
[作者：Makarov, DV; Isharwal, S; Sokoll, LJ; Landis, P; Marlow, C; Epstein, JI; Partin, AW; Carter, HB; Veltri, RW,期刊：Clinical Cancer Research, 页码：7316-7321 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: We assessed the association of quantitative clinical and pathologic information, including serum and tissue pro-prostate-specific antigen (proPSA) measurements, with outcomes among men with prostate cancer in an...
- KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803
[作者：Ogino, S; Meyerhardt, JA; Irahara, N; Niedzwiecki, D; Hollis, D; Saltz, LB; Mayer, RJ; Schaefer, P; Whittom, R; Hantel, A; Benson, A; Goldberg, RM; Bertagnolli, MM; Fuchs, CS,期刊：Clinical Cancer Research, 页码：7322-7329 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Alterations in the RAS and RAF pathway relate to epigenetic and epigenomic aberrations, and are important in colorectal carcinogenesis. KRAS mutation in metastatic colorectal cancer predicts resistance to anti-e...
- KIR and HLA Genotypes Are Associated with Disease Progression and Survival following Autologous Hematopoietic Stem Cell Transplantation for High-Risk Neuroblastoma
[作者：Venstrom, JM; Zhen, JT; Noor, N; Danis, KE; Yeh, AW; Cheung, IY; Dupont, B; O'Reilly, RJ; Cheung, NKV; Hsu, KC,期刊：Clinical Cancer Research, 页码：7330-7334 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: NK cells exhibit cytotoxicity against neuroblastoma. Gene polymorphisms governing NK cell function, therefore, may influence prognosis. Two highly polymorphic genetic loci instrumental in determining NK cell res...
- DNA Replication Licensing Factors and Aneuploidy Are Linked to Tumor Cell Cycle State and Clinical Outcome in Penile Carcinoma
[作者：Kayes, OJ; Loddo, M; Patel, N; Patel, P; Minhas, S; Ambler, G; Freeman, A; Wollenschlaeger, A; Ralph, DJ; Stoeber, K; Williams, GH,期刊：Clinical Cancer Research, 页码：7335-7344 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: The DNA replication licensing machinery is integral to the control of proliferation, differentiation, and maintenance of genomic stability in human cells. We have analyzed replication licensing factors (RLF), to...
- L1 Cell Adhesion Molecule Is a Novel Independent Poor Prognostic Factor of Extrahepatic Cholangiocarcinoma
[作者：Li, S; Jo, YS; Lee, JH; Min, JK; Lee, ES; Park, T; Kim, JM; Hong, HJ,期刊：Clinical Cancer Research, 页码：7345-7351 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Cholangiocarcinomas (CC) are associated with poor survival, but diagnostic markers and therapeutic targets have not yet been elucidated. We previously found aberrant expression of L1 cell adhesion molecule in in...
- Involvement of Mitochondrial DNA Sequence Variations and Respiratory Activity in Late Complications following Radiotherapy
[作者：Alsbeih, GA; Al-Harbi, NM; El-Sebaie, MM; Al-Rajhi, NM; Al-Hadyan, KS; Abu-Amero, KK,期刊：Clinical Cancer Research, 页码：7352-7360 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Mitochondria and ionizing radiation overlap in a number of features; for instance, both generate harmful reactive oxygen species, and that radiation can induce cell death through the intermediary of mitochondria...
- Randomized Trial and Pharmacokinetic Study of Pegfilgrastim versus Filgrastim after Dose-Intensive Chemotherapy in Young Adults and Children with Sarcomas
[作者：Fox, E; Widemann, BC; Hawkins, DS; Jayaprakash, N; Dagher, R; Aikin, AA; Bernstein, D; Long, L; Mackall, C; Helman, L; Steinberg, SM; Balis, FM,期刊：Clinical Cancer Research, 页码：7361-7367 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: To compare the effectiveness, tolerance, and pharmacokinetics of a single dose of pegfilgrastim to daily filgrastim in children and young adults with sarcomas treated with dose-intensive combination chemotherapy...
- The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of CH4987655 in Healthy Volunteers: Target Suppression Using a Biomarker
[作者：Lee, L; Niu, HF; Rueger, R; Igawa, Y; Deutsch, J; Ishii, N; Mu, S; Sakamoto, Y; Busse-Reid, R; Gimmi, C; Goelzer, P; De Schepper, S; Yoshimura, Y; Barrett, J; Ishikawa, Y; Weissgerber, G; Peck, R,期刊：Clinical Cancer Research, 页码：7368-7374 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor. It potently inhibits mitogen-activated protein kinase signaling pathway activation and tumor cell growth, with an in v...
- Phase I Clinical Trial of an Adenovirus/Prostate-Specific Antigen Vaccine for Prostate Cancer: Safety and Immunologic Results
[作者：Lubaroff, DM; Konety, BR; Link, B; Gerstbrein, J; Madsen, T; Shannon, M; Howard, J; Paisley, J; Boeglin, D; Ratliff, TL; Williams, RD,期刊：Clinical Cancer Research, 页码：7375-7380 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: We performed a phase I clinical trial of adenovirus/prostate-specific antigen (PSA) vaccine in men with measurable metastatic hormone-refractory disease.Experimental Design: Men with measurable metastatic diseas...
- HIF-1 alpha and HIF-2 alpha Are Differentially Regulated In vivo in Neuroblastoma: High HIF-1 alpha Correlates Negatively to Advanced Clinical Stage and Tumor Vascularization
[作者：Noguera, R; Fredlund, E; Piqueras, M; Pietras, A; Beckman, S; Navarro, S; Pahlman, S,期刊：Clinical Cancer Research, 页码：7130-7136 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Hypoxia is considered to be a major driving force behind tumor angiogenesis. The stabilization and activation at hypoxia of the hypoxia-inclucible factors HIF-1 alpha and HIF-2 alpha and the concomitant inductio...
- Rapid Identification of Clinical Relevant Minor Histocompatibility Antigens via Genome-Wide Zygosity-Genotype Correlation Analysis
[作者：Spaapen, RM; de Kort, RAL; van den Oudenalder, K; van Elk, M; Bloem, AC; Lokhorst, HM; Mutis, T,期刊：Clinical Cancer Research, 页码：7137-7143 , 文章类型： Article，,卷期：2009年15-23]
- Purpose: Identification of minor histocompatibility antigens (mHag) with classic methods often requires sophisticated technologies, determination, and patience. We here describe and validate a nonlaborious and convenient...
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