- Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells
[作者:Zhang, YV; Cheong, J; Ciapurin, N; McDermitt, DJ; Tumbar, T,期刊:Cell Stem Cell, 页码:267-278 , 文章类型: Article,,卷期:2009年5-3]
- In homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell committed to differentiate. ...
- mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
[作者:Castilho, RM; Squarize, CH; Chodosh, LA; Williams, BO; Gutkind, JS,期刊:Cell Stem Cell, 页码:279-289 , 文章类型: Article,,卷期:2009年5-3]
- Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. Although Wnt regulates normal epithelial stem cell renewal, aberrant Wnt...
- Autocrine and Paracrine Angiopoietin 1/Tie-2 Signaling Promotes Muscle Satellite Cell Self-Renewal
[作者:Abou-Khalil, R; Le Grand, F; Pallafacchina, G; Valable, S; Authier, FJ; Rudnicki, MA; Gherardi, RK; Germain, S; Chretien, F; Sotiropoulos, A; Lafuste, P; Montarras, D; Chazaud, B,期刊:Cell Stem Cell, 页码:298-309 , 文章类型: Article,,卷期:2009年5-3]
- Mechanisms governing muscle satellite cell withdrawal from cell cycle to enter into quiescence remain poorly understood. We studied the role of angiopoietin 1 (Ang1) and its receptor Tie-2 in the regulation of myogenic p...
- Neuroprotection of Host Cells by Human Central Nervous System Stem Cells in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis
[作者:Tamaki, SJ; Jacobs, Y; Dohse, M; Capela, A; Cooper, JD; Reitsma, M; He, DP; Tushinski, R; Belichenko, PV; Salehi, A; Mobley, W; Gage, FH; Huhn, S; Tsukamoto, AS; Weissman, IL; Uchida, N,期刊:Cell Stem Cell, 页码:310-319 , 文章类型: Article,,卷期:2009年5-3]
- Infantile neuronal ceroid lipofuscinosis (INCL) is a fatal neurodegenerative disease caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). Ppt1 knockout mice display hallmarks of INCL an...
- Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors
[作者:Lange, C; Huttner, WB; Calegari, F,期刊:Cell Stem Cell, 页码:320-331 , 文章类型: Article,,卷期:2009年5-3]
- During mouse embryonic development, neural progenitors lengthen the G1 phase of the cell cycle and this has been suggested to be a cause, rather than a consequence, of neurogenesis. To investigate whether G1 lengthening ...
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