- An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
[作者:van den Berg, DLC; Snoek, T; Mullin, NP; Yates, A; Bezstarosti, K; Demmers, J; Chambers, I; Poot, RA,期刊:Cell Stem Cell, 页码:369-381 , 文章类型: Article,,卷期:2010年6-4]
- Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum o...
- An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease
[作者:Pardo, M; Lang, B; Yu, L; Prosser, H; Bradley, A; Babu, MM; Choudhary, J,期刊:Cell Stem Cell, 页码:382-395 , 文章类型: Article,,卷期:2010年6-4]
- The transcription factor Oct4 is key in embryonic stem cell identity and reprogramming. Insight into its partners should illuminate how the pluripotent state is established and regulated. Here, we identify a considerably...
- Cell Competition: Pirates on the Tangled Bank
[作者:Green, DR,期刊:Cell Stem Cell, 页码:287-288 , 文章类型: Editorial Material,,卷期:2010年6-4]
- Competition by stem cells for occupation of a limited niche is a well-described phenomenon. Two recent studies highlight competition between hematopoietic stem cells based on p53. These findings have implications for bot...
- Visualizing Blood Cell Emergence from Aortic Endothelium
[作者:Swiers, G; Speck, NA; de Bruijn, MFTR,期刊:Cell Stem Cell, 页码:289-290 , 文章类型: Editorial Material,,卷期:2010年6-4]
- Three recent Nature papers use time-lapse confocal imaging to visualize the birth of blood cells from the aortic endothelium. Two studies (Bertrand et al., 2010; Kissa and Herbomel, 2010) utilize the zebrafish embryo, wh...
- Hooking Up with Oct4
[作者:Lemischka, IR,期刊:Cell Stem Cell, 页码:291-292 , 文章类型: Editorial Material,,卷期:2010年6-4]
- The transcription factor Oct4 plays a central role in controlling the undifferentiated state of embryonic and induced pluripotent stem cells. Two complementary papers in this issue of Cell Stem Cell describe the extended...
- Cycling toward Elimination of Leukemic Stem Cells
[作者:Goff, D; Jamieson, C,期刊:Cell Stem Cell, 页码:296-297 , 文章类型: Editorial Material,,卷期:2010年6-4]
- In two recent articles in Science Translational Medicine and Nature Biotechnology, Saito et al. (2010) identify a molecular signature of acute myeloid leukemia (AML) stem cells and demonstrate that quiescent AML stem cel...
- MicroRNA-9 Coordinates Proliferation and Migration of Human Embryonic Stem Cell-Derived Neural Progenitors
[作者:Delaloy, C; Liu, L; Lee, JA; Su, H; Shen, FX; Yang, GY; Young, WL; Ivey, KN; Gao, FB,期刊:Cell Stem Cell, 页码:323-335 , 文章类型: Article,,卷期:2010年6-4]
- Human pluripotent stem cells offer promise for use in cell-based therapies for brain injury and diseases. However, their cellular behavior is poorly understood. Here we show that the expression of the brain-specific micr...
- HOW Is Required for Stem Cell Maintenance in the Drosophila Testis and for the Onset of Transit-Amplifying Divisions
[作者:Monk, AC; Siddall, NA; Volk, T; Fraser, B; Quinn, LM; McLaughlin, EA; Hime, GR,期刊:Cell Stem Cell, 页码:348-360 , 文章类型: Article,,卷期:2010年6-4]
- The mechanisms by which germline stem cells (GSCs) in the Drosophila testis undergo asymmetric division to regenerate a stem cell as well as a daughter (gonialblast) that will only undergo a further four mitotic division...
- Distinguishing Mast Cell and Granulocyte Differentiation at the Single-Cell Level
[作者:Franco, CB; Chen, CC; Drukker, M; Weissman, IL; Galli, SJ,期刊:Cell Stem Cell, 页码:361-368 , 文章类型: Article,,卷期:2010年6-4]
- The lineage restriction of prospectively isolated hematopoietic progenitors has been traditionally assessed by bulk in vitro culture and transplantation of large number of cells in vivo. These methods, however, cannot di...
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