- Gonadotropin-Regulated Lymphangiogenesis in Ovarian Cancer Is Mediated by LEDGF-Induced Expression of VEGF-C
[作者:Sapoznik, S; Cohen, B; Tzuman, Y; Meir, G; Ben-Dor, S; Harmelin, A; Neeman, M,期刊:Cancer research, 页码:9306-9314 , 文章类型: Article,,卷期:2009年69-24]
- The risk and severity of ovarian carcinoma, the leading cause of gynecologic malignancy death, are significantly elevated in postmenopausal women. Ovarian failure at menopause, associated with a reduction in estrogen sec...
- Testing the Circadian Gene Hypothesis in Prostate Cancer: A Population-Based Case-Control Study
[作者:Zhu, Y; Stevens, RG; Hoffman, AE; FitzGerald, LM; Kwon, EM; Ostrander, EA; Davis, S; Zheng, TZ; Stanford, JL,期刊:Cancer research, 页码:9315-9322 , 文章类型: Article,,卷期:2009年69-24]
- Circadian genes are responsible for maintaining the ancient adaptation of a 24-hour circadian rhythm and influence a variety of cancer-related biological pathways, including the regulation of sex hormone levels. However,...
- Circulating Carotenoids, Mammographic Density, and Subsequent Risk of Breast Cancer
[作者:Tamimi, RM; Colditz, GA; Hankinson, SE,期刊:Cancer research, 页码:9323-9329 , 文章类型: Article,,卷期:2009年69-24]
- Mammographic density is one of the strongest predictors of breast cancer risk. Recently, it has been suggested that reactive oxygen species may influence breast cancer risk through its influence on mammographic density. ...
- Strongly Enhanced Antitumor Activity of Trastuzumab and Pertuzumab Combination Treatment on HER2-Positive Human Xenograft Tumor Models
[作者:Scheuer, W; Friess, T; Burtscher, H; Bossenmaier, B; Endl, J; Hasmann, M,期刊:Cancer research, 页码:9330-9336 , 文章类型: Article,,卷期:2009年69-24]
- The human epidermal growth factor receptor (HER) family plays an important role in cell survival and proliferation, and is implicated in oncogenesis. Overexpression of HER2 is associated with aggressive disease and poor ...
- Imatinib Mesylate Induces Cisplatin Hypersensitivity in Bcr-Abl(+) Cells by Differential Modulation of p53 Transcriptional and Proapoptotic Activity
[作者:Skorta, I; Oren, M; Markwardt, C; Gutekunst, M; Aulitzky, WE; van der Kuip, H,期刊:Cancer research, 页码:9337-9345 , 文章类型: Article,,卷期:2009年69-24]
- Imatinib is highly effective in inducing remission in chronic myelogenous leukemia (CML). However, complete eradication of the malignant clone by imatinib is rare. We investigated the efficacy of combining imatinib with ...
- Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation
[作者:Colie, S; Van Veldhoven, PP; Kedjouar, B; Bedia, C; Albinet, V; Sorli, SC; Garcia, V; Djavaheri-Mergny, M; Bauvy, C; Codogno, P; Levade, T; Andrieu-Abadie, N,期刊:Cancer research, 页码:9346-9353 , 文章类型: Article,,卷期:2009年69-24]
- Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation of SIP is cat...
- MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice
[作者:Kanda, T; Raychoudhuri, A; Steele, R; Sagartz, JE; West, C; Ray, RB,期刊:Cancer research, 页码:9354-9359 , 文章类型: Article,,卷期:2009年69-24]
- Breast cancer is the leading cause of cancer death among women. We have shown previously an antiproliferative effect of MBP-1 on several human cancer cells. In this study, we have examined the potential of MBP-1 as a gen...
- High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors
[作者:Beyrouthy, MJ; Garner, KM; Hever, MP; Freemantle, SJ; Eastman, A; Dmitrovsky, E; Spinella, MJ,期刊:Cancer research, 页码:9360-9366 , 文章类型: Article,,卷期:2009年69-24]
- Testicular germ cell tumors (TGCT) are the most common solid tumors of 15- to 35-year-old men. TGCT patients are frequently cured with cytotoxic cisplatin-based therapy. However, TGCT patients refractory to cisplatin-bas...
- Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma.
[作者:Yarde, DN; Oliveira, V; Mathews, L; Wang, XY; Villagra, A; Boulware, D; Shain, KH; Hazlehurst, LA; Alsina, M; Chen, DT; Beg, AA; Dalton, WS,期刊:Cancer research, 页码:9367-9375 , 文章类型: Article,,卷期:2009年69-24]
- The Fanconi anemia/BRCA (FA/BRCA) DNA damage repair pathway plays a pivotal role in the cellular response to replicative stress induced by DNA alkylating agents and greatly influences drug response in cancer treatment. W...
- In vivo Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer
[作者:Ugel, S; Zoso, A; De Santo, C; Li, Y; Marigo, I; Zanovello, P; Scarselli, E; Cipriani, B; Oelke, M; Schneck, JP; Bronte, V,期刊:Cancer research, 页码:9376-9384 , 文章类型: Article,,卷期:2009年69-24]
- The development of effective antitumor immune responses is normally constrained by low-avidity, tumor-specific CTLs that are unable to eradicate the tumor. Strategies to rescue antitumor activity of low-avidity in melano...
- Reprogramming T Lymphocytes for Melanoma Adoptive Immunotherapy by T-Cell Receptor Gene Transfer with Lentiviral Vectors
[作者:Bobisse, S; Rondina, M; Merlo, A; Tisato, V; Mandruzzato, S; Amendola, M; Naldini, L; Willemsen, RA; Debets, R; Zanovello, P; Rosato, A,期刊:Cancer research, 页码:9385-9394 , 文章类型: Article,,卷期:2009年69-24]
- T-cell receptor (TCR) gene transfer for cancer immunotherapy is limited by the availability of large numbers of tumor-specific T cells. TCR alpha and beta chains were isolated from a highly lytic HLA-A2-restricted cytoto...
- Folate Receptor beta Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages
[作者:Puig-Kroger, A; Sierra-Filardi, E; Dominguez-Soto, A; Samaniego, R; Corcuera, MT; Gomez-Aguado, F; Ratnam, M; Sanchez-Mateos, P; Corbi, AL,期刊:Cancer research, 页码:9395-9403 , 文章类型: Article,,卷期:2009年69-24]
- Macrophage activation comprises a continuum of functional states critically determined by cytokine microenvironment. Activated macrophages have been functionally grouped according to their response to pro-Th1/proinflamma...
- Heat Shock Factor 1-Mediated Aneuploidy Requires a Defective Function of p53
[作者:Kim, EH; Lee, YJ; Bae, S; Lee, JS; Kim, J; Lee, YS,期刊:Cancer research, 页码:9404-9412 , 文章类型: Article,,卷期:2009年69-24]
- Because heat shock factor 1 (HSF1) phosphorylation by Plk1 has been previously reported to he involved in mitotic regulation and p53 function may be involved in this mitotic regulation, we have further examined HSF1 func...
- Deficiency of pRb Family Proteins and p53 in Invasive Urothelial Tumorigenesis
[作者:He, F; Mo, L; Zheng, XY; Hu, CK; Lepor, H; Lee, EYHP; Sun, TT; Wu, XR,期刊:Cancer research, 页码:9413-9421 , 文章类型: Article,,卷期:2009年69-24]
- Defects in pRb tumor suppressor pathway occur in similar to 50% of the deadly muscle-invasive urothelial carcinomas in humans and urothelial carcinoma is the most prevalent epithelial cancer in long-term survivors of her...
- Global Changes in Processing of mRNA 3 ' Untranslated Regions Characterize Clinically Distinct Cancer Subtypes
[作者:Singh, P; Alley, TL; Wright, SM; Kamdar, S; Schott, W; Wilpan, RY; Mills, KD; Graber, JH,期刊:Cancer research, 页码:9422-9430 , 文章类型: Article,,卷期:2009年69-24]
- Molecular cancer diagnostics are an important clinical advance in cancer management, but new methods are still needed. In this context, gene expression signatures obtained by microarray represent a useful molecular diagn...
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