- Premenopausal Mammographic Density in Relation to Cyclic Variations in Endogenous Sex Hormone Levels, Prolactin, and Insulin-like Growth Factors
[作者:Walker, K; Fletcher, O; Johnson, N; Coupland, B; McCormack, VA; Folkerd, E; Gibson, L; Hillier, SG; Holly, JM; Moss, S; Dowsett, M; Peto, J; Silva, ID,期刊:Cancer research, 页码:6490-6499 , 文章类型: Article,,卷期:2009年69-16]
- Mammographic density is strongly associated with breast cancer risk, and endogenous hormones, which are risk factors for breast cancer, may be involved in the mechanism. This cross-sectional study of 494 premenopausal wo...
- Follicle-Stimulating Hormone Peptide Can Facilitate Paclitaxel Nanoparticles to Target Ovarian Carcinoma In vivo
[作者:Zhang, XY; Chen, J; Zheng, YF; Gao, XL; Kang, Y; Liu, JC; Cheng, MJ; Sun, H; Xu, CJ,期刊:Cancer research, 页码:6506-6514 , 文章类型: Article,,卷期:2009年69-16]
- Chemotherapy is an important treatment for ovarian cancer. However, conventional chemotherapy has inevitable drawbacks due to side effects from nonspecific biodistribution of the chemotherapeutic drugs. To solve such pro...
- Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression Are the Result of Loss of Breast Tissue Polarity
[作者:Chen, A; Cuevas, I; Kenny, PA; Miyake, H; Mace, K; Ghajar, C; Boudreau, A; Bissell, M; Boudreau, N,期刊:Cancer research, 页码:6721-6729 , 文章类型: Article,,卷期:2009年69-16]
- Recruiting a new blood supply is a rate-limiting step in tumor progression. In a three-dimensional model of breast carcinogenesis, disorganized, proliferative transformed breast epithelial cells express significantly hig...
- Overexpression of Protease-Activated Receptor-1 Contributes to Melanoma Metastasis via Regulation of Connexin 43
[作者:Villares, GJ; Dobroff, AS; Wang, H; Zigler, M; Melnikova, VO; Huang, L; Bar-Eli, M,期刊:Cancer research, 页码:6730-6737 , 文章类型: Article,,卷期:2009年69-16]
- Protease-activated receptor-1 (PAR-1) is a key player in melanoma metastasis with higher expression seen in metastatic melanoma cell lines and tissue specimens. cDNA microarray and Western blot analyses reveal that the g...
- Sorafenib Inhibits Non-Small Cell Lung Cancer Cell Growth by Targeting B-RAF in KRAS Wild-Type Cells and C-RAF in KRAS Mutant Cells
[作者:Takezawa, K; Okamoto, I; Yonesaka, K; Hatashita, E; Yamada, Y; Fukuoka, M; Nakagawa, K,期刊:Cancer research, 页码:6515-6521 , 文章类型: Article,,卷期:2009年69-16]
- Sorafenib is a multikinase inhibitor whose targets include B-RAF and C-RAF, both of which function in the extracellular signal-regulated kinase (ERK) signaling pathway but which also have distinct downstream targets. The...
- Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
[作者:Attar, RM; Jure-Kunkel, M; Balog, A; Cvijic, ME; Dell-John, J; Rizzo, CA; Schweizer, L; Spires, TE; Platero, JS; Obermeier, M; Shan, WF; Salvati, ME; Foster, WR; Dinchuk, J; Chen, SJ; Vite, G; Kramer, R; Gottardis, MM,期刊:Cancer research, 页码:6522-6530 , 文章类型: Article,,卷期:2009年69-16]
- Despite an excellent initial response to first-line hormonal treatment, most patients with metastatic prostate cancer will succumb to a hormone-refractory form of the disease. Because these tumors are still dependent on ...
- beta(3) Integrin Subunit Mediates the Bone-Resorbing Function Exerted by Cultured Myeloma Plasma Cells
[作者:Tucci, M; De Palma, R; Lombardi, L; Rodolico, G; Berrino, L; Dammacco, F; Silvestris, F,期刊:Cancer research, 页码:6738-6746 , 文章类型: Article,,卷期:2009年69-16]
- alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)be...
- Osteoclast-Derived Matrix Metalloproteinase-7, but Not Matrix Metalloproteinase-9, Contributes to Tumor-Induced Osteolysis
[作者:Thiolloy, S; Halpern, J; Holt, GE; Schwartz, HS; Mundy, GR; Matrisian, LM; Lynch, CC,期刊:Cancer research, 页码:6747-6755 , 文章类型: Article,,卷期:2009年69-16]
- The matrix metalloproteinases MMP-2, MMP-3, MMP-7, MMP-9, and MMP-13 are highly expressed in the tumor-bone microenvironment, and, of these, MMP-7 and MMP-9 were found to be localized to bone-resorbing osteoclasts in hum...
- microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis (vol 69, pg 5970, 2009)
[作者:Hoffman, AE; Zheng, T; Yi, C; Leaderer, D; Weidhaas, J; Slack, F; Zhang, Y; Paranjape, T; Zhu, Y,期刊:Cancer research, 页码:6758-6758 , 文章类型: Correction,,卷期:2009年69-16]
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- Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation (vol 69, pg 5851, 2009)
[作者:Talavera, A; Friemann, R; Gomez-Puerta, S; Martinez-Fleites, C; Garrido, G; Rabasa, A; Lopez-Requena, A; Pupo, A; Johansen, RF; Sanchez, O; Krengel, U; Moreno, E,期刊:Cancer research, 页码:6758-6758 , 文章类型: Correction,,卷期:2009年69-16]
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- A Nanoparticle System Specifically Designed to Deliver Short Interfering RNA Inhibits Tumor Growth In vivo
[作者:Yagi, N; Manabe, I; Tottori, T; Ishihara, A; Ogata, F; Kim, JH; Nishimura, S; Fujiu, K; Oishi, Y; Itaka, K; Kato, Y; Yamauchi, M; Nagai, R,期刊:Cancer research, 页码:6531-6538 , 文章类型: Article,,卷期:2009年69-16]
- Use of short interfering RNA (siRNA) is a promising new approach thought to have a strong potential to lead to rapid development of gene-oriented therapies. Here, we describe a newly developed, systemically injectable si...
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