- Proteomic and Genetic Approaches Identify Syk as an AML Target
[作者：Hahn, CK; Berchuck, JE; Ross, KN; Kakoza, RM; Clauser, K; Schinzel, AC; Ross, L; Galinsky, I; Davis, TN; Silver, SJ; Root, DE; Stone, RM; DeAngelo, DJ; Carroll, M; Hahn, WC; Carr, SA; Golub, TR; Kung, AL; Stegmaier, K,期刊：Cancer Cell, 页码：281-294 , 文章类型： Article，,卷期：2009年16-4]
- Cell-based screening can facilitate the rapid identification of compounds inducing complex cellular phenotypes. Advancing a compound toward the clinic, however, generally requires the identification of precise mechanisms...
- A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma
[作者：Haybaeck, J; Zeller, N; Wolf, MJ; Weber, A; Wagner, U; Kurrer, MO; Bremer, J; Iezzi, G; Graf, R; Clavien, PA; Thimme, R; Blum, H; Nedospasov, SA; Zatloukal, K; Ramzan, M; Ciesek, S; Pietschmann, T; Marche, PN; Karin, M; Kopf, M; Browning, JL; Aguzzi, A; Heikenwalder, M,期刊：Cancer Cell, 页码：295-308 , 文章类型： Article，,卷期：2009年16-4]
- Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines; lymphotoxin (LT) alpha and beta and their receptor (LTOR) are up...
- Functional Interaction of Plasmacytoid Dendritic Cells with Multiple Myeloma Cells: A Therapeutic Target
[作者：Chauhan, D; Singh, AV; Brahmandam, M; Carrasco, R; Bandi, M; Hideshima, T; Bianchi, G; Podar, K; Tai, YT; Mitsiades, C; Raje, N; Jaye, DL; Kumar, SK; Richardson, P; Munshi, N; Anderson, KC,期刊：Cancer Cell, 页码：309-323 , 文章类型： Article，,卷期：2009年16-4]
- Multiple myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. Using both in vitro and in vivo MM xenograft models,...
- Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate
[作者：Wang, LZ; Liu, RH; Li, WQ; Chen, C; Katoh, H; Chen, GY; McNally, B; Lin, L; Zhou, PH; Zuo, T; Cooney, KA; Liu, Y; Zheng, P,期刊：Cancer Cell, 页码：336-346 , 文章类型： Article，,卷期：2009年16-4]
- Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 ...
- Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly
[作者：Huang, HC; Shi, J; Orth, JD; Mitchison, TJ,期刊：Cancer Cell, 页码：347-358 , 文章类型： Article，,卷期：2009年16-4]
- Current antimitotics work by perturbing spindle assembly, which activates the spindle assembly checkpoint, causes mitotic arrest, and triggers apoptosis. Cancer cells can resist such killing by premature exit, before cel...
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