- DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia
[作者：Figueroa, ME; Lugthart, S; Li, YS; Erpelinck-Verschueren, C; Deng, XT; Christos, PJ; Schifano, E; Booth, J; van Putten, W; Skrabanek, L; Campagne, F; Mazumdar, M; Greally, JM; Valk, PJM; Lowenberg, B; Delwel, R; Melnick, A,期刊：Cancer Cell, 页码：13-27 , 文章类型： Article，,卷期：2010年17-1]
- We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid le...
- The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia
[作者：Klein, U; Lia, M; Crespo, M; Siegel, R; Shen, Q; Mo, TW; Ambesi-Impiombato, A; Califano, A; Migliazza, A; Bhagat, G; Dalla-Favera, R,期刊：Cancer Cell, 页码：28-40 , 文章类型： Article，,卷期：2010年17-1]
- Chronic lymphocytic leukemia (CLL) is a malignancy of B cells of unknown etiology. Deletions of the chromosomal region 13q14 are commonly associated with CLL, with monoclonal B cell lymphocytosis (MBL), which occasionall...
- SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
[作者：Kim, HS; Patel, K; Muldoon-Jacobs, K; Bisht, KS; Aykin-Burns, N; Pennington, JD; van der Meer, R; Nguyen, P; Savage, J; Owens, KM; Vassilopoulos, A; Ozden, O; Park, SH; Singh, KK; Abdulkadir, SA; Spitz, DR; Deng, CX; Gius, D,期刊：Cancer Cell, 页码：41-52 , 文章类型： Article，,卷期：2010年17-1]
- The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial ph...
- IAP Regulation of Metastasis
[作者：Mehrotra, S; Languino, LR; Raskett, CM; Mercurio, AM; Dohi, T; Altieri, DC,期刊：Cancer Cell, 页码：53-64 , 文章类型： Article，,卷期：2010年17-1]
- Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cel...
- Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis
[作者：Jeselsohn, R; Brown, NE; Arendt, L; Klebba, I; Hu, MG; Kuperwasser, C; Hinds, PW,期刊：Cancer Cell, 页码：65-76 , 文章类型： Article，,卷期：2010年17-1]
- Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to self renew and regenerate a functional mammary gland. Although these progenitors are the likely targets for oncogeni...
- Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC
[作者：Turke, AB; Zejnullahu, K; Wu, YL; Song, Y; Dias-Santagata, D; Lifshits, E; Toschi, L; Rogers, A; Mok, T; Sequist, L; Lindeman, NI; Murphy, C; Akhavanfard, S; Yeap, BY; Xiao, Y; Capelletti, M; Iafrate, AJ; Lee, C; Christensen, JG; Engelman, JA; Janne, PA,期刊：Cancer Cell, 页码：77-88 , 文章类型： Article，,卷期：2010年17-1]
- MET amplification activates ERBB3/PI3K/AKT signaling in EGFR mutant lung cancers and causes resistance to EGFR kinase inhibitors. We demonstrate that MET activation by its ligand, HGF, also induces drug resistance, but t...
- Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKK beta- and JNK1-Dependent Inflammation
[作者：Takahashi, H; Ogata, H; Nishigaki, R; Broide, DH; Karin, M,期刊：Cancer Cell, 页码：89-97 , 文章类型： Article，,卷期：2010年17-1]
- Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of cancer-related deaths worldwide. It is we...
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
[作者：Verhaak, RGW; Hoadley, KA; Purdom, E; Wang, V; Qi, Y; Wilkerson, MD; Miller, CR; Ding, L; Golub, T; Mesirov, JP; Alexe, G; Lawrence, M; O'Kelly, M; Tamayo, P; Weir, BA; Gabriel, S; Winckler, W; Gupta, S; Jakkula, L; Feiler, HS; Hodgson, JG; James, CD; Sarkaria, JN; Brennan, C; Kahn, A; Spellman, PT; Wilson, RK; Speed, TP; Gray, JW; Meyerson, M; Getz, G; Perou, CM; Hayes, DN,期刊：Cancer Cell, 页码：98-110 , 文章类型： Article，,卷期：2010年17-1]
- The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Clas...
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