- FcR gamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis
[作者：Andreu, P; Johansson, M; Affara, NI; Pucci, F; Tan, TT; Junankar, S; Korets, L; Lam, J; Tawfik, D; DeNardo, DG; Naldini, L; de Visser, KE; De Palma, M; Coussens, LM,期刊：Cancer Cell, 页码：121-134 , 文章类型： Article，,卷期：2010年17-2]
- Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells re...
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappa B-Dependent Manner
[作者：Erez, N; Truitt, M; Olson, P; Hanahan, D,期刊：Cancer Cell, 页码：135-147 , 文章类型： Article，,卷期：2010年17-2]
- Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion. We demonstrate that CAFs also mediate tumor-enhancing inflammation. Using a mouse model of ...
- MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
[作者：Thiel, AT; Blessington, P; Zou, T; Feather, D; Wu, XJ; Yan, JZ; Zhang, H; Liu, ZG; Ernst, P; Koretzky, GA; Hua, XX,期刊：Cancer Cell, 页码：148-159 , 文章类型： Article，,卷期：2010年17-2]
- Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocat...
- Matrix Metalloproteinase-9 Promotes Chronic Lymphocytic Leukemia B Cell Survival through Its Hemopexin Domain
[作者：Redondo-Munoz, J; Ugarte-Berzal, E; Terol, MJ; Van den Steen, PE; del Cerro, MH; Roderfeld, M; Roeb, E; Opdenakker, G; Garcia-Marco, JA; Garcia-Pardo, A,期刊：Cancer Cell, 页码：160-172 , 文章类型： Article，,卷期：2010年17-2]
- Matrix metalloproteinase-9 (MMP-9) is the major MMP produced by B-CLL cells and contributes to their tissue infiltration by degrading extracellular and membrane-anchored substrates. Here we describe a different function ...
- PML-RAR alpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia
[作者：Martens, JHA; Brinkman, AB; Simmer, F; Francoijs, KJ; Nebbioso, A; Ferrara, F; Altucci, L; Stunnenberg, HG,期刊：Cancer Cell, 页码：173-185 , 文章类型： Article，,卷期：2010年17-2]
- Many different molecular mechanisms have been associated with PML-RAR alpha-dependent transformation of hematopoietic progenitors. Here, we identified high confidence PML-RAR alpha binding sites in an acute promyelocytic...
- PML/RAR alpha Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia
[作者：Wang, KK; Wang, P; Shi, JT; Zhu, XH; He, MM; Jia, XH; Yang, XW; Qiu, F; Jin, W; Qian, MX; Fang, H; Mi, JQ; Yang, XZ; Xiao, HS; Minden, M; Du, YZ; Chen, Z; Zhang, J,期刊：Cancer Cell, 页码：186-197 , 文章类型： Article，,卷期：2010年17-2]
- PML/RAR alpha is of crucial importance in acute promyelocytic leukemia (APL) both pathologically and therapeutically. Using a genome-wide approach, we identified in vivo PML/RAR alpha binding sites in a PML/RAR alpha-ind...
- A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription
[作者：Yokoyama, A; Lin, M; Naresh, A; Kitabayashi, I; Cleary, ML,期刊：Cancer Cell, 页码：198-212 , 文章类型： Article，,卷期：2010年17-2]
- AF4 and ENL family proteins are frequently fused with MLL, and they comprise a higher order complex (designated AEP) containing the P-TEFb transcription elongation factor. Here, we show that AEP is normally recruited to ...
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