- Hepatocyte IKK beta/NF-kappa B Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation
[作者:He, GB; Yu, GY; Temkin, V; Ogata, H; Kuntzen, C; Sakurai, T; Sieghart, W; Peck-Radosavljevic, M; Leffert, HL; Karin, M,期刊:Cancer Cell, 页码:286-297 , 文章类型: Article,,卷期:2010年17-3]
- The NF-kappa B activating kinase IKK beta suppresses early chemically induced liver tumorigenesis by inhibiting hepatocyte death and compensatory IKK beta's role in late tumor promotion and progression, we developed a tr...
- An Activated ErbB3/NRG1 Autocrine Loop Supports In Vivo Proliferation in Ovarian Cancer Cells
[作者:Sheng, Q; Liu, XG; Fleming, E; Yuan, K; Piao, HY; Chen, JY; Moustafa, Z; Thomas, RK; Greulich, H; Schinzel, A; Zaghlul, S; Batt, D; Ettenberg, S; Meyerson, M; Schoeberl, B; Kung, AL; Hahn, WC; Drapkin, R; Livingston, DM; Liu, JF,期刊:Cancer Cell, 页码:298-310 , 文章类型: Article,,卷期:2010年17-3]
- Ovarian cancer is a leading cause of death from gynecologic malignancies. Treatment for advanced-stage disease remains limited and, to date, targeted therapies have been incompletely explored. By systematically suppressi...
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting alpha-Ketoglutarate to 2-Hydroxyglutarate
[作者:Ward, PS; Patel, J; Wise, DR; Abdel-Wahab, O; Bennett, BD; Coller, HA; Cross, JR; Fantin, VR; Hedvat, CV; Perl, AE; Rabinowitz, JD; Carroll, M; Su, SM; Sharp, KA; Levine, RL; Thompson, CB,期刊:Cancer Cell, 页码:225-234 , 文章类型: Article,,卷期:2010年17-3]
- The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2-hydroxyglutarate (2HG). Here, we report that tumor 2HG is elevated in a high percentage of patients...
- DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
[作者:Martin, SA; McCabe, N; Mullarkey, M; Cummins, R; Burgess, DJ; Nakabeppu, Y; Oka, S; Kay, E; Lord, CJ; Ashworth, A,期刊:Cancer Cell, 页码:235-248 , 文章类型: Article,,卷期:2010年17-3]
- Synthetic sickness/lethality (SSL) can be exploited to develop therapeutic strategies for cancer. Deficiencies in the tumor suppressor proteins MLH1 and MSH2 have been implicated in cancer. Here we demonstrate that defic...
- Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E
[作者:Hsieh, AC; Costa, M; Zollo, O; Davis, C; Feldman, ME; Testa, JR; Meyuhas, O; Shokat, KM; Ruggero, D,期刊:Cancer Cell, 页码:249-261 , 文章类型: Article,,卷期:2010年17-3]
- We genetically dissect the contribution of the most prominent downstream translational components of mTOR signaling toward Akt-driven lymphomagenesis. While phosphorylation of rpS6 is dispensable for cancer formation, 4E...
- Tumor Stroma-Derived TGF-beta Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
[作者:Reimann, M; Lee, S; Loddenkemper, C; Dorr, JR; Tabor, V; Aichele, P; Stein, H; Dorken, B; Jenuweins, T; Schmitt, CA,期刊:Cancer Cell, 页码:262-272 , 文章类型: Article,,卷期:2010年17-3]
- Activated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked DNA damage response (DDR). In contrast, Myc activation-although...
- Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
[作者:Stambolsky, P; Tabach, Y; Fontemaggi, G; Weisz, L; Maor-Aloni, R; Sigfried, Z; Shiff, I; Kogan, I; Shay, M; Kalo, E; Blandino, G; Simon, I; Oren, M; Rotter, V,期刊:Cancer Cell, 页码:273-285 , 文章类型: Article,,卷期:2010年17-3]
- The p53 gene is mutated in many human tumors. Cells of such tumors often contain abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression via a gain-of-function mechanism. We applied ChIP-...
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