- Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
[作者：Zhang, B; Strauss, AC; Chu, S; Li, M; Ho, YW; Shiang, KD; Snyder, DS; Huettner, CS; Shultz, L; Holyoake, T; Bhatia, R,期刊：Cancer Cell, 页码：427-442 , 文章类型： Article，,卷期：2010年17-5]
- Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients but does not eliminate leukemia stem cells (LSCs), which remain a potential source of relapse. Here we investigated the ability of H...
- An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
[作者：Yu, JD; Yu, JJ; Mani, RS; Cao, Q; Brenner, CJ; Cao, XH; Wang, XJ; Wu, LT; Li, J; Hu, M; Gong, YS; Cheng, H; Laxman, B; Vellaichamy, A; Shankar, S; Li, Y; Dhanasekaran, SM; Morey, R; Barrette, T; Lonigro, RJ; Tomlins, SA; Varambally, S; Qin, ZS; Chinnaiyan, AM,期刊：Cancer Cell, 页码：443-454 , 文章类型： Article，,卷期：2010年17-5]
- Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but how the fusion products regulate prostate cancer rem...
- Accelerated Leukemogenesis by Truncated CBF beta-SMMHC Defective in High-Affinity Binding with RUNX1
[作者：Kamikubo, Y; Zhao, L; Wunderlich, M; Corpora, T; Hyde, RK; Paul, TA; Kundu, M; Garrett, L; Compton, S; Huang, G; Wolff, L; Ito, Y; Bushweller, J; Mulloy, JC; Liu, PP,期刊：Cancer Cell, 页码：455-468 , 文章类型： Article，,卷期：2010年17-5]
- Dominant RUNX1 inhibition has been proposed as a common pathway for CBF leukemia. CBF beta-SMMHC, a fusion protein in human acute myeloid leukemia (AML), dominantly inhibits RUNX1 largely through its RUNX1 high-affinity ...
- Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2
[作者：Li, BH; Gordon, GM; Du, CH; Xu, JH; Du, W,期刊：Cancer Cell, 页码：469-480 , 文章类型： Article，,卷期：2010年17-5]
- The retinoblastoma (Rb) tumor suppressor is often inactivated in cancers. To identify genes that can be used to specifically target such cancers, we carried out a genetic screen in Drosophila. We identified gig (fly TSC2...
- TAK1 Suppresses a NEMO-Dependent but NF-kappa B-Independent Pathway to Liver Cancer
[作者：Bettermann, K; Vucur, M; Haybaeck, J; Koppe, C; Janssen, J; Heymann, F; Weber, A; Weiskirchen, R; Liedtke, C; Gassler, N; Muller, M; de Vos, R; Wolf, MJ; Boege, Y; Seleznik, GM; Zeller, N; Erny, D; Fuchs, T; Zoller, S; Cairo, S; Buendia, MA; Prinz, M; Akira, S; Tacke, F; Heikenwalder, M; Trautwein, C; Luedde, T,期刊：Cancer Cell, 页码：481-496 , 文章类型： Article，,卷期：2010年17-5]
- The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that cond...
- PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas
[作者：Zheng, HW; Ying, HQ; Wiedemeyer, R; Yan, HY; Quayle, SN; Ivanova, EV; Paik, JH; Zhang, HL; Xiao, YH; Perry, SR; Hu, J; Vinjamoori, A; Gan, BY; Sahin, E; Chheda, MG; Brennan, C; Wang, YA; Hahn, WC; Chin, L; DePinho, RA,期刊：Cancer Cell, 页码：497-509 , 文章类型： Article，,卷期：2010年17-5]
- A hallmark feature of glioblastoma is its strong self-renewal potential and immature differentiation state, which contributes to its plasticity and therapeutic resistance. Here, integrated genomic and biological analyses...
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
[作者：Noushmehr, H; Weisenberger, DJ; Diefes, K; Phillips, HS; Pujara, K; Berman, BP; Pan, F; Pelloski, CE; Sulman, EP; Bhat, KP; Verhaak, RGW; Hoadley, KA; Hayes, DN; Perou, CM; Schmidt, HK; Ding, L; Wilson, RK; Van Den Berg, D; Shen, H; Bengtsson, H; Neuvial, P; Cope, LM; Buckley, J; Herman, JG; Baylin, SB; Laird, PW; Aldape, K,期刊：Cancer Cell, 页码：510-522 , 文章类型： Article，,卷期：2010年17-5]
- We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large...
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