Structure————————个性化文献订阅—

Optically Resolving Individual Microtubules in Live Axons
[作者：Mudrakola, HV; Zhang, K; Cui, BX,期刊：Structure, 页码：1433-1441 , 文章类型： Article，,卷期：2009年17-11]
Microtubules are essential cytoskeletal tracks for cargo transportation in axons and also serve as the primary structural scaffold of neurons. Structural assembly, stability, and dynamics of axonal microtubules are of gr...

Cryo-EM Reveals Promoter DNA Binding and Conformational Flexibility of the General Transcription Factor TFIID
[作者：Elmlund, H; Baraznenok, V; Linder, T; Szilagyi, Z; Rofougaran, R; Hofer, A; Hebert, H; Lindahl, M; Gustafsson, CM,期刊：Structure, 页码：1442-1452 , 文章类型： Article，,卷期：2009年17-11]
The general transcription factor IID (TFIID) is required for initiation of RNA polymerase II-dependent transcription at many eukaryotic promoters. TFIID comprises the TATA-binding protein (TBP) and several conserved TBP-...

Regulation of the Protein-Conducting Channel by a Bound Ribosome
[作者：Gumbart, J; Trabuco, LG; Schreiner, E; Villa, E; Schulten, K,期刊：Structure, 页码：1453-1464 , 文章类型： Article，,卷期：2009年17-11]
During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural da...

Crystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut Case
[作者：Aleshin, AE; Gramatikova, S; Hura, GL; Bobkov, A; Strongin, AY; Stec, B; Tainer, JA; Liddington, RC; Smith, JW,期刊：Structure, 页码：1465-1475 , 文章类型： Article，,卷期：2009年17-11]
The M16 family of zinc peptidases comprises a pair of homologous domains that form two halves of a "clam-shell" surrounding the active site. The M16A and M16C subfamilies form one class ("peptidasomes"): they degrade 30-...

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1
[作者：Huang, RH; Fremont, DH; Diener, JL; Schaub, RG; Sadler, JE,期刊：Structure, 页码：1476-1484 , 文章类型： Article，,卷期：2009年17-11]
ARC1172 is a 41-mer DNA aptamer selected to bind the A1 domain of von Willebrand factor (VWF). A derivative of ARC1172 with modifications to increase intravascular survival inhibits carotid artery thrombosis in a Cynomol...

Specific Arrangement of alpha-Helical Coiled Coils in the Core Domain of the Bacterial Flagellar Hook for the Universal Joint Function
[作者：Fujii, T; Kato, T; Namba, K,期刊：Structure, 页码：1485-1493 , 文章类型： Article，,卷期：2009年17-11]
The bacterial flagellar hook is a short, highly curved tubular structure connecting the rotary motor to the filament acting as a helical propeller. The bending flexibility of the hook allows it to work as a universal joi...

Ligand Migration and Cavities within Scapharca Dimeric Hbl: Studies by Time-Resolved Crystallography, Xe Binding, and Computational Analysis
[作者：Knapp, JE; Pahl, R; Cohen, J; Nichols, JC; Schulten, K; Gibson, QH; Srajer, V; Royer, WE,期刊：Structure, 页码：1494-1504 , 文章类型： Article，,卷期：2009年17-11]
As in many other hemoglobins, no direct route for migration of ligands between solvent and active site is evident from crystal structures of Scapharca inaequivalvis dimeric Hbl. Xenon (Xe) and organic halide binding expe...

Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations
[作者：Lobo, PA; Van Petegem, F,期刊：Structure, 页码：1505-1514 , 文章类型： Article，,卷期：2009年17-11]
Ryanodine receptors (RyRs) are channels governing the release of Ca2+ from the sarcoplasmic or endoplasmic reticulum. They are required for the contraction of both skeletal (RyR1) and cardiac (RyR2) muscles. Mutations...

Predicting Continuous Local Structure and the Effect of Its Substitution for Secondary Structure in Fragment-Free Protein Structure Prediction
[作者：Faraggi, E; Yang, YD; Zhang, SS; Zhou, YQ,期刊：Structure, 页码：1515-1527 , 文章类型： Article，,卷期：2009年17-11]
Local structures predicted from protein sequences are used extensively in every aspect of modeling and prediction of protein structure and function. For more than 50 years, they have been predicted at a low-resolution co...

Structural Basis for Targeting of Human RNA Helicase DDX3 by Poxvirus Protein K7
[作者：Oda, S; Schroder, M; Khan, AR,期刊：Structure, 页码：1528-1537 , 文章类型： Article，,卷期：2009年17-11]
Poxviruses are DNA viruses that express numerous proteins to subvert the host immune response. Vaccinia virus protein K7 adopts a Bcl-2 fold and displays structural and functional similarities to Toll-like receptor antag...

Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens
[作者：Burke, V; Williams, C; Sukumaran, M; Kim, SS; Li, HG; Wang, XH; Gorny, MK; Zolla-Pazner, S; Kong, XP,期刊：Structure, 页码：1538-1546 , 文章类型： Article，,卷期：2009年17-11]
Human monoclonal antibodies 447-52D and 537-10D, both coded by the VH3 gene and specific for the third variable region (V3) of the HIV-1 gp120, were found to share antigen-binding structural elements including an elongat...