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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Structure of Concatenated HAMP Domains Provides a Mechanism for Signal Transduction [作者：Airola, MV; Watts, KJ; Bilwes, AM; Crane, BR,期刊：Structure, 页码：436-448 , 文章类型： Article，,卷期：2010年18-4] HAMP domains are widespread prokaryotic signaling modules found as single domains or poly-HAMP chains in both transmembrane and soluble proteins. The crystal structure of a three-unit poly-HAMP chain from the Pseudomonas... Structure of the RNA 3 '-Phosphate Cyclase-Adenylate Intermediate Illuminates Nucleotide Specificity and Covalent Nucleotidyl Transfer [作者：Tanaka, N; Smith, P; Shuman, S,期刊：Structure, 页码：449-457 , 文章类型： Article，,卷期：2010年18-4] RNA 3'-phosphate cyclase (RtcA) synthesizes RNA 2',3' cyclic phosphate ends via three steps: reaction with ATP to form a covalent RtcA-AMP intermediate; transfer of adenylate to an RNA 3'-phosphate to form RNA(3')pp(5')A... Dynameomics: A Comprehensive Database of Protein Dynamics [作者：van der Kamp, MW; Schaeffer, RD; Jonsson, AL; Scouras, AD; Simms, AM; Toofanny, RD; Benson, NC; Anderson, PC; Merkley, ED; Rysavy, S; Bromley, D; Beck, DAC; Daggett, V,期刊：Structure, 页码：423-435 , 文章类型： Article，,卷期：2010年18-4] The dynamic behavior of proteins is important for an understanding of their function and folding. We have performed molecular dynamics simulations of the native state and unfolding pathways of over 2000 protein/peptide s... Pi Release from Myosin: A Simulation Analysis of Possible Pathways [作者：Cecchini, M; Alexeev, Y; Karplus, M,期刊：Structure, 页码：458-470 , 文章类型： Article，,卷期：2010年18-4] The release of phosphate (Pi) is an important element in actomyosin function and has been shown to be accelerated by the binding of myosin to actin. To provide information about the structural elements important for Pi r... Rigor to Post-Rigor Transition in Myosin V: Link between the Dynamics and the Supporting Architecture [作者：Tehver, R; Thirumalai, D,期刊：Structure, 页码：471-481 , 文章类型： Article，,卷期：2010年18-4] The detachment kinetics from actin upon ATP binding is a key step in the reaction cycle of myosin V. We show that a network of residues, constituting the allostery wiring diagram (AWD), that trigger the rigor (R) to post... The Human Breast Cancer Resistance Protein (BCRP/ABCG2) Shows Conformational Changes with Mitoxantrone [作者：Rosenberg, MF; Bikadi, Z; Chan, J; Liu, XP; Ni, ZL; Cai, XK; Ford, RC; Mao, QC,期刊：Structure, 页码：482-493 , 文章类型： Article，,卷期：2010年18-4] BCRP/ABCG2 mediates efflux of drugs and xenobiotics. BCRP was expressed in Pichia pastoris, purified to > 90% homogeneity, and subjected to two-dimensional (2D) crystallization. The 2D crystals showed a p12(1) symmetry a... Structural Insights into the COP9 Signalosome and Its Common Architecture with the 26S Proteasome Lid and eIF3 [作者：Enchev, RI; Schreiber, A; Beuron, F; Morris, EP,期刊：Structure, 页码：518-527 , 文章类型： Article，,卷期：2010年18-4] The evolutionary conserved COP9 signalosome (CSN), a large multisubunit complex, plays a central role in regulating ubiquitination and cell signaling. Here we report recombinant insect cell expression and two-step purifi... Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase [作者：Mittag, T; Marsh, J; Grishaev, A; Orlicky, S; Lin, H; Sicheri, F; Tyers, M; Forman-Kay, JD,期刊：Structure, 页码：494-506 , 文章类型： Article，,卷期：2010年18-4] Intrinsically disordered proteins can form highly dynamic complexes with partner proteins. One such dynamic complex involves the intrinsically disordered Sic1 with its partner Cdc4 in regulation of yeast cell cycle progr... Structural and Dynamical Insights into the Opening Mechanism of P. aeruginosa OprM Channel [作者：Phan, G; Benabdelhak, H; Lascombe, MB; Benas, P; Rety, S; Picard, M; Ducruix, A; Etchebest, C; Broutin, I,期刊：Structure, 页码：507-517 , 文章类型： Article，,卷期：2010年18-4] Originally described in bacteria, drug transporters are now recognized as major determinants in antibiotics resistance. For Gram-negative bacteria, the reversible assembly consisting of an inner membrane protein responsi... Structure of a Virulence Regulatory Factor CvfB Reveals a Novel Winged Helix RNA Binding Module [作者：Matsumoto, Y; Xu, QP; Miyazaki, S; Kaito, C; Farr, CL; Axelrod, HL; Chiu, HJ; Klock, HE; Knuth, MW; Miller, MD; Elsliger, MA; Deacon, AM; Godzik, A; Lesley, SA; Sekimizu, K; Wilson, IA,期刊：Structure, 页码：537-547 , 文章类型： Article，,卷期：2010年18-4] CvfB is a conserved regulatory protein important for the virulence of Staphylococcus aureus. We show here that CvfB binds RNA. The crystal structure of the CvfB ortholog from Streptococcus pneumoniae at 1.4 angstrom reso... Structural Insight into the Sequence Dependence of Nucleosome Positioning [作者：Wu, B; Mohideen, K; Vasudevan, D; Davey, CA,期刊：Structure, 页码：528-536 , 文章类型： Article，,卷期：2010年18-4] Nucleosome positioning displays sequence dependency and contributes to genomic regulation in a site-specific manner. We solved the structures of nucleosome core particle composed of strong positioning TTTAA elements flan...