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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Dynamics of SecY Translocons with Translocation-Defective Mutations [作者：Bondar, AN; del Val, C; Freites, JA; Tobias, DJ; White, SH,期刊：Structure, 页码：847-857 , 文章类型： Article，,卷期：2010年18-7] The SecY/Sec61 translocon complex, located in the endoplasmic reticulum membrane of eukaryotes (Sec61) or the plasma membrane of prokaryotes (SecY), mediates the transmembrane secretion or insertion of nascent proteins. ... Recognizing Protein Substructure Similarity Using Segmental Threading [作者：Wu, ST; Zhang, Y,期刊：Structure, 页码：858-867 , 文章类型： Article，,卷期：2010年18-7] Protein template identification is essential to protein structure and function predictions. However, conventional whole-chain threading approaches often fail to recognize conserved substructure motifs when the target and... Structural Dynamics of the Magnesium-Bound Conformation of CorA in a Lipid Bilayer [作者：Dalmas, O; Cuello, LG; Jogini, V; Cortes, DM; Roux, B; Perozo, E,期刊：Structure, 页码：868-878 , 文章类型： Article，,卷期：2010年18-7] The transmembrane conformation of Thermotoga maritima CorA, a magnesium transport system, has been studied in its Mg2+-bound form by site-directed spin labeling and electron paramagnetic resonance spectroscopy. Probe mob... Why an A-Loop Phospho-Mimetic Fails to Activate PAK1: Understanding an Inaccessible Kinase State by Molecular Dynamics Simulations [作者：Ng, YW; Raghunathan, D; Chan, PM; Baskaran, Y; Smith, DJ; Lee, CH; Verma, C; Manser, E,期刊：Structure, 页码：879-890 , 文章类型： Article，,卷期：2010年18-7] Crystal structures of inactive PAK1(K299R) and the activation (A)-loop phospho-mimetic PAK1(T423E) have suggested that the kinase domain is in an active state regardless of activation loop status. Contrary to a large bod... Multiple Conformations of F-actin [作者：Oda, T; Maeda, Y,期刊：Structure, 页码：761-767 , 文章类型： Review，,卷期：2010年18-7] Actin works within eukaryotic cells to facilitate a variety of cellular processes, which are driven by the assembly of G-actin (monomeric form) into F-actin (fibrous form), and the disassembly of F-actin into G-actin. F-... Definition and Estimation of Resolution in Single-Particle Reconstructions [作者：Liao, HY; Frank, J,期刊：Structure, 页码：768-775 , 文章类型： Review，,卷期：2010年18-7] In this paper, we review current practices for establishing the resolution in single-particle reconstructions. The classical Raleigh criterion for the resolution is not applicable in this case, and the resolution is comm... Ab Initio Structure Determination from Electron Microscopic Images of Single Molecules Coexisting in Different Functional States [作者：Elmlund, D; Davis, R; Elmlund, H,期刊：Structure, 页码：777-786 , 文章类型： Article，,卷期：2010年18-7] We have developed methods for ab initio three-dimensional (3D) structure determination from projection images of randomly oriented single molecules coexisting in multiple functional states, to aid the study of complex sa... Free State Conformational Sampling of the SAM-I Riboswitch Aptamer Domain [作者：Stoddard, CD; Montange, RK; Hennelly, SP; Rambo, RP; Sanbonmatsu, KY; Batey, RT,期刊：Structure, 页码：787-797 , 文章类型： Article，,卷期：2010年18-7] Riboswitches are highly structured elements residing in the 5' untranslated region of messenger RNAs that specifically bind cellular metabolites to alter gene expression. While there are many structures of ligand-bound r... Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations [作者：Kimber, MS; Yu, AYH; Borg, M; Leung, E; Chan, HS; Houry, WA,期刊：Structure, 页码：798-808 , 文章类型： Article，,卷期：2010年18-7] The highly conserved ClpP protease consists of two heptameric rings that interact by the interdigitation of an alpha-helix beta strand handle domain motif to form a tetradecameric cylinder. We previously proposed that pr... An Active Site Water Network in the Plasminogen Activator Pla from Yersinia pestis [作者：Eren, E; Murphy, M; Goguen, J; van den Berg, B,期刊：Structure, 页码：809-818 , 文章类型： Article，,卷期：2010年18-7] The plasminogen activator Pla from Yersinia pestis is an outer membrane protease (omptin) that is important for the virulence of plague. Here, we present the high-resolution crystal structure of wild-type, enzymatically ... Thermophilic Adaptation of Protein Complexes Inferred from Proteomic Homology Modeling [作者：Ma, BG; Goncearenco, A; Berezovsky, IN,期刊：Structure, 页码：819-828 , 文章类型： Article，,卷期：2010年18-7] As protein complexes must remain in their native conformations at habitat temperatures, thermal adaptation requires adjustment of their parts and interactions between them. Based on independent sets of structural templat... Structures of Minimal Catalytic Fragments of Topoisomerase V Reveals Conformational Changes Relevant for DNA Binding [作者：Rajan, R; Taneja, B; Mondragon, A,期刊：Structure, 页码：829-838 , 文章类型： Article，,卷期：2010年18-7] Topoisomerase V is an archaeal type I topoisomerase that is unique among topoisomerases due to presence of both topoisomerase and DNA repair activities in the same protein. It is organized as an N-terminal topoisomerase ... Conformational Changes During the Gating of a Potassium Channel Revealed by Structural Mass Spectrometry [作者：Gupta, S; Bavro, VN; D'Mello, R; Tucker, SJ; Venien-Bryan, C; Chance, MR,期刊：Structure, 页码：839-846 , 文章类型： Article，,卷期：2010年18-7] Potassium channels are dynamic proteins that undergo large conformational changes to regulate the flow of K+ ions across the cell membrane. Understanding the gating mechanism of these channels therefore requires methods ...