- Galactosylated LDL Nanoparticles: A Novel Targeting Delivery System To Deliver Antigen to Macrophages and Enhance Antigen Specific T Cell Responses
[作者:Wu, F; Wuensch, SA; Azadniv, M; Ebrahimkhani, MR; Crispe, IN,期刊:Molecular Pharmaceutics, 页码:1506-1517 , 文章类型: Article,,卷期:2009年6-5]
- We aim to define the role of Kupffer cells in intrahepatic antigen presentation, using the selective delivery of antigen to Kupffer cells rather than other populations of liver antigen-presenting cells. To achieve this w...
- In Vivo Structural Activity and Optimization Studies of Folate-Tubulysin Conjugates
[作者:Reddy, JA; Dorton, R; Dawson, A; Vetzel, M; Parker, N; Nicoson, JS; Westrick, E; Klein, PJ; Wang, Y; Vlahov, IR; Leamon, CP,期刊:Molecular Pharmaceutics, 页码:1518-1525 , 文章类型: Article,,卷期:2009年6-5]
- Herein we report on the potencies of 4 related folate-conjugated tubulysins constructed with either tubulysin B hydrazide (EC0305), tubulysin A hydrazide (EC0510), the N,O-acetal derivative of natural tubulysins; (EC0317...
- Anticancer Efficacy of Squalenoyl Gemcitabine Nanomedicine on 60 Human Tumor Cell Panel and on Experimental Tumor
[作者:Reddy, LH; Renoir, JM; Marsaud, V; Lepetre-Mouelhi, S; Desmaele, D; Couvreur, P,期刊:Molecular Pharmaceutics, 页码:1526-1535 , 文章类型: Article,,卷期:2009年6-5]
- Gemcitabine (2',2'-difluorodeoxyribofuranosylcytosine) is an anticancer nucleoside analogue active against a wide variety of solid tumors. However, following intravenous administration, this drug is rapidly inactivated b...
- Tumor Necrosis Factor Receptor-IgG Fusion Protein for Targeted Drug Delivery across the Human Blood-Brain Barrier
[作者:Hui, EKW; Boado, RJ; Pardridge, WM,期刊:Molecular Pharmaceutics, 页码:1536-1543 , 文章类型: Article,,卷期:2009年6-5]
- The tumor necrosis factor-alpha receptor (TNFR) extracellular domain (ECD) is a decoy receptor that could be developed as a neurotherapeutic for stroke, brain injury, or chronic neurodegeneration. However, the TNFR ECD i...
- Biophysical and Stabilization Studies of the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein
[作者:Cai, SM; He, F; Samra, HS; de la Maza, LM; Bottazzi, ME; Joshi, SB; Middaugh, CR,期刊:Molecular Pharmaceutics, 页码:1553-1561 , 文章类型: Article,,卷期:2009年6-5]
- Native Chlamydia trachomatis mouse pneumonitis major outer membrane protein (nMOMP) induces effective protection against genital infection in a mouse challenge model. The conformation of nMOMP is crucial to confer this p...
- Synthesis and In Vivo Antitumor Efficacy of PEGylated Poly(L-lysine) Dendrimer-Camptothecin Conjugates
[作者:Fox, ME; Guillaudeu, S; Frechet, JMJ; Jerger, K; Macaraeg, N; Szoka, FC,期刊:Molecular Pharmaceutics, 页码:1562-1572 , 文章类型: Article,,卷期:2009年6-5]
- Polymer conjugates of camptothecin (CPT) have been pursued as a solution to the difficulties present in treating cancers with CPT and its derivatives. Covalent attachment of CPT to a polymer can improve solubility, incre...
- Biophysical Interactions with Model Lipid Membranes: Applications in Drug Discovery and Drug Delivery
[作者:Peetla, C; Stine, A; Labhasetwar, V,期刊:Molecular Pharmaceutics, 页码:1264-1276 , 文章类型: Article,,卷期:2009年6-5]
- The transport of drugs or drug delivery systems across the cell membrane is a complex biological process, often difficult to understand because of its dynamic nature. In this regard, model lipid membranes, which mimic ma...
- Synthesis of a Highly Water-Soluble Derivative of Amphotericin B with Attenuated Proinflammatory Activity
[作者:Adediran, SA; Day, TP; Sil, D; Kimbrell, MR; Warshakoon, HJ; Malladi, SS; David, SA,期刊:Molecular Pharmaceutics, 页码:1582-1590 , 文章类型: Article,,卷期:2009年6-5]
- Amphotericin B (AmB), a well-known polyene antifungal agent, displays a marked tendency to self-associate and, as a consequence, exhibits very poor solubility in water. The therapeutic index of AmB is low and is associat...
- Computational Models for Drug Inhibition of the Human Apical Sodium-Dependent Bile Acid Transporter
[作者:Zheng, XW; Ekins, S; Raufman, JP; Polli, JE,期刊:Molecular Pharmaceutics, 页码:1591-1603 , 文章类型: Article,,卷期:2009年6-5]
- The human apical sodium-dependent bile acid transporter (ASBT; SLC10A2) is the primary mechanism for intestinal bile acid reabsorption. In the colon, secondary bile acids increase the risk of cancer. Therefore, drugs tha...
- Chemical and Enzymatic Stability of Amino Acid Prodrugs Containing Methoxy, Ethoxy and Propylene Glycol Linkers
[作者:Gupta, D; Gupta, SV; Lee, KD; Amidon, GL,期刊:Molecular Pharmaceutics, 页码:1604-1611 , 文章类型: Article,,卷期:2009年6-5]
- We evaluated the chemical and enzymatic stabilities of prodrugs containing methoxy, ethoxy and propylene glycol linkers in order to find a suitable linker for prodrugs of carboxylic acids with amino acids. L-Valine and L...
- Polymer-Enhanced Adenoviral Transduction of CAR-Negative Bladder Cancer Cells
[作者:Kasman, LM; Barua, S; Lu, P; Rege, K; Voelkel-Johnson, C,期刊:Molecular Pharmaceutics, 页码:1612-1619 , 文章类型: Article,,卷期:2009年6-5]
- The application of adenoviral gene therapy for cancer is limited by immune clearance of the virus as well as poor transduction efficiency, since the protein used for viral entry (CAR) serves physiological functions in ad...
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