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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Multifunctional Block Copolymer Micelles for the Delivery of In-111 to EGFR-Positive Breast Cancer Cells for Targeted Auger Electron Radiotherapy [作者：Fonge, H; Lee, H; Reilly, RM; Allen, C,期刊：Molecular Pharmaceutics, 页码：177-186 , 文章类型： Article，,卷期：2010年7-1] Block copolymer micelles (BCMs) can improve the payload delivery of therapeutic agents to tumors. Our aim was to construct hEGF-modified BCMs for the delivery of In-111 to tumor cells for Auger electron-emission radiothe... Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption [作者：Nakamura, T; Nakanishi, T; Haruta, T; Shirasaka, Y; Keogh, JP; Tamai, I,期刊：Molecular Pharmaceutics, 页码：187-195 , 文章类型： Article，,卷期：2010年7-1] Ipratropium bromide, an anticholinergic drug used for the treatment of asthma and chronic obstructive pulmonary disease, has low oral bioavailability, but systemic exposure, superior to oral administration, can be achiev... Targeted Delivery of Antisense Oligodeoxynucleotide by Transferrin Conjugated pH-Sensitive Lipopolyplex Nanoparticles: A Novel Oligonucleotide-Based Therapeutic Strategy in Acute Myeloid Leukemia [作者：Jin, Y; Liu, SJ; Yu, B; Golan, S; Koh, CG; Yang, JT; Huynh, L; Yang, XJ; Pang, JX; Muthusamy, N; Chan, KK; Byrd, JC; Talmon, Y; Lee, LJ; Lee, RJ; Marcucci, G,期刊：Molecular Pharmaceutics, 页码：196-206 , 文章类型： Article，,卷期：2010年7-1] Therapeutic use of oligodeoxynucleotides (ODNs) that hybridize to and downregulate target mRNAs encoding proteins that contribute to malignant transformation has a sound rationale, but has had an overall limited clinical... Novel Bis-platinum Complexes Endowed with an Improved Pharmacological Profile [作者：Gatti, L; Perego, P; Leone, R; Apostoli, P; Carenini, N; Corna, E; Allievi, C; Bastrup, U; De Munari, S; Di Giovine, S; Nicoli, P; Grugni, M; Natangelo, M; Pardi, G; Pezzoni, G; Singer, JW; Zunino, F,期刊：Molecular Pharmaceutics, 页码：207-216 , 文章类型： Article，,卷期：2010年7-1] Multinuclear platinum complexes are characterized by a peculiar DNA binding mode and higher cytotoxic potency than the mononuclear complexes, and efficacy against a wide range of preclinical tumor models. To reduce the h... Enhanced Laminin-Derived Peptide AG73-Mediated Liposomal Gene Transfer by Bubble Liposomes and Ultrasound [作者：Negishi, Y; Omata, D; Iijima, H; Takabayashi, Y; Suzuki, K; Endo, Y; Suzuki, R; Maruyama, K; Nomizu, M; Aramaki, Y,期刊：Molecular Pharmaceutics, 页码：217-226 , 文章类型： Article，,卷期：2010年7-1] A promising strategy as a cancer therapeutic is tumor-targeted gene delivery. The AG73 peptide derived from the laminin alpha 1 chain is a ligand for syndecans, and syndecan-2 is highly expressed in some cancer cells. In... Oxidized Mesoporous Silicon Microparticles for Improved Oral Delivery of Poorly Soluble Drugs [作者：Wang, F; Hui, H; Barnes, TJ; Barnett, C; Prestidge, CA,期刊：Molecular Pharmaceutics, 页码：227-236 , 文章类型： Article，,卷期：2010年7-1] Surface functionalized mesoporous silicon (pSi) microparticles are reported as a solid dispersion carrier for improving dissolution and enhancing the orally administered pharmacokinetics (fasted rat model) of indomethaci... Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor [作者：Boado, RJ; Zhou, QH; Lu, JZQ; Hui, EKW; Pardridge, WM,期刊：Molecular Pharmaceutics, 页码：237-244 , 文章类型： Article，,卷期：2010年7-1] Monoclonal antibodies (MAbs) are potential new therapeutics for brain diseases. However, MAbs do not cross the blood-brain barrier (BBB). The present work describes the genetic engineering of a fusion protein composed of... Inhibition of Tumor Metastasis: Functional Immune Modulation of the CUB Domain Containing Protein 1 [作者：Fukuchi, K; Steiniger, SCJ; Deryugina, E; Liu, Y; Lowery, CA; Gloeckner, C; Zhou, B; Kaufmann, GF; Quigley, JP; Janda, KD,期刊：Molecular Pharmaceutics, 页码：245-253 , 文章类型： Article，,卷期：2010年7-1] Despite significant progress and notable successes in tumor therapy, malignant disease remains an extremely difficult problem in today's health care setting. There is, however, an increasing application of new therapies ... Controlled Nitric Oxide Delivery Platform Based on S-Nitrosothiol Conjugated Interpolymer Complexes for Diabetic Wound Healing [作者：Li, Y; Lee, PI,期刊：Molecular Pharmaceutics, 页码：254-266 , 文章类型： Article，,卷期：2010年7-1] Nitric oxide (NO) is known to play a critical role in enhancing wound healing as topical NO administration has demonstrated enhanced wound healing in diabetic animal models. However, this approach has been limited by the... The Mechanism of Polyplex Internalization into Cells: Testing the GM1/Caveolin-1 Lipid Raft Mediated Endocytosis Pathway [作者：Qi, R; Mullen, DG; Baker, JR; Holl, MMB,期刊：Molecular Pharmaceutics, 页码：267-279 , 文章类型： Article，,卷期：2010年7-1] The GM1/caveolin-1 lipid raft mediated endocytosis mechanism was explored for generation 5 and 7 poly(amidoamine) dendrimer polyplexes employing the Cos-7, 293A, C6, HeLa, KB, and HepG2 cell lines. Expression levels of G... CD44-Targeted Microparticles for Delivery of Cisplatin to Peritoneal Metastases [作者：Li, SD; Howell, SB,期刊：Molecular Pharmaceutics, 页码：280-290 , 文章类型： Article，,卷期：2010年7-1] Intraperitoneal (ip) chemotherapy increases the survival of optimally debulked patients with ovarian cancer due to direct access of the drug to tumor nodules growing on the peritoneal surface. CD44 is overexpressed in ma... Stabilization of the Nitric Oxide (NO) Prodrugs and Anticancer Leads, PABA/NO and Double JS-K, through Incorporation into PEG-Protected Nanoparticles [作者：Kumar, V; Hong, SY; Maciag, AE; Saavedra, JE; Adamson, DH; Prud'homme, RK; Keefer, LK; Chakrapani, H,期刊：Molecular Pharmaceutics, 页码：291-298 , 文章类型： Article，,卷期：2010年7-1] We report the stabilization of the nitric oxide (NO) prodrugs and anticancer lead compounds, PABA/NO (O-2-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N, N-dimethylamino)diazen-1-ium-1,2-diolate) and "Double JS... Delivery of Stem Cells to Porcine Arterial Wall with Echogenic Liposomes Conjugated to Antibodies against CD34 and Intercellular Adhesion Molecule-1 [作者：Herbst, SM; Klegerman, ME; Kim, H; Qi, JB; Shelat, H; Wassler, M; Moody, MR; Yang, CM; Ge, XY; Zou, YJ; Kopechek, JA; Clubb, FJ; Kraemer, DC; Huang, SL; Holland, CK; McPherson, DD; Geng, YJ,期刊：Molecular Pharmaceutics, 页码：3-11 , 文章类型： Article，,卷期：2010年7-1] In atherosclerosis, the loss of vascular stem cells via apoptosis impairs the capacity of the vascular wall to repair or regenerate the tissue damaged by atherogenic factors. Recruitment of exogenous stem cells to the pl... Homogeneous Nanoparticles To Enhance the Efficiency of a Hydrophobic Drug, Anti hyperlipidemic Probucol, Characterized by Solid-State NMR [作者：Io, T; Fukami, T; Yamamoto, K; Suzuki, T; Xu, JD; Tomono, K; Ramamoorthy, A,期刊：Molecular Pharmaceutics, 页码：299-305 , 文章类型： Article，,卷期：2010年7-1] A low absorption in the gastrointestinal tract of hydrophobic pharmaceutical compounds in use today considerably limits their bioavailability, and therefore they are taken in large doses in order to reach the therapeutic... An Imaging-Driven Model for Liposomal Stability and Circulation [作者：Qin, SP; Seo, JW; Zhang, H; Qi, J; Curry, FRE; Ferrara, KW,期刊：Molecular Pharmaceutics, 页码：12-21 , 文章类型： Article，,卷期：2010年7-1] Simultaneous labeling of the drug compartment and shell of delivery vehicles with optical and positron emission tomography (PET) probes is developed and employed to inform a hybrid physiologically based pharmacokinetic m... Ultrasonic Nanotherapy of Pancreatic Cancer: Lessons from Ultrasound Imaging [作者：Rapoport, N; Kennedy, AM; Shea, JE; Scaife, CL; Nam, KH,期刊：Molecular Pharmaceutics, 页码：22-31 , 文章类型： Article，,卷期：2010年7-1] Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cause of cancer death in the United States, with a median survival time of only 3-6 months for forty percent of patients. Current treatments are ineffectiv...