- The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by in Vivo Imaging
[作者:Nantz, MH; Dicus, CW; Hilliard, B; Yellayi, S; Zou, SM; Hecker, JG,期刊:Molecular Pharmaceutics, 页码:786-794 , 文章类型: Article,,卷期:2010年7-3]
- We, and others, have observed that the structure of cationic lipids appears to have a significant effect on the transfection efficacy of optimized nucleic acid/cationic lipid complexes (lipoplexes) used for in vitro and ...
- Predicting the Formation and Stability of Amorphous Small Molecule Binary Mixtures from Computationally Determined Flory-Huggins Interaction Parameter and Phase Diagram
[作者:Pajula, K; Taskinen, M; Lehto, VP; Ketolainen, J; Korhonen, O,期刊:Molecular Pharmaceutics, 页码:795-804 , 文章类型: Article,,卷期:2010年7-3]
- The Flory-Huggins interaction parameter has been shown to be useful in predicting the thermodynamic miscibility of a polymer and a small molecule in a binary mixture. In the present paper, this concept was extended and e...
- ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model
[作者:Mulik, RS; Monkkonen, J; Juvonen, RO; Mahadik, KR; Paradkar, AR,期刊:Molecular Pharmaceutics, 页码:815-825 , 文章类型: Article,,卷期:2010年7-3]
- Beta amyloid plays a main role in the pathophysiology of Alzheimer's disease by inducing oxidative stress in the brain. Curcumin, a natural antioxidant, is known to inhibit beta amyloid and beta amyloid induced oxidative...
- In Vitro Analysis of Acetalated Dextran Microparticles as a Potent Delivery Platform for Vaccine Adjuvants
[作者:Bachelder, EM; Beaudette, TT; Broaders, KE; Frechet, JMJ; Albrecht, MT; Mateczun, AJ; Ainslie, KM; Pesce, JT; Keane-Myers, AM,期刊:Molecular Pharmaceutics, 页码:826-835 , 文章类型: Article,,卷期:2010年7-3]
- Toll-like receptor (TLR) agonists induce potent innate immune responses and can be used in the development of novel vaccine adjuvants. However, access to TLRs can be challenging as exemplified by TLR 7, which is located ...
- Anticoagulant Efficacy of Solid Oral Formulations Containing a New Heparin Derivative
[作者:Park, JW; Jeon, OC; Kim, SK; Al-Hilal, TA; Moon, HT; Kim, CY; Byun, Y,期刊:Molecular Pharmaceutics, 页码:836-843 , 文章类型: Article,,卷期:2010年7-3]
- The need for an efficacious and safe oral anticoagulant that does not require monitoring has been largely unmet. Many efforts have centered on preparing orally available heparin to improve patient compliance. In this stu...
- Development of a Novel Self-Microemulsifying Drug Delivery System for Reducing HIV Protease Inhibitor-Induced Intestinal Epithelial Barrier Dysfunction
[作者:Lei, BK; Zha, WB; Wang, Y; Wen, C; Studer, EJ; Wang, XA; Jin, F; Wang, GJ; Zhang, LY; Zhou, HP,期刊:Molecular Pharmaceutics, 页码:844-853 , 文章类型: Article,,卷期:2010年7-3]
- The development of HIV protease inhibitors (Pis) has been one of the most significant advances of the past decade in controlling HIV infection. Unfortunately, the benefits of HIV Pis are compromised by serious side effec...
- Growth of Itraconazole Nanofibers in Supersaturated Simulated Intestinal Fluid
[作者:Mellaerts, R; Aerts, A; Caremans, TP; Vermant, J; Van den Mooter, G; Martens, JA; Augustijns, P,期刊:Molecular Pharmaceutics, 页码:905-913 , 文章类型: Article,,卷期:2010年7-3]
- Many drug compounds have limited solubility in water. To enhance the oral bioavailability of such compounds, pharmaceutical formulations target the creation of a supersaturated solution. Release of the compound from orde...
- Half-Antibody Functionalized Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells
[作者:Hu, CMJ; Kaushal, S; Cao, HST; Aryal, S; Sartor, M; Esener, S; Bouvet, M; Zhang, LF,期刊:Molecular Pharmaceutics, 页码:914-920 , 文章类型: Article,,卷期:2010年7-3]
- Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a ...
|