- Reduced Skin Photosensitivity with meta-Tetra(hydroxyphenyl)chlorin-Loaded Micelles Based on a Poly(2-ethyl-2-oxazoline)-b-poly(D,L-lactide) Diblock Copolymer in Vivo
[作者:Shieh, MJ; Peng, CL; Chiang, WL; Wang, CH; Hsu, CY; Wang, SJJ; Lai, PS,期刊:Molecular Pharmaceutics, 页码:1244-1253 , 文章类型: Article,,卷期:2010年7-4]
- Photodynamic therapy (PDT) is a light-induced chemical reaction that produces localized tissue damage for the treatment of cancers and other nonmalignant conditions. The activation of photosensitizers in a target tissue ...
- Investigation of the Effect of Mutations of Rat Albumin on the Binding Affinity to the alpha(4)beta(1) Integrin Antagonist, 4-[1-[3-Chloro-4-[N '-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic Acid (D01-4582), Using Recombinant Rat Albumins
[作者:Ito, T; Takahashi, M; Okazaki, O; Sugiyama, Y,期刊:Molecular Pharmaceutics, 页码:1254-1259 , 文章类型: Article,,卷期:2010年7-4]
- The authors reported previously rat strain differences in plasma protein binding to alpha(4)beta(1) antagonist D01-4582, resulting in a great strain difference in its pharmacokinetics (19-fold differences in the AUC). Th...
- Thermally Controlled Intracellular Uptake System of Polymeric Micelles Possessing Poly(N-isopropylacrylamide)-Based Outer Coronas
[作者:Akimoto, J; Nakayama, M; Sakai, K; Okano, T,期刊:Molecular Pharmaceutics, 页码:926-935 , 文章类型: Article,,卷期:2010年7-4]
- Temperature-induced intracellular uptake mechanism of thermoresponsive polymeric micelles comprising poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide) (P(IPAAm-DMAAm)-b-PLA) inside cultured bovine...
- An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix
[作者:Tan, MQ; Wu, XM; Jeong, EK; Chen, QJ; Parker, DL; Lu, ZR,期刊:Molecular Pharmaceutics, 页码:936-943 , 文章类型: Article,,卷期:2010年7-4]
- Stable manganese(II) chelates are of great interest for the design and development of safe and effective non-gadolinium(III)-based targeted MRI contrast agents for MR cancer molecular imaging. In this study, a CLT1 pepti...
- Specific Detection of Gastric alpha-Antitrypsin by Immobilized Trypsin on PolyHEMA Films
[作者:Khazanov, E; Emmanuel, N; Azab, AK; Barenholz, Y; Yavin, E; Rubinstein, A,期刊:Molecular Pharmaceutics, 页码:944-952 , 文章类型: Article,,卷期:2010年7-4]
- Early diagnosis of gastric carcinoma is crucial for maximizing medical treatment efficacy. For the purpose of real time diagnosis ("virtual biopsy") of stomach malignancy we developed a polyHEMA platform capable of captu...
- Iodinated Nano Clusters as an Inhaled Computed Tomography Contrast Agent for Lung Visualization
[作者:Aillon, KL; El-Gendy, N; Dennis, C; Norenberg, JP; McDonald, J; Berkland, C,期刊:Molecular Pharmaceutics, 页码:1274-1282 , 文章类型: Article,,卷期:2010年7-4]
- Improvements to contrast media formulations may be an effective way to increase the accuracy and effectiveness of thoracic computed tomography (CT) imaging in disease evaluation. To achieve contrast enhancement in the lu...
- Silencing Heat Shock Protein 27 Decreases Metastatic Behavior of Human Head and Neck Squamous Cell Cancer Cells in Vitro
[作者:Zhu, ZK; Xu, X; Yu, YK; Graham, M; Prince, ME; Carey, TE; Sun, DX,期刊:Molecular Pharmaceutics, 页码:1283-1290 , 文章类型: Article,,卷期:2010年7-4]
- The small heat shock protein 27 (Hsp27) is a molecular chaperone that is involved in a variety of cellular functions in cancer cells. The purpose of this research is to study Hsp27 in vitro metastatic behaviors of head a...
- A Novel Poly(L-glutamic acid) Dendrimer Based Drug Delivery System with Both pH-Sensitive and Targeting Functions
[作者:Yuan, H; Luo, K; Lai, YS; Pu, YJ; He, B; Wang, G; Wu, Y; Gu, ZW,期刊:Molecular Pharmaceutics, 页码:953-962 , 文章类型: Article,,卷期:2010年7-4]
- The functionalization of pH-sensitiveness and cellular targeting is a promising strategy to fabricate drug delivery systems with high efficiency, high selectivity and low toxicity. In this paper, a poly(L-glutamic acid) ...
- Triazine Dendrimers as Nonviral Vectors for in Vitro and in Vivo RNAi: The Effects of Peripheral Groups and Core Structure on Biological Activity
[作者:Merkel, OM; Mintzer, MA; Librizzi, D; Samsonova, O; Dicke, T; Sproat, B; Garn, H; Barth, PJ; Simanek, EE; Kissel, T,期刊:Molecular Pharmaceutics, 页码:969-983 , 文章类型: Article,,卷期:2010年7-4]
A family of triazine dendrimers, differing in their core flexibility, generation number, and surface functionality, was prepared and evaluated for its ability to accomplish RNAi. The dendriplexes were analyzed with re...
- Uptake, Distribution and Diffusivity of Reactive Fluorophores in Cells: Implications toward Target Identification
[作者:Cunningham, CW; Mukhopadhyay, A; Lushington, GH; Blagg, BSJ; Prisinzano, TE; Krise, JP,期刊:Molecular Pharmaceutics, 页码:1301-1310 , 文章类型: Article,,卷期:2010年7-4]
- There is much recent interest in the application of copper-free click chemistry to study a wide range of biological events in vivo and in vitro. Specifically, azide-conjugated fluorescent probes can be used to identify t...
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