- The Immunoconjugate "Icon" Targets Aberrantly Expressed Endothelial Tissue Factor Causing Regression of Endometriosis
[作者：Krikun, G; Hu, ZW; Osteen, K; Bruner-Tran, KL; Schatz, F; Taylor, HS; Toti, P; Arcuri, F; Konigsberg, W; Garen, A; Booth, CJ; Lockwood, CJ,期刊：American Journal of Pathology, 页码：1050-1056 , 文章类型： Article，,卷期：2010年176-2]
- Endometriosis is a major cause of chronic pain, infertility, medical and surgical interventions, and health care expenditures. Tissue factor (TF), the primary initiator of coagulation and a modulator of angiogenesis, is ...
- Perforin-Independent Extracellular Granzyme B Activity Contributes to Abdominal Aortic Aneurysm
[作者：Chamberlain, CM; Ang, LS; Boivin, WA; Cooper, DM; Williams, SJ; Zhao, HY; Hendel, A; Folkesson, M; Swedenborg, J; Allard, MF; McManus, BM; Granville, DJ,期刊：American Journal of Pathology, 页码：1038-1049 , 文章类型： Article，,卷期：2010年176-2]
- Granzyme B (GZMB) is a serine protease that is abundantly expressed in advanced human atherosclerotic lesions and may contribute to plaque instability. Perforin is a pore-forming protein that facilitates GZMB internaliza...
- Prenatal Exposure to apoE Deficiency and Postnatal Hypercholesterolemia Are Associated with Altered Cell-Specific Lysine Methyltransferase and Histone Methylation Patterns in the Vasculature
[作者：Alkemade, FE; van Vliet, P; Henneman, P; van Dijk, KW; Hierck, BP; van Munsteren, JC; Scheerman, JA; Goeman, JJ; Havekes, LM; Gittenberger-de Groot, AC; van den Elsen, PJ; DeRuiter, MC,期刊：American Journal of Pathology, 页码：542-548 , 文章类型： Article，,卷期：2010年176-2]
- We recently demonstrated that neointima formation of adult heterozygous apolipoprotein E (apoE(+/-)) offspring from hypercholesterolemic apoE(-/-) mothers was significantly increased as compared with genetically identica...
- The Sex-Determining Region Y-Box 4 and Homeobox C6 Transcriptional Networks in Prostate Cancer Progression Crosstalk with the Wnt, Notch, and PI3K Pathways
[作者：Moreno, CS,期刊：American Journal of Pathology, 页码：518-527 , 文章类型： Article，,卷期：2010年176-2]
- The transforming growth factor beta, Hedgehog, Notch, and Writ signaling pathways all play critical roles in the development and progression of prostate cancer. It is becoming increasingly apparent that these pathways ma...
- Ectopic T-Cell Specificity and Absence of Perforin and Granzyme B Alleviate Neural Damage in Oligodendrocyte Mutant Mice
[作者：Kroner, A; Ip, CW; Thalhammer, J; Nave, KA; Martini, R,期刊：American Journal of Pathology, 页码：549-555 , 文章类型： Article，,卷期：2010年176-2]
- In transgenic mice overexpressing the major myelin protein of the central nervous system, proteolipid protein, CD8+ T-lymphocytes mediate the primarily genetically caused myelin and axon damage. in the present study, we ...
- Structural Typing of Systemic Amyloidoses by Luminescent-Conjugated Polymer Spectroscopy
[作者：Nilsson, KPR; Ikenberg, K; Aslund, A; Fransson, S; Konradsson, P; Rocken, C; Moch, H; Aguzzi, A,期刊：American Journal of Pathology, 页码：563-574 , 文章类型： Article，,卷期：2010年176-2]
- Most systemic amyloidoses are progressive and lethal, and their therapy depends on the identification of the offending proteins. Here we report that luminescent-conjugated thiophene polymers (LCP) sensitively detect amyl...
- Tissue Deposits of IgA-Binding Streptococcal M Proteins in IgA Nephropathy and Henoch-Schonlein Purpura
[作者：Schmitt, R; Carlsson, F; Morgelin, M; Tati, R; Lindahl, G; Karpman, D,期刊：American Journal of Pathology, 页码：608-618 , 文章类型： Article，,卷期：2010年176-2]
- IgA nephropathy (IgAN) and Henoch-Schonlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms gover...
- Remodeling of the Fetal Collecting Duct Epithelium
[作者：Hiatt, MJ; Ivanova, L; Toran, N; Tarantal, AF; Matsell, DG,期刊：American Journal of Pathology, 页码：630-637 , 文章类型： Article，,卷期：2010年176-2]
- Congenital urinary tract obstruction induces changes to the renal collecting duct epithelium, including alteration and depletion of intercalated cells. To study the effects of obstruction on the ontogeny of intercalated ...
- eNOS Knockout Mice with Advanced Diabetic Nephropathy Have Less Benefit from Renin-Angiotensin Blockade than from Aldosterone Receptor Antagonists
[作者：Kosugi, T; Heinig, M; Nakayama, T; Matsuo, S; Nakagawa, T,期刊：American Journal of Pathology, 页码：619-629 , 文章类型： Article，,卷期：2010年176-2]
- While blockade of the renin angiotensin system (RAS) is beneficial in treating many patients with diabetic nephropathy, some patients show a poor response. We hypothesized that the poor response of RAS blockade is attrib...
- Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-Nuclear Factor-kappa B Pathway
[作者：Li, J; Gong, LY; Song, LB; Jiang, LL; Liu, LP; Wu, JH; Yuan, J; Cai, JC; He, M; Wang, L; Zeng, MS; Cheng, SY; Li, MF,期刊：American Journal of Pathology, 页码：699-709 , 文章类型： Article，,卷期：2010年176-2]
- One of the features of malignant gliomas is their deviant resistance to cellular apoptosis induced by cytotoxic reagents. Bmi-1, an oncoprotein, has been linked to oncogenesis; and cancer progression in various types of ...
- Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-alpha-Induced Pulmonary Fibrosis
[作者：Le Cras, TD; Korfhagen, TR; Davidson, C; Schmidt, S; Fenchel, M; Ikegami, M; Whitsett, JA; Hardie, WD,期刊：American Journal of Pathology, 页码：679-686 , 文章类型： Article，,卷期：2010年176-2]
- Transforming growth factor-alpha (TGF alpha) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human lung disease and animal models of pulmona...
- Involvement of Wnt Signaling in Dermal Fibroblasts
[作者：Kabashima, K; Sakabe, J; Yoshiki, R; Tabata, Y; Kohno, K; Tokura, Y,期刊：American Journal of Pathology, 页码：721-732 , 文章类型： Article，,卷期：2010年176-2]
- Pachydermoperiostosis (PDP) is a rare disease characterized by unique phenotypes of the skin and bone, such as thick skin, implying that it may be caused by dysregulation of mesenchymal cells. The aim of this study is to...
- Liver-Specific beta-Catenin Knockout Mice Exhibit Defective Bile Acid and Cholesterol Homeostasis and Increased Susceptibility to Diet-Induced Steatohepatitis
[作者：Behari, J; Yeh, TH; Krauland, L; Otruba, W; Cieply, B; Hauth, B; Apte, U; Wu, T; Evans, R; Monga, SPS,期刊：American Journal of Pathology, 页码：744-753 , 文章类型： Article，,卷期：2010年176-2]
- Although the role of Wnt/beta-catenin signaling in liver growth and development is well established, its contribution in non-neoplastic hepatic pathologies has not been investigated. Here, we examine the role of beta-cat...
- Plasmacytoid Dendritic Cells Control Lung Inflammation and Monocyte Recruitment in Indirect Acute Lung Injury in Mice
[作者：Venet, F; Huang, X; Chung, CS; Chen, YP; Ayala, A,期刊：American Journal of Pathology, 页码：764-773 , 文章类型： Article，,卷期：2010年176-2]
- Indirect acute lung injury (ALI, not caused by a direct insult to the lung) represents the first organ dysfunction in trauma patients, with nonpulmonary sepsis being the most common cause of indirect ALI. Dendritic cells...
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