- Uncovering pathways in DNA oligonucleotide hybridization via transition state analysis
[作者:Sambriski, EJ; Schwartz, DC; de Pablo, JJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18125-18130 , 文章类型: Article,,卷期:2009年106-43]
- DNA hybridization plays a central role in biology and, increasingly, in materials science. Yet, there is no precedent for examining the pathways by which specific single-stranded DNA sequences interact to assemble into a...
- Kinetics of hyperpolarized C-13(1)-pyruvate transport and metabolism in living human breast cancer cells
[作者:Harris, T; Eliyahu, G; Frydman, L; Degani, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18131-18136 , 文章类型: Article,,卷期:2009年106-43]
- Metabolic fluxes can serve as specific biomarkers for detecting malignant transformations, tumor progression, and response to microenvironmental changes and treatment procedures. We present noninvasive hyperpolarized C-1...
- Glycans on influenza hemagglutinin affect receptor binding and immune response
[作者:Wang, CC; Chen, JR; Tseng, YC; Hsu, CH; Hung, YF; Chen, SW; Chen, CM; Khoo, KH; Cheng, TJ; Cheng, YSE; Jan, JT; Wu, CY; Ma, C; Wong, CH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18137-18142 , 文章类型: Article,,卷期:2009年106-43]
- Recent cases of avian influenza H5N1 and the swine-origin 2009 H1N1 have caused a great concern that a global disaster like the 1918 influenza pandemic may occur again. Viral transmission begins with a critical interacti...
- Podosomes are present in a postsynaptic apparatus and participate in its maturation
[作者:Proszynski, TJ; Gingras, J; Valdez, G; Krzewski, K; Sanes, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18373-18378 , 文章类型: Article,,卷期:2009年106-43]
- A critical step in synapse formation is the clustering of neurotransmitter receptors in the postsynaptic membrane, directly opposite the nerve terminal. At the neuromuscular junction, a widely studied model synapse, acet...
- Gray and white matter changes associated with tool-use learning in macaque monkeys
[作者:Quallo, MM; Price, CJ; Ueno, K; Asamizuya, T; Cheng, K; Lemon, RN; Iriki, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18379-18384 , 文章类型: Article,,卷期:2009年106-43]
- We used noninvasive MRI and voxel-based morphometry (VBM) to detect changes in brain structure in three adult Japanese macaques trained to use a rake to retrieve food rewards. Monkeys, who were naive to any previous tool...
- Tracking lineages of single cells in lines using a microfluidic device
[作者:Rowat, AC; Bird, JC; Agresti, JJ; Rando, OJ; Weitz, DA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18149-18154 , 文章类型: Article,,卷期:2009年106-43]
- Cells within a genetically identical population exhibit phenotypic variation that in some cases can persist across multiple generations. However, information about the temporal variation and familial dependence of protei...
- An independent evaluation of the Younger Dryas extraterrestrial impact hypothesis
[作者:Surovell, TA; Holliday, VT; Gingerich, JAM; Ketron, C; Haynes, CV; Hilman, I; Wagner, DP; Johnson, E; Claeys, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18155-18158 , 文章类型: Article,,卷期:2009年106-43]
- Based on elevated concentrations of a set of "impact markers'' at the onset of the Younger Dryas stadial from sedimentary contexts across North America, Firestone, Kennett, West, and others have argued that 12.9 ka the E...
- Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action
[作者:Aldrich, JV; Patkar, KA; McLaughlin, JP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18396-18401 , 文章类型: Article,,卷期:2009年106-43]
- The cyclic peptide zyklophin {[N-benzylTyr(1), cyclo(D-Asp(5), Dap(8))-dynorphin A-(1-11)NH2, Patkar KA, et al. (2005) J Med Chem 48: 4500-4503} is a selective peptide kappa opioid receptor (KOR) antagonist that shows ac...
- Site-specific recombination for the modification of transgenic strains of the Mediterranean fruit fly Ceratitis capitata
[作者:Schetelig, MF; Scolari, F; Handler, AM; Kittelmann, S; Gasperi, G; Wimmer, EA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18171-18176 , 文章类型: Article,,卷期:2009年106-43]
- Insect transgenesis is mainly based on the random genomic integration of DNA fragments embedded into non-autonomous transposable elements. Once a random insertion into a specific location of the genome has been identifie...
- alpha-Actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)
[作者:Lu, L; Timofeyev, V; Li, N; Rafizadeh, S; Singapuri, A; Harris, TR; Chiamvimonvat, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18402-18407 , 文章类型: Article,,卷期:2009年106-43]
- The importance of proper ion channel trafficking is underpinned by a number of channel- linked genetic diseases whose defect is associated with failure to reach the cell surface. Conceptually, it is reasonable to suggest...
- Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
[作者:Jensen, LDE; Cao, R; Hedlund, EM; Soll, I; Lundberg, JO; Hauptmann, G; Steffensen, JF; Cao, YH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18408-18413 , 文章类型: Article,,卷期:2009年106-43]
- The blood and lymphatic vasculatures are structurally and functionally coupled in controlling tissue perfusion, extracellular interstitial fluids, and immune surveillance. Little is known, however, about the molecular me...
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