- Post-Pleistocene radiation of the pea aphid complex revealed by rapidly evolving endosymbionts
[作者:Peccoud, J; Simon, JC; McLaughlin, HJ; Moran, NA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16315-16320 , 文章类型: Article,,卷期:2009年106-38]
- Adaptation to different resources has the potential to cause rapid species diversification, but few studies have been able to quantify the time scale of recent adaptive radiations. The pea aphid, Acyrthosiphon pisum, a m...
- Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes
[作者:Ravi, V; Lam, K; Tay, BH; Tay, A; Brenner, S; Venkatesh, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16327-16332 , 文章类型: Article,,卷期:2009年106-38]
- We have sequenced and analyzed Hox gene clusters from elephant shark, a holocephalian cartilaginous fish. Elephant shark possesses 4 Hox clusters with 45 Hox genes that include orthologs for a higher number of ancient gn...
- Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF kappa B
[作者:Lu, T; Jackson, MW; Singhi, AD; Kandel, ES; Yang, MJ; Zhang, Y; Gudkov, AV; Stark, GR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16339-16344 , 文章类型: Article,,卷期:2009年106-38]
- We describe a highly efficient use of lentiviral validation-based insertional mutagenesis (VBIM) to generate large populations of mammalian cells in which a strong promoter is inserted into many different genomic loci, c...
- Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes
[作者:Patrick, MS; Oda, H; Hayakawa, K; Sato, Y; Eshima, K; Kirikae, T; Iemura, S; Shirai, M; Abe, T; Natsume, T; Sasazuki, T; Suzuki, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16345-16350 , 文章类型: Article,,卷期:2009年106-38]
- T cells develop in the thymus through positive and negative selection, which are responsible for shaping the T cell receptor (TCR) repertoire. To elucidate the molecular mechanisms involved in selection remains an area o...
- XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
[作者:Schlaberg, R; Choe, DJ; Brown, KR; Thaker, HM; Singh, IR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16351-16356 , 文章类型: Article,,卷期:2009年106-38]
- Xenotropic murine leukemia virus-related virus (XMRV) was recently discovered in human prostate cancers and is the first gammaretrovirus known to infect humans. While gammaretroviruses have wellcharacterized oncogenic ef...
- Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
[作者:Lee, JW; Fang, XH; Gupta, N; Serikov, V; Matthay, MA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16357-16362 , 文章类型: Article,,卷期:2009年106-38]
- Recent studies have suggested that bone marrow-derived multipotent mesenchymal stem cells (MSCs) may have therapeutic applications in multiple clinical disorders including myocardial infarction, diabetes, sepsis, and hep...
- Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
[作者:Brantly, ML; Chulay, JD; Wang, LL; Mueller, C; Humphries, M; Spencer, LT; Rouhani, F; Conlon, TJ; Calcedo, R; Betts, MR; Spencer, C; Byrne, BJ; Wilson, JM; Flotte, TR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16363-16368 , 文章类型: Article,,卷期:2009年106-38]
- Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, dose-escalation clinical trial of a recombinant adeno-associated virus (rAAV) vector expressing...
- aPKC lambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
[作者:Ishiguro, H; Akimoto, K; Nagashima, Y; Kojima, Y; Sasaki, T; Ishiguro-Imagawa, Y; Nakaigawa, N; Ohno, S; Kubota, Y; Uemura, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16369-16374 , 文章类型: Article,,卷期:2009年106-38]
- Understanding the mechanism by which hormone refractory prostate cancer (HRPC) develops remains a major issue. Alterations in HRPC include androgen receptor (AR) changes. In addition, the AR is activated by cytokines suc...
- Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [F-18]-labeled isatin sulfonamide
[作者:Nguyen, QD; Smith, G; Glaser, M; Perumal, M; Arstad, E; Aboagye, EO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16375-16380 , 文章类型: Article,,卷期:2009年106-38]
- Of the molecular biochemical alterations that occur during apoptosis, activation of caspases, notably caspase-3, is probably the most attractive for developing specific in vivo molecular imaging probes. We recently desig...
- Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential
[作者:Andrechek, ER; Cardiff, RD; Chang, JT; Gatza, ML; Acharya, CR; Potti, A; Nevins, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16387-16392 , 文章类型: Article,,卷期:2009年106-38]
- Human cancers result from a complex series of genetic alterations, resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities ...
- Opportunistic pathogens enriched in showerhead biofilms
[作者:Feazel, LM; Baumgartner, LK; Peterson, KL; Frank, DN; Harris, JK; Pace, NR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16393-16398 , 文章类型: Article,,卷期:2009年106-38]
- The environments we humans encounter daily are sources of exposure to diverse microbial communities, some of potential concern to human health. In this study, we used culture-independent technology to investigate the mic...
- Spatiotemporal patterns and transcription kinetics of induced RNA in single bacterial cells
[作者:Valencia-Burton, M; Shah, A; Sutin, J; Borogovac, A; McCullough, RM; Cantor, CR; Meller, A; Broude, NE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16399-16404 , 文章类型: Article,,卷期:2009年106-38]
- Bacteria have a complex internal organization with specific localization of many proteins and DNA, which dynamically move during the cell cycle and in response to changing environmental stimuli. Much less is known, howev...
- A genome-wide genetic screen for host factors required for hepatitis C virus propagation
[作者:Li, QS; Brass, AL; Ng, A; Hu, ZY; Xavier, RJ; Liang, TJ; Elledge, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16410-16415 , 文章类型: Article,,卷期:2009年106-38]
- Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading indication for liver transplantation. Current therapy fails in many instances and is associated with significant side effects. H...
- Community proteogenomics reveals insights into the physiology of phyllosphere bacteria
[作者:Delmotte, N; Knief, C; Chaffron, S; Innerebner, G; Roschitzki, B; Schlapbach, R; von Mering, C; Vorholt, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16428-16433 , 文章类型: Article,,卷期:2009年106-38]
- Aerial plant surfaces represent the largest biological interface on Earth and provide essential services as sites of carbon dioxide fixation, molecular oxygen release, and primary biomass production. Rather than existing...
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