- Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
[作者:Jackson, CJ; Foo, JL; Tokuriki, N; Afriat, L; Carr, PD; Kim, HK; Schenk, G; Tawfik, DS; Ollis, DL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21631-21636 , 文章类型: Article,,卷期:2009年106-51]
- To efficiently catalyze a chemical reaction, enzymes are required to maintain fast rates for formation of the Michaelis complex, the chemical reaction and product release. These distinct demands could be satisfied via fl...
- Site-directed spin labeling of a genetically encoded unnatural amino acid
[作者:Fleissner, MR; Brustad, EM; Kalai, T; Altenbach, C; Cascio, D; Peters, FB; Hideg, K; Schultz, PG; Hubbell, WL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21637-21642 , 文章类型: Article,,卷期:2009年106-51]
- The traditional site-directed spin labeling (SDSL) method, which utilizes cysteine residues and sulfhydryl-reactive nitroxide reagents, can be challenging for proteins that contain functionally important native cysteine ...
- A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin
[作者:McLaughlin, JE; Bin-Umer, MA; Tortora, A; Mendez, N; McCormick, S; Tumer, NE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21883-21888 , 文章类型: Article,,卷期:2009年106-51]
- Trichothecene mycotoxins synthesized by Fusarium species are potent inhibitors of eukaryotic translation. They are encountered in both the environment and in food, posing a threat to human and animal health. They have di...
- An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons
[作者:Hao, J; Wang, XD; Dan, Y; Poo, MM; Zhang, XH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21906-21911 , 文章类型: Article,,卷期:2009年106-51]
- Dendritic integration of excitatory and inhibitory inputs is critical for neuronal computation, but the underlying rules remain to be elucidated. Based on realistic modeling and experiments in rat hippocampal slices, we ...
- Deletion of phospholipase C beta 4 in thalamocortical relay nucleus leads to absence seizures
[作者:Cheong, E; Zheng, Y; Lee, K; Lee, J; Kim, S; Sanati, M; Lee, S; Kim, YS; Shin, HS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21912-21917 , 文章类型: Article,,卷期:2009年106-51]
- Absence seizures are characterized by cortical spike-wave discharges (SWDs) on electroencephalography, often accompanied by a shift in the firing pattern of thalamocortical (TC) neurons from tonic to burst firing driven ...
- Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning
[作者:Li, YT; Li, HH; Liu, X; Bao, GB; Tao, YZ; Wu, ZY; Xia, P; Wu, CF; Li, BM; Ma, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21918-21923 , 文章类型: Article,,卷期:2009年106-51]
- beta-arrestins, key regulators of receptor signaling, are highly expressed in the central nervous system, but their roles in brain physiology are largely unknown. Here we show that beta-arrestin-2 is critically involved ...
- The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation
[作者:Tong, XM; Zhao, FP; Mancuso, A; Gruber, JJ; Thompson, CB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21660-21665 , 文章类型: Article,,卷期:2009年106-51]
- Tumor cells are metabolically reprogrammed to fuel cell proliferation. Most transformed cells take up high levels of glucose and produce ATP through aerobic glycolysis. In cells exhibiting aerobic glycolysis, a significa...
- Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish
[作者:Appelbaum, L; Wang, GX; Maro, GS; Mori, R; Tovin, A; Marin, W; Yokogawa, T; Kawakami, K; Smith, SJ; Gothilf, Y; Mignot, E; Mourrain, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21942-21947 , 文章类型: Article,,卷期:2009年106-51]
- In mammals, hypocretin/orexin (HCRT) neuropeptides are important sleep-wake regulators and HCRT deficiency causes narcolepsy. In addition to fragmented wakefulness, narcoleptic mammals also display sleep fragmentation, a...
|