- Cloning of the Human GLI2 Promoter TRANSCRIPTIONAL ACTIVATION BY TRANSFORMING GROWTH FACTOR-beta VIA SMAD3/beta-CATENIN COOPERATION
[作者:Dennler, S; Andre, J; Verrecchia, F; Mauviel, A,期刊:Journal of Biological Chemistry, 页码:31523-31531 , 文章类型: Article,,卷期:2009年284-46]
- GLI2 (GLI-Kruppel family member 2), a zinc finger transcription factor that mediates Hedgehog signaling, is implicated in the progression of an ever-growing number of human malignancies, including prostate and pancreatic...
- Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases
[作者:Gutsche, M; Sobotta, MC; Wabnitz, GH; Ballikaya, S; Meyer, AJ; Samstag, Y; Dick, TP,期刊:Journal of Biological Chemistry, 页码:31532-31540 , 文章类型: Article,,卷期:2009年284-46]
- H2O2 acts as a signaling molecule by oxidizing critical thiol groups on redox-regulated target proteins. To explain the efficiency and selectivity of H2O2-based signaling, it has been proposed that oxidation of target pr...
- Ligand and Substrate Migration in Human Indoleamine 2,3-Dioxygenase
[作者:Nickel, E; Nienhaus, K; Lu, CY; Yeh, SR; Nienhaus, GU,期刊:Journal of Biological Chemistry, 页码:31548-31554 , 文章类型: Article,,卷期:2009年284-46]
- Human indoleamine 2,3-dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L-Trp and other indoleamine derivatives. Using Fourier transform infrared and optical absorption spectroscopy, we ...
- Functional Whole-genome Analysis Identifies Polo-like Kinase 2 and Poliovirus Receptor as Essential for Neuronal Differentiation Upstream of the Negative Regulator alpha B-crystallin
[作者:Draghetti, C; Salvat, C; Zanoguera, F; Curchod, ML; Vignaud, C; Peixoto, H; Di Cara, A; Fischer, D; Dhanabal, M; Andreas, G; Abderrahim, H; Rommel, C; Camps, M,期刊:Journal of Biological Chemistry, 页码:32053-32065 , 文章类型: Article,,卷期:2009年284-46]
- This study aimed at identifying transcriptional changes associated to neuronal differentiation induced by six distinct stimuli using whole-genome microarray hybridization analysis. Bioinformatics analyses revealed the cl...
- Hypoxia-inducible Factor-1-mediated Regulation of Semaphorin 4D Affects Tumor Growth and Vascularity
[作者:Sun, QM; Zhou, H; Binmadi, NO; Basile, JR,期刊:Journal of Biological Chemistry, 页码:32066-32074 , 文章类型: Article,,卷期:2009年284-46]
- Tumor progression and metastasis depend on the ability of cancer cells to initiate angiogenesis to ensure delivery of oxygen, nutrients, and growth factors to tumor cells and provide access to the systemic circulation. H...
- Nucleotide Binding by Lhs1p Is Essential for Its Nucleotide Exchange Activity and for Function in Vivo
[作者:de Keyzer, J; Steel, GJ; Hale, SJ; Humphries, D; Stirling, CJ,期刊:Journal of Biological Chemistry, 页码:31564-31571 , 文章类型: Article,,卷期:2009年284-46]
- Protein translocation and folding in the endoplasmic reticulum of Saccharomyces cerevisiae involves two distinct Hsp70 chaperones, Lhs1p and Kar2p. Both proteins have the characteristic domain structure of the Hsp70 fami...
- The Ig Domain Protein CD9P-1 Down-regulates CD81 Ability to Support Plasmodium yoelii Infection
[作者:Charrin, S; Yalaoui, S; Bartosch, B; Cocquerel, L; Franetich, JF; Boucheix, C; Mazier, D; Rubinstein, E; Silvie, O,期刊:Journal of Biological Chemistry, 页码:31572-31578 , 文章类型: Article,,卷期:2009年284-46]
- Invasion of hepatocytes by Plasmodium sporozoites is a prerequisite for establishment of a malaria natural infection. The molecular mechanisms underlying sporozoite invasion are largely unknown. We have previously report...
- X-ray Crystal Structure of Michaelis Complex of Aldoxime Dehydratase
[作者:Sawai, H; Sugimoto, H; Kato, Y; Asano, Y; Shiro, Y; Aono, S,期刊:Journal of Biological Chemistry, 页码:32089-32096 , 文章类型: Article,,卷期:2009年284-46]
- Aldoxime dehydratase (Oxd) catalyzes the dehydration of aldoximes (R-CH=N-OH) to their corresponding nitrile (R-C N). Oxd is a heme-containing enzyme that catalyzes the dehydration reaction as its physiological function...
- Spatiotemporal Regulation of Early Lipolytic Signaling in Adipocytes
[作者:Martin, S; Okano, S; Kistler, C; Fernandez-Rojo, MA; Hill, MM; Parton, RG,期刊:Journal of Biological Chemistry, 页码:32097-32107 , 文章类型: Article,,卷期:2009年284-46]
- Hormone-sensitive lipase (HSL) is a key enzyme regulating the acute activation of lipolysis. HSL functionality is controlled by multiple phosphorylation events, which regulate its association with the surface of lipid dr...
- Targeting Human Epidermal Growth Factor Receptor Signaling with the Neuregulin's Heparin-binding Domain
[作者:Ma, ZZ; Li, QF; An, HQ; Pankonin, MS; Wang, JJ; Loeb, JA,期刊:Journal of Biological Chemistry, 页码:32108-32115 , 文章类型: Article,,卷期:2009年284-46]
- A major limitation in biopharmaceutical development is selectively targeting drugs to diseased tissues. Growth factors and viruses have solved this problem by targeting tissue-specific cell-surface heparan sulfates. Neur...
- Active NF-E2-related Factor (Nrf2) Contributes to Keep Endothelial NO Synthase (eNOS) in the Coupled State ROLE OF REACTIVE OXYGEN SPECIES (ROS), eNOS, AND HEME OXYGENASE (HO-1) LEVELS
[作者:Heiss, EH; Schachner, D; Werner, ER; Dirsch, VM,期刊:Journal of Biological Chemistry, 页码:31579-31586 , 文章类型: Article,,卷期:2009年284-46]
- The aim of our study was to examine in detail the impact of NF-E2-related factor (Nrf2) activation on endothelial cell function with focus on redox homeostasis and the endothelial nitric oxide synthase (eNOS) system. We ...
- The Intrinsically Disordered N-terminal Domain of Thymidylate Synthase Targets the Enzyme to the Ubiquitin-independent Proteasomal Degradation Pathway
[作者:Pena, MMO; Melo, SP; Xing, YY; White, K; Barbour, KW; Berger, FG,期刊:Journal of Biological Chemistry, 页码:31597-31607 , 文章类型: Article,,卷期:2009年284-46]
- The ubiquitin-independent proteasomal degradation pathway is increasingly being recognized as important in regulation of protein turnover in eukaryotic cells. One substrate of this pathway is the pyrimidine biosynthetic ...
- The HECT Domain of the Ubiquitin Ligase Rsp5 Contributes to Substrate Recognition
[作者:Lee, JRE; Oestreich, AJ; Payne, JA; Gunawan, MS; Norgan, AP; Katzmann, DJ,期刊:Journal of Biological Chemistry, 页码:32126-32137 , 文章类型: Article,,卷期:2009年284-46]
- Ubiquitin modification of endosomal membrane proteins is a signal for active inclusion into the Multivesicular Body (MVB) pathway, resulting in lysosomal degradation. However, the endosome represents a dynamic site of pr...
- Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells
[作者:Wang, CH; Xin, XB; Xiang, RH; Ramos, FJ; Liu, ML; Lee, HJ; Chen, HZ; Mao, XM; Kikani, CK; Liu, F; Dong, LQ,期刊:Journal of Biological Chemistry, 页码:31608-31615 , 文章类型: Article,,卷期:2009年284-46]
- APPL1 is a newly identified adiponectin receptor-binding protein that positively mediates adiponectin signaling in cells. Here we report that APPL2, an isoform of APPL1 that forms a dimer with APPL1, can interacts with b...
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