- The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor
[作者:Scheinberg, P; Melenhorst, JJ; Brenchley, JM; Hill, BJ; Hensel, NF; Chattopadhyay, PK; Roederer, M; Picker, LJ; Price, DA; Barrett, AJ; Douek, DC,期刊:Blood, 页码:5071-5080 , 文章类型: Article,,卷期:2009年114-24]
- The successful reconstitution of adaptive immunity to human cytomegalovirus (CMV) in hematopoietic stem cell transplantation (HSCT) recipients is central to the reduction of viral reactivation-related morbidity and morta...
- An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression
[作者:Trinidad, EM; Ballesteros, M; Zuloaga, J; Zapata, A; Alonso-Colmenar, LM,期刊:Blood, 页码:5081-5090 , 文章类型: Article,,卷期:2009年114-24]
- Chronic lymphocytic leukemia (CLL) cell migration into lymphoid tissues is an important aspect of the pathobiology of this disease. Here, we investigated the role of ephrin-A4 (EFNA4) in the transendothelial migration (T...
- Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation
[作者:Stratman, AN; Malotte, KM; Mahan, RD; Davis, MJ; Davis, GE,期刊:Blood, 页码:5091-5101 , 文章类型: Article,,卷期:2009年114-24]
- We show that endothelial cell (EC)-generated vascular guidance tunnels (ie, matrix spaces created during tube formation) serve as conduits for the recruitment and motility of pericytes along EC ablumenal surfaces to faci...
- Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage
[作者:Turner, NA; Nolasco, L; Ruggeri, ZM; Moake, JL,期刊:Blood, 页码:5102-5111 , 文章类型: Article,,卷期:2009年114-24]
- Human umbilical vein endothelial cell (HUVEC)-released ADAMTS-13 ( a disintegrin and metalloprotease with thrombospondin repeats) and HUVEC-secreted von Willebrand factor (VWF) strings were investigated under static cond...
- The role of B cells in the pathogenesis of graft-versus-host disease
[作者:Shimabukuro-Vornhagen, A; Hallek, MJ; Storb, RF; von Bergwelt-Baildon, MS,期刊:Blood, 页码:4919-4927 , 文章类型: Review,,卷期:2009年114-24]
- Allogeneic hematopoietic stem cell transplantation is an established treatment modality for malignant and nonmalignant hematologic diseases. Acute and chronic graft-versus-host diseases (GVHDs) are a major cause of morbi...
- Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study
[作者:Tsai, HT; Caporaso, NE; Kyle, RA; Katzmann, JA; Dispenzieri, A; Hayes, RB; Marti, GE; Albitar, M; Ghia, P; Rajkumar, SV; Landgren, O,期刊:Blood, 页码:4928-4932 , 文章类型: Article,,卷期:2009年114-24]
- Immune-related deficiencies are well-known complications of chronic lymphocytic leukemia (CLL). Although recent data indicate that almost all CLL patients are preceded by a monoclonal B-cell lymphocytosis precursor state...
- Nilotinib for the frontline treatment of Ph+ chronic myeloid leukemia
[作者:Rosti, G; Palandri, F; Castagnetti, F; Breccia, M; Levato, L; Gugliotta, G; Capucci, A; Cedrone, M; Fava, C; Intermesoli, T; Cambrin, GR; Stagno, F; Tiribelli, M; Amabile, M; Luatti, S; Poerio, A; Soverini, S; Testoni, N; Martinelli, G; Alimena, G; Pane, F; Saglio, G; Baccarani, M,期刊:Blood, 页码:4933-4938 , 文章类型: Article,,卷期:2009年114-24]
- Nilotinib has a higher binding affinity and selectivity for BCR-ABL with respect to imatinib and is an effective treatment of chronic myeloid leukemia (CML) after imatinib failure. In a phase 2 study, 73 early chronic-ph...
- Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WP
[作者:Testoni, N; Marzocchi, G; Luatti, S; Amabile, M; Baldazzi, C; Stacchini, M; Nanni, M; Rege-Cambrin, G; Giugliano, E; Giussani, U; Abruzzese, E; Kerim, S; Grimoldi, MG; Gozzetti, A; Crescenzi, B; Carcassi, C; Bernasconi, P; Cuneo, A; Albano, F; Fugazza, G; Zaccaria, A; Martinelli, G; Pane, F; Rosti, G; Baccarani, M,期刊:Blood, 页码:4939-4943 , 文章类型: Article,,卷期:2009年114-24]
- In chronic myeloid leukemia, different methods are available to monitor the response to therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization (I-FISH), and real-time quantitative polym...
- Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations
[作者:Muller, MC; Cortes, JE; Kim, DW; Druker, BJ; Erben, P; Pasquini, R; Branford, S; Hughes, TP; Radich, JP; Ploughman, L; Mukhopadhyay, J; Hochhaus, A,期刊:Blood, 页码:4944-4953 , 文章类型: Article,,卷期:2009年114-24]
- Dasatinib is a BCR-ABL inhibitor with 325-fold higher potency than imatinib against unmutated BCR-ABL in vitro. Imatinib failure is commonly caused by BCR-ABL mutations. Here, dasatinib efficacy was analyzed in patients ...
- Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition
[作者:de Larrea, CF; Cibeira, MT; Elena, M; Arostegui, JI; Rosino, L; Rovira, M; Filella, X; Yague, J; Blade, J,期刊:Blood, 页码:4954-4956 , 文章类型: Article,,卷期:2009年114-24]
- The prevalence of an abnormal serum free light chain (FLC) ratio in 34 patients with multiple myeloma in complete response (CR) after hematopoietic stem cell transplantation was studied. Fourteen of 34 patients (41.2%) s...
- Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens
[作者:Vrana, JA; Gamez, JD; Madden, BJ; Theis, JD; Bergen, HR; Dogan, A,期刊:Blood, 页码:4957-4959 , 文章类型: Article,,卷期:2009年114-24]
- The clinical management of amyloidosis is based on the treatment of the underlying etiology, and accurate identification of the protein causing the amyloidosis is of paramount importance. Current methods used for typing ...
- Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
[作者:Duber, S; Hafner, M; Krey, M; Lienenklaus, S; Roy, B; Hobeika, E; Reth, M; Buch, T; Waisman, A; Kretschmer, K; Weiss, S,期刊:Blood, 页码:4960-4967 , 文章类型: Article,,卷期:2009年114-24]
- To study B-cell development from bone marrow (BM), we generated recombination-activating gene 1 (Rag1)-targeted mice lacking mature lymphocytes. B-cell development can be induced in such mice by B cell-specific restorati...
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