- Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate
[作者:Meyer, M; Dohmen, C; Philipp, A; Kiener, D; Maiwald, G; Scheu, C; Ogris, M; Wagner, E,期刊:Molecular Pharmaceutics, 页码:752-762 , 文章类型: Article,,卷期:2009年6-3]
- Extracellular stability of electrostatically formed siRNA polyplexes is a significant concern in the delivery process. To overcome the risk of polyplex dissociation in the extracellular environment, siRNA was covalently ...
- Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted Tc-99m-Radioimaging Agents
[作者:Kularatne, SA; Zhou, ZG; Yang, J; Post, CB; Low, PS,期刊:Molecular Pharmaceutics, 页码:790-800 , 文章类型: Article,,卷期:2009年6-3]
- The high mortality and financial burden associated with prostate cancer can be partly attributed to a lack of sensitive screening methods for detection and staging of the disease. Guided by in silico docking studies usin...
- Antitumor Therapy Mediated by 5-Fluorocytosine and a Recombinant Fusion Protein Containing TSG-6 Hyaluronan Binding Domain and Yeast Cytosine Deaminase
[作者:Park, JI; Cao, LM; Platt, VM; Huang, ZH; Stull, RA; Dy, EE; Sperinde, JJ; Yokoyama, JS; Szoka, FC,期刊:Molecular Pharmaceutics, 页码:801-812 , 文章类型: Article,,卷期:2009年6-3]
- Matrix attachment therapy (MAT) is an enzyme prodrug strategy that targets hyaluronan in the tumor extracellular matrix to deliver a prodrug converting enzyme near the tumor cells. A recombinant fusion protein containing...
- Kahalalide F, an Antitumor Depsipeptide in Clinical Trials, and Its Analogues as Effective Antileishmanial Agents
[作者:Cruz, LJ; Luque-Ortega, JR; Rivas, L; Albericio, F,期刊:Molecular Pharmaceutics, 页码:813-824 , 文章类型: Article,,卷期:2009年6-3]
- Leishmaniasis is a human parasitic disease caused by infection by the protozoan Leishmania spp. Chemotherapy is currently the only treatment available, but its efficacy is increasingly challenged by the rising incidence ...
- Endocytosis and Membrane Potential Are Required for HeLa Cell Uptake of RI-CKTat9, a Retro-Inverso Tat Cell Penetrating Peptide
[作者:Zhang, XP; Jin, YJ; Pllummer, MR; Pooyan, S; Gunaseelan, S; Sinko, PJ,期刊:Molecular Pharmaceutics, 页码:836-848 , 文章类型: Article,,卷期:2009年6-3]
- Cell-penetrating peptides (CPPs) can enter many types of cells and have become useful tools for introducing a variety of cargo such as exogenous peptides, proteins, and nucleic acids into cultured cells in vitro. Tat CPP...
- Dry Hybrid Lipid-Silica Microcapsules Engineered from Submicron Lipid Droplets and Nanoparticles as a Novel Delivery System for Poorly Soluble Drugs
[作者:Simovic, S; Heard, P; Hui, H; Song, YM; Peddie, F; Davey, AK; Lewis, A; Rades, T; Prestidge, CA,期刊:Molecular Pharmaceutics, 页码:861-872 , 文章类型: Article,,卷期:2009年6-3]
- We report on the fabrication and characterization of dry hybrid lipid-silica nanoparticle based microcapsules with an internal porous matrix structure for encapsulation of poorly soluble drugs, and their delivery propert...
- Melanoma Activation of 3-O-(3,4,5-Trimethoxybenzoyl)-(-)-Epicatechin to a Potent Irreversible Inhibitor of Dihydrofolate Reductase
[作者:Sanchez-del-Campo, L; Tarraga, A; Montenegro, MF; Cabezas-Herrera, J; Rodriguez-Lopez, JN,期刊:Molecular Pharmaceutics, 页码:883-894 , 文章类型: Article,,卷期:2009年6-3]
- Human melanoma is a significant clinical problem because it is resistant to treatment by most chemotherapeutic agents, including antifolates. It is therefore a desirable goal to develop a second generation of low-toxicit...
- Development of a Nitric Oxide-Releasing Analogue of the Muscle Relaxant Guaifenesin for Skeletal Muscle Satellite Cell Myogenesis
[作者:Wang, GQ; Burczynski, FJ; Hasinoff, BB; Zhang, KD; Lu, QL; Anderson, JE,期刊:Molecular Pharmaceutics, 页码:895-904 , 文章类型: Article,,卷期:2009年6-3]
- Nitric oxide (NO) mediates activation of satellite precursor cells to enter the cell cycle. This provides new precursor cells for skeletal muscle growth and muscle repair from injury or disease. Targeting a new drug that...
- Dual-Targeting Topotecan Liposomes Modified with Tamoxifen and Wheat Germ Agglutinin Significantly Improve Drug Transport across the Blood-Brain Barrier and Survival of Brain Tumor-Bearing Animals
[作者:Du, J; Lu, WL; Ying, X; Liu, Y; Du, P; Tian, W; Men, Y; Guo, J; Zhang, Y; Li, RJ; Zhou, J; Lou, JN; Wang, JC; Zhang, X; Zhang, Q,期刊:Molecular Pharmaceutics, 页码:905-917 , 文章类型: Article,,卷期:2009年6-3]
- Chemotherapy of brain tumors remains a big challenge owing to the low drug transport across the blood-brain barrier (BBB), multidrug resistance (MDR), and poor penetration into the tumor tissue. We developed a novel dual...
- Single Subcutaneous Administration of RGDK-Lipopeptide:rhPDGF-B Gene Complex Heals Wounds in Streptozotocin-Induced Diabetic Rats
[作者:Bhattacharyya, J; Mondal, G; Madhusudana, K; Agawane, SB; Ramakrishna, S; Gangireddy, SR; Madhavi, RD; Reddy, PK; Konda, VR; Rao, SR; Udaykumar, P; Chaudhuri, A,期刊:Molecular Pharmaceutics, 页码:918-927 , 文章类型: Article,,卷期:2009年6-3]
- Development of effective therapeutics for chronic wounds remains a formidable clinical challenge. Deficiency of growth factors is of paramount importance among the multitude of factors contributing to the pathogenesis of...
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