- A Randomly Integrated Transgenic H19 Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ Cells
[作者:Matsuzaki, H; Okamura, E; Shimotsuma, M; Fukamizu, A; Tanimoto, K,期刊:Molecular and Cellular Biology, 页码:4595-4603 , 文章类型: Article,,卷期:2009年29-17]
- The imprinted expression of the mouse Igf2/H19 locus is governed by the differential methylation of the imprinting control region (ICR), which is established initially in germ cells and subsequently maintained in somatic...
- A Noncanonical Bromodomain in the AAA ATPase Protein Yta7 Directs Chromosomal Positioning and Barrier Chromatin Activity
[作者:Gradolatto, A; Smart, SK; Byrum, S; Blair, LP; Rogers, RS; Kolar, EA; Lavender, H; Larson, SK; Aitchison, JD; Taverna, SD; Tackett, AJ,期刊:Molecular and Cellular Biology, 页码:4604-4611 , 文章类型: Article,,卷期:2009年29-17]
- Saccharomyces cerevisiae Yta7 is a barrier active protein that modulates transcriptional states at the silent mating locus, HMR. Additionally, Yta7 regulates histone gene transcription and has overlapping functions with ...
- Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc
[作者:Caldon, CE; Sergio, CM; Schutte, J; Boersma, MN; Sutherland, RL; Carroll, JS; Musgrove, EA,期刊:Molecular and Cellular Biology, 页码:4623-4639 , 文章类型: Article,,卷期:2009年29-17]
- During estrogen-induced proliferation, c-Myc and cyclin D1 initiate independent pathways that activate cyclin E1-Cdk2 by sequestration and/or downregulation of the CDK inhibitor p21(Waf1/Cip1), without significant increa...
- Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix
[作者:Kalinina, J; Byron, SA; Makarenkova, HP; Olsen, SK; Eliseenkova, AV; Larochelle, WJ; Dhanabal, M; Blais, S; Ornitz, DM; Day, LA; Neubert, TA; Pollock, PM; Mohammadi, M,期刊:Molecular and Cellular Biology, 页码:4663-4678 , 文章类型: Article,,卷期:2009年29-17]
- Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases, necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein, we demonstrate that FGF9 and FG...
- The mTORC2 Complex Regulates Terminal Differentiation of C2C12 Myoblasts
[作者:Shu, LL; Houghton, PJ,期刊:Molecular and Cellular Biology, 页码:4691-4700 , 文章类型: Article,,卷期:2009年29-17]
- Rapamycin, a selective inhibitor of mTORC1 signaling, blocks terminal myoblast differentiation. We found that downregulation of rictor, a component of the mTORC2 complex, but not downregulation of raptor, a component of ...
- The p107/E2F Pathway Regulates Fibroblast Growth Factor 2 Responsiveness in Neural Precursor Cells
[作者:McClellan, KA; Vanderluit, JL; Julian, LM; Andrusiak, MG; Dugal-Tessier, D; Park, DS; Slack, RS,期刊:Molecular and Cellular Biology, 页码:4701-4713 , 文章类型: Article,,卷期:2009年29-17]
- We have previously shown that p107, a member of the retinoblastoma (Rb) cell cycle regulatory family, has a unique function in regulating the pool of neural precursor cells. As the pool of progenitors is regulated by a l...
- C/EBP alpha and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor gamma Agonists
[作者:Vernochet, C; Peres, SB; Davis, KE; McDonald, ME; Qiang, L; Wang, H; Scherer, PE; Farmer, SR,期刊:Molecular and Cellular Biology, 页码:4714-4728 , 文章类型: Article,,卷期:2009年29-17]
- White adipose tissue (WAT) stores energy in the form of triglycerides, whereas brown tissue (BAT) expends energy, primarily by oxidizing lipids. WAT also secretes many cytokines and acute-phase proteins that contribute t...
- Interaction of FLASH with Arsenite Resistance Protein 2 Is Involved in Cell Cycle Progression at S Phase
[作者:Kiriyama, M; Kobayashi, Y; Saito, M; Ishikawa, F; Yonehara, S,期刊:Molecular and Cellular Biology, 页码:4729-4741 , 文章类型: Article,,卷期:2009年29-17]
- FLASH has been shown to be required for S phase progression and to interact with a nuclear protein, ataxia-telangiectasia locus (NPAT), a component of Cajal bodies in the nucleus and an activator of histone transcription...
- Developmental Control of CaV1.2 L-Type Calcium Channel Splicing by Fox Proteins
[作者:Tang, ZZ; Zheng, SK; Nikolic, J; Black, DL,期刊:Molecular and Cellular Biology, 页码:4757-4765 , 文章类型: Article,,卷期:2009年29-17]
- CaV1.2 voltage-gated calcium channels play critical roles in the control of membrane excitability, gene expression, and muscle contraction. These channels show diverse functional properties generated by alternative splic...
- Loss of GATA6 Leads to Nuclear Deformation and Aneuploidy in Ovarian Cancer
[作者:Capo-Chichi, CD; Cai, KQ; Testa, JR; Godwin, AK; Xu, XX,期刊:Molecular and Cellular Biology, 页码:4766-4777 , 文章类型: Article,,卷期:2009年29-17]
- A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The development...
- Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities
[作者:Moraga, I; Harari, D; Schreiber, G; Uze, G; Pellegrini, S,期刊:Molecular and Cellular Biology, 页码:4778-4787 , 文章类型: Article,,卷期:2009年29-17]
- Multiple type I interferons (IFN-alpha/beta) elicit Jak/Stat activation, rapid gene induction, and pleiotropic effects, such as differentiation, antiviral protection, and blocks in proliferation, which are dependent on t...
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