- Intracellular domains interactions and gated motions of I-KS potassium channel subunits
[作者：Haitin, Y; Wiener, R; Shaham, D; Peretz, A; Cohen, EBT; Shamgar, L; Pongs, O; Hirsch, JA; Attali, B,期刊：EMBO journal, 页码：1994-2005 , 文章类型： Article，,卷期：2009年28-14]
- Voltage-gated K+ channels co-assemble with auxiliary beta subunits to form macromolecular complexes. In heart, assembly of Kv7.1 pore-forming subunits with KCNE1 beta subunits generates the repolarizing K+ current I-KS. ...
- Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing
[作者：Laufman, O; Kedan, A; Hong, WJ; Lev, S,期刊：EMBO journal, 页码：2006-2017 , 文章类型： Article，,卷期：2009年28-14]
- The crucial roles of Sec1/Munc18 (SM)-like proteins in membrane fusion have been evidenced in genetic and biochemical studies. SM proteins interact directly with SNAREs and contribute to SNARE pairing by a yet unclear me...
- Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
[作者：Sierra, SS; Deshmukh, SD; Kalnitski, J; Kunzi, P; Wymann, MP; Golenbock, DT; Henneke, P,期刊：EMBO journal, 页码：2018-2027 , 文章类型： Article，,卷期：2009年28-14]
- The recognition of bacterial lipoproteins by toll-like receptor (TLR) 2 is pivotal for inflammation initiation and control in many bacterial infections. TLR2-dependent signalling is currently believed to essentially requ...
- TAK1 is an essential regulator of BMP signalling in cartilage
[作者：Shim, JH; Greenblatt, MB; Xie, M; Schneider, MD; Zou, WG; Zhai, B; Gygi, S; Glimcher, LH,期刊：EMBO journal, 页码：2028-2041 , 文章类型： Article，,卷期：2009年28-14]
- TGF beta activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo functi...
- Conformational changes in switch I of EF-G drive its directional cycling on and off the ribosome
[作者：Ticu, C; Nechifor, R; Nguyen, B; Desrosiers, M; Wilson, KS,期刊：EMBO journal, 页码：2053-2065 , 文章类型： Article，,卷期：2009年28-14]
- We have trapped elongation factor G (EF-G) from Escherichia coli in six, functionally defined states, representing intermediates in its unidirectional catalytic cycle, which couples GTP hydrolysis to tRNA-mRNA translocat...
- BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
[作者：Choi, E; Choe, H; Min, J; Choi, JY; Kim, J; Lee, H,期刊：EMBO journal, 页码：2077-2089 , 文章类型： Article，,卷期：2009年28-14]
- Regulation of BubR1 is central to the control of APC/C activity. We have found that BubR1 forms a complex with PCAF and is acetylated at lysine 250. Using mass spectrometry and acetylated BubR1-specific antibodies, we ha...
- MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response
[作者：Pothof, J; Verkaik, NS; van IJcken, W; Wiemer, EAC; Ta, VTB; van der Horst, GTJ; Jaspers, NGJ; van Gent, DC; Hoeijmakers, JHJ; Persengiev, SP,期刊：EMBO journal, 页码：2090-2099 , 文章类型： Article，,卷期：2009年28-14]
- DNA damage provokes DNA repair, cell-cycle regulation and apoptosis. This DNA-damage response encompasses gene-expression regulation at the transcriptional and post-translational levels. We show that cellular responses t...
- Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
[作者：Lee, EW; Lee, MS; Camus, S; Ghim, J; Yang, MR; Oh, W; Ha, NC; Lane, DP; Song, J,期刊：EMBO journal, 页码：2100-2113 , 文章类型： Article，,卷期：2009年28-14]
Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, ...
- Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner
[作者：Sasso, S; Okvist, M; Roderer, K; Gamper, M; Codoni, G; Krengel, U; Kast, P,期刊：EMBO journal, 页码：2128-2142 , 文章类型： Article，,卷期：2009年28-14]
- Chorismate mutase catalyzes a key step in the shikimate biosynthetic pathway towards phenylalanine and tyrosine. Curiously, the intracellular chorismate mutase of Mycobacterium tuberculosis (MtCM; Rv0948c) has poor activ...
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