- Interpreting a Low Resolution Map of Human U1 snRNP Using Anomalous Scatterers
[作者：Oubridge, C; Krummel, DAP; Leung, AKW; Li, J; Nagai, K,期刊：Structure, 页码：930-938 , 文章类型： Article，,卷期：2009年17-7]
- We recently determined the crystal structure of the functional core of human U1 snRNP, consisting of nine proteins and one RNA, based on a 5.5 angstrom resolution electron density map. At 5-7 angstrom resolution, helices...
- Structure and Function of an ADP-Ribose-Dependent Transcriptional Regulator of NAD Metabolism
[作者：Huang, N; De Ingeniis, J; Galeazzi, L; Mancini, C; Korostelev, YD; Rakhmaninova, AB; Gelfand, MS; Rodionov, DA; Raffaelli, N; Zhang, H,期刊：Structure, 页码：939-951 , 文章类型： Article，,卷期：2009年17-7]
- Besides its function as an essential redox cofactor, nicotinamide adenine dinucleotide (NAD) also serves as a consumable substrate for several reactions with broad impact on many cellular processes. NAD homeostasis appea...
- Mg2+-Assisted Catalysis by B. Stearothermophilus TrpRS Is Promoted by Allosteric Effects
[作者：Weinreb, V; Li, L; Campbell, CL; Kaguni, LS; Carter, CW,期刊：Structure, 页码：952-964 , 文章类型： Article，,卷期：2009年17-7]
- Mn2+-assisted catalysis by B. stearothermophilus TrpRS parallels that in polymerases and reduces specificity in amino acid activation. As predicted by nonequilibrium molecular dynamics simulations, multivariant thermodyn...
- Replication across Template T/U by Human DNA Polymerase-iota
[作者：Jain, R; Nair, DT; Johnson, RE; Prakash, L; Prakash, S; Aggarwal, AK,期刊：Structure, 页码：974-980 , 文章类型： Article，,卷期：2009年17-7]
- Human DNA polymerase-iota (POl iota) incorporates correct nucleotides opposite template purines with a much higher efficiency and fidelity than opposite template pyrimidines. In fact, the fidelity opposite template T is ...
- Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
[作者：Chowdhury, R; McDonough, MA; Mecinovic, J; Loenarz, C; Flashman, E; Hewitson, KS; Domene, C; Schofield, CJ,期刊：Structure, 页码：981-989 , 文章类型： Article，,卷期：2009年17-7]
- The oxygen-dependent hydroxylation of proline residues in the a subunit of hypoxia-inducible transcription factor (HIF alpha) is central to the hypoxic response in animals. Prolyl hydroxylation of HIFa increases its bind...
- EM-Fold: De Novo Folding of alpha-Helical Proteins Guided by Intermediate-Resolution Electron Microscopy Density Maps
[作者：Lindert, S; Staritzbichler, R; Wotzel, N; Karakas, M; Stewart, PL; Meiler, J,期刊：Structure, 页码：990-1003 , 文章类型： Article，,卷期：2009年17-7]
- In medium-resolution (7-10 angstrom) cryo-electron microscopy (cryo-EM) density maps, alpha helices can be identified as density rods whereas beta-strand or loop regions are not as easily discerned. We are proposing a co...
- Formation of the Complex between DsbD and PilB N-Terminal Domains from Neisseria meningitidis Necessitates an Adaptability of nDsbD
[作者：Quinternet, M; Tsan, P; Selme-Roussel, L; Jacob, C; Boschi-Muller, S; Branlant, G; Cung, MT,期刊：Structure, 页码：1024-1033 , 文章类型： Article，,卷期：2009年17-7]
- DsbD transmembrane protein dispatches electrons to periplasmic Trx/DsbE-like partners via specific interactions with its N-terminal domain, nDsbD. In the present study, PilB N-terminal domain (NterPilB) is shown to effic...
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