- Genetic p53 Deficiency Partially Rescues the Adrenocortical Dysplasia Phenotype at the Expense of Increased Tumorigenesis
[作者：Else, T; Trovato, A; Kim, AC; Wu, Y; Ferguson, DO; Kuick, RD; Lucas, PC; Hammer, GD,期刊：Cancer Cell, 页码：465-476 , 文章类型： Article，,卷期：2009年15-6]
- Telomere dysfunction and shortening induce chromosomal instability and tumorigenesis. In this study, we analyze the adrenocortical dysplasia (acd) mouse, harboring a mutation in Tpp1/Acd. Additional loss of p53 dramatica...
- Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression
[作者：Reuter, JA; Ortiz-Urda, S; Kretz, M; Garcia, J; Scholl, FA; Pasmooij, AMG; Cassarino, D; Chang, HY; Khavari, PA,期刊：Cancer Cell, 页码：477-488 , 文章类型： Article，,卷期：2009年15-6]
- To elucidate mechanisms of cancer progression, we generated inducible human neoplasia. in three-dimensionally intact epithelial tissue. Gene expression profiling of both epithelia and stroma at specific time points durin...
- A Gene Expression Signature Associated with "K-Ras Addiction" Reveals Regulators of EMT and Tumor Cell Survival
[作者：Singh, A; Greninger, P; Rhodes, D; Koopman, L; Violette, S; Bardeesy, N; Settleman, J,期刊：Cancer Cell, 页码：489-500 , 文章类型： Article，,卷期：2009年15-6]
- K-ras mutations occur frequently in epithelial cancers. Using short hairpin RNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-ras mutations, two classes were identified-lines that do or do not re...
- Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
[作者：Li, Z; Bao, S; Wu, Q; Wang, H; Eyler, C; Sathornsumetee, S; Shi, Q; Cao, Y; Lathia, J; McLendon, RE; Hjelmeland, AB; Rich, JN,期刊：Cancer Cell, 页码：501-513 , 文章类型： Article，,卷期：2009年15-6]
- Glioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by glioma stem cells (GSCs). Because hypoxia regulates angiogenesis, we examined hypoxic responses in GSCs. We now demonstrate that h...
- Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model
[作者：Wang, Y; Yang, J; Zheng, HR; Tomasek, GJ; Zhang, P; McKeever, PE; Lee, EYHP; Zhu, Y,期刊：Cancer Cell, 页码：514-526 , 文章类型： Article，,卷期：2009年15-6]
- Recent studies have identified genes and core pathways that are altered in human glioblastoma. However, the mechanisms by which alterations of these glioblastoma genes singly and cooperatively transform brain cells remai...
- Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment
[作者：Chan, DA; Kawahara, TLA; Sutphin, PD; Chang, HY; Chi, JT; Giaccia, AJ,期刊：Cancer Cell, 页码：527-538 , 文章类型： Article，,卷期：2009年15-6]
- Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the t...
- Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases
[作者：Liu, SY; Umezu-Goto, M; Murph, M; Lu, YL; Liu, WB; Zhang, F; Yu, SX; Stephens, LC; Cui, XJ; Murrow, G; Coombes, K; Muller, W; Hung, MC; Perou, CM; Lee, AV; Fang, XJ; Mills, GB,期刊：Cancer Cell, 页码：539-550 , 文章类型： Article，,卷期：2009年15-6]
- Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPL...
|