- A Double Hit to Kill Tumor and Endothelial Cells by TRAIL and Antiangiogenic 3TSR
[作者：Ren, B; Song, KL; Parangi, S; Jin, TG; Ye, M; Humphreys, R; Duquette, M; Zhang, XF; Benhaga, N; Lawler, J; Khosravi-Far, R,期刊：Cancer research, 页码：3856-3865 , 文章类型： Article，,卷期：2009年69-9]
- As tumor development relies on a coordination of angiogenesis and tumor growth, an efficient antitumor strategy should target both the tumor and its associated vessels. Tumor necrosis factor-related apoptosis-inducing li...
- eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
[作者：Graff, JR; Konicek, BW; Lynch, RL; Dumstorf, CA; Dowless, MS; McNulty, AM; Parsons, SH; Brail, LH; Colligan, BM; Koop, JW; Hurst, BM; Deddens, JA; Neubauer, BL; Stancato, LF; Carter, HW; Douglass, LE; Carter, JH,期刊：Cancer research, 页码：3866-3873 , 文章类型： Article，,卷期：2009年69-9]
- Elevated eukaryotic translation initiation factor 4E (eIF4E) function induces malignancy in experimental models by selectively enhancing translation of key malignancy-related mRNAs (c-myc and BCL-2). eIF4E activation may...
- Pharmacologic Abrogation of the Mitotic Spindle Checkpoint by an Indolocarbazole Discovered by Cellular Screening Efficiently Kills Cancer Cells
[作者：Stolz, A; Vogel, C; Schneider, V; Ertych, N; Kienitz, A; Yu, HT; Bastians, H,期刊：Cancer research, 页码：3874-3883 , 文章类型： Article，,卷期：2009年69-9]
- The mitotic spindle checkpoint represents a signal transduction pathway that prevents the onset of anaphase until all chromosomes are properly aligned on a metaphase plate. Partial inactivation of this checkpoint allows ...
- DNA Cross-Links in Human Tumor Cells Exposed to the Prodrug PR-104A: Relationships to Hypoxia, Bioreductive Metabolism, and Cytotoxicity
[作者：Singleton, RS; Guise, CP; Ferry, DM; Pullen, SM; Dorie, MJ; Brown, JM; Patterson, AV; Wilson, WR,期刊：Cancer research, 页码：3884-3891 , 文章类型： Article，,卷期：2009年69-9]
- PR-104, currently in clinical trial, is converted systemically to the dinitrobenzamide nitrogen mustard prodrug PR-104A, which is reduced selectively in hypoxic cells to cytotoxic hydroxylamine (PR-104H) and amine (PR-10...
- Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas
[作者：von Maltzahn, G; Park, JH; Agrawal, A; Bandaru, NK; Das, SK; Sailor, MJ; Bhatia, SN,期刊：Cancer research, 页码：3892-3900 , 文章类型： Article，,卷期：2009年69-9]
- Plasmonic nanomaterials have the opportunity to considerably improve the specificity of cancer ablation by i.v. homing to tumors and acting as antennas for accepting externally applied energy. Here, we describe an integr...
- K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells
[作者：Nakai, R; Iida, S; Takahashi, T; Tsujita, T; Okamoto, S; Takada, C; Akasaka, K; Ichikawa, S; Ishida, H; Kusaka, H; Akinaga, S; Murakata, C; Honda, S; Nitta, M; Saya, H; Yamashita, Y,期刊：Cancer research, 页码：3901-3909 , 文章类型： Article，,卷期：2009年69-9]
- The aim of this study was to investigate the mechanism of inhibition of Eg5 (kinesin spindle protein), a mitotic kinesin that plays an essential role in establishing mitotic spindle bipolarity, by the novel small molecul...
- Doxorubicin and Paclitaxel-Loaded Lipid-Based Nanoparticles Overcome Multidrug Resistance by Inhibiting P-Glycoprotein and Depleting ATP
[作者：Dong, XW; Mattingly, CA; Tseng, MT; Cho, MJ; Liu, Y; Adams, VR; Mumper, RJ,期刊：Cancer research, 页码：3918-3926 , 文章类型： Article，,卷期：2009年69-9]
- To test the ability of nanoparticle formulations to overcome P-glycoprotein (P-gp)-mediated multidrug resistance, several different doxorubicin and paclitaxel-loaded lipid nano-particles were prepared. Doxorubicin nanopa...
- Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-alpha Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors
[作者：McDermott, U; Ames, RY; Iafrate, AJ; Maheswaran, S; Stubbs, H; Greninger, P; McCutcheon, K; Milano, R; Tam, A; Lee, DY; Lucien, L; Brannigan, BW; Ulkus, LE; Ma, XJ; Erlander, MG; Haber, DA; Sharma, SV; Settleman, J,期刊：Cancer research, 页码：3937-3946 , 文章类型： Article，,卷期：2009年69-9]
- Platelet-derived growth factor (PDGF) receptors (PDGFR) and their ligands play critical roles in several human malignancies. Sunitinib is a clinically approved multitargeted tyrosine kinase inhibitor that inhibits vascul...
- PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor-Positive Breast Cancer
[作者：Crowder, RJ; Phommaly, C; Tao, Y; Hoog, J; Luo, JQ; Perou, CM; Parker, JS; Miller, MA; Huntsman, DG; Lin, L; Snider, J; Davies, SR; Olson, JA; Watson, MA; Saporita, A; Weber, JD; Ellis, MJ,期刊：Cancer research, 页码：3955-3962 , 文章类型： Article，,卷期：2009年69-9]
- Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between pharmacologic inhibition and somatic mutations in PI3K catalytic...
- Prevention of Spontaneous Tumor Development in a ret Transgenic Mouse Model by Ret Peptide Vaccination with Indoleamine 2,3-Dioxygenase Inhibitor 1-Methyl Tryptophan
[作者：Zeng, J; Cai, SH; Yi, YM; He, YW; Wang, Z; Jiang, GM; Li, XK; Du, J,期刊：Cancer research, 页码：3963-3970 , 文章类型： Article，,卷期：2009年69-9]
- The present study investigated an immunotherapeutic strategy for rearranged during transfection proto-oncogene (ret)associated carcinomas in a transgenic MT/ret 304/B6 mouse model in which spontaneous tumors develop due ...
- Catecholamines Regulate Tumor Angiogenesis
[作者：Chakroborty, D; Sarkar, C; Basu, B; Dasgupta, PS; Basu, S,期刊：Cancer research, 页码：3727-3730 , 文章类型： Review，,卷期：2009年69-9]
- Among the regulators of angiogenesis, catecholamine neuro-transmitters are of recent interest because of their opposite roles in the regulation of tumor neovascularization. Norepinephrine and epinephrine by acting throug...
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