- AZD1152 Rapidly and Negatively Affects the Growth and Survival of Human Acute Myeloid Leukemia Cells In vitro and In vivo
[作者：Oke, A; Pearce, D; Wilkinson, RW; Crafter, C; Odedra, R; Cavenagh, J; Fitzgibbon, J; Lister, AT; Joel, S; Bonnet, D,期刊：Cancer research, 页码：4150-4158 , 文章类型： Article，,卷期：2009年69-10]
- Aurora kinases play a critical role in regulating mitosis and cell division, and their overexpression has been implicated in the survival and proliferation of human cancer. In this study, we report the in vitro and in vi...
- Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
[作者：Steinkamp, MP; O'Mahony, OA; Brogley, M; Rehman, H; LaPensee, EW; Dhanasekaran, S; Hofer, MD; Kuefer, R; Chinnaiyan, A; Rubin, MA; Pienta, KJ; Robins, DM,期刊：Cancer research, 页码：4434-4442 , 文章类型： Article，,卷期：2009年69-10]
- Mutations in the androgen receptor (All) that enable activation by antiandrogens occur in hormone-refractory prostate cancer, suggesting that mutant ARs are selected by treatment. To validate this hypothesis, we compared...
- Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia
[作者：Agirre, X; Vilas-Zornoza, A; Jimenez-Velasco, A; Martin-Subero, JI; Cordeu, L; Garate, L; Jose-Eneriz, ES; Abizanda, G; Rodriguez-Otero, P; Fortes, P; Rifon, J; Bandres, E; Calasanz, MJ; Martin, V; Heiniger, A; Torres, A; Siebert, R; Roman-Gomez, J; Prosper, F,期刊：Cancer research, 页码：4443-4453 , 文章类型： Article，,卷期：2009年69-10]
- Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate that DNA methylation contributes to dow...
- The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells
[作者：Ulrich, TA; Pardo, EMD; Kumar, S,期刊：Cancer research, 页码：4167-4174 , 文章类型： Article，,卷期：2009年69-10]
- Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system associated with a median survival time of 15 months, even with aggressive therapy. This rapid progression is due in part to diffuse i...
- Complex Oncogenic Translocations with Gene Amplification Are Initiated by Specific DNA Breaks in Lymphocytes
[作者：Wright, SM; Woo, YH; Alley, TL; Shirley, BJ; Akeson, EC; Snow, KJ; Maas, SA; Elwell, RL; Foreman, O; Mills, KD,期刊：Cancer research, 页码：4454-4460 , 文章类型： Article，,卷期：2009年69-10]
- Chromosomal instability is a hallmark of many tumor types. Complex chromosomal rearrangements with associated gene amplification, known as complicons, characterize many hematologic and solid cancers. Whereas chromosomal ...
- Lack of T-Cell Receptor-Induced Signaling Is Crucial for CD95 Ligand Up-regulation and Protects Cutaneous T-Cell Lymphoma Cells from Activation-Induced Cell Death
[作者：Klemke, CD; Brenner, D; Weiss, EM; Schmidt, M; Leverkus, M; Gulow, K; Krammer, PH,期刊：Cancer research, 页码：4175-4183 , 文章类型： Article，,卷期：2009年69-10]
- Restimulation of previously activated T cells via the T-cell receptor (TCR) leads to activation-induced cell death (AICD), which is, at least in part, dependent on the death receptor CD95 (APO-1, FAS) and its natural lig...
- Host Genetic Variants in the Interleukin-6 Promoter Predict Poor Outcome in Patients with Estrogen Receptor-Positive, Node-Positive Breast Cancer
[作者：DeMichele, A; Gray, R; Horn, M; Chen, JB; Aplenc, R; Vaughan, WP; Tallman, MS,期刊：Cancer research, 页码：4184-4191 , 文章类型： Article，,卷期：2009年69-10]
- Interleukin-6 modulates immune response, estrogen production, and growth pathways in breast cancer. We evaluated the effect of several common, functional interleukin-6 promoter variants in node-positive breast cancer pat...
- Endoplasmic Reticulum Stress Triggers XBP-1-Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma
[作者：Hsiao, JR; Chang, KC; Chen, CW; Wu, SY; Su, IJ; Hsu, MC; Jin, YT; Tsai, ST; Takada, K; Chang, Y,期刊：Cancer research, 页码：4461-4467 , 文章类型： Article，,卷期：2009年69-10]
- Endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR) plays multiple roles in cancer development, but its specific roles for virus-associated cancers have not been fully understood. It is still unkn...
- 3,3 '-Diindolylmethane Enhances Taxotere-Induced Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-regulation
[作者：Rahman, KMW; Banerjee, S; Ali, S; Ahmad, A; Wang, ZW; Kong, DJ; Sakr, WA,期刊：Cancer research, 页码：4468-4475 , 文章类型： Article，,卷期：2009年69-10]
Survivin, a member of inhibitor of apoptosis family, is associated with both prostate cancer progression and drug resistance. Therefore, we hypothesized that survivin may play a potentially important role in hormone-r...
- Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer
[作者：Miller, TW; Perez-Torres, M; Narasanna, A; Guix, M; Stal, O; Perez-Tenorio, G; Gonzalez-Angulo, AM; Hennessy, BT; Mills, GB; Kennedy, JP; Lindsley, CW; Arteaga, CL,期刊：Cancer research, 页码：4192-4201 , 文章类型： Article，,卷期：2009年69-10]
- Knockdown of the tumor suppressor phosphatase Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) with shRNA in three estrogen receptor (ER)-positive breast cancer cell lines resulted in increased phosphatid...
- Association between Rectal Optical Signatures and Colonic Neoplasia: Potential Applications for Screening
[作者：Roy, HK; Turzhitsky, V; Kim, Y; Goldberg, MJ; Watson, P; Rogers, JD; Gomes, AJ; Kromine, A; Brand, RE; Jameel, M; Bogovejic, A; Pradhan, P; Backman, V,期刊：Cancer research, 页码：4476-4483 , 文章类型： Article，,卷期：2009年69-10]
- Field carcinogenesis detection represents a promising means for colorectal cancer (CRC) screening, although current techniques (e.g., flexible sigmoidoscopy) lack the requisite sensitivity. The novel optical technology l...
- Prediction of Drug Response in Breast Cancer Using Integrative Experimental/Computational Modeling
[作者：Frieboes, HB; Edgerton, ME; Fruehauf, JP; Rose, FRAJ; Worrall, LK; Gatenby, RA; Ferrari, M; Cristini, V,期刊：Cancer research, 页码：4484-4492 , 文章类型： Article，,卷期：2009年69-10]
- Nearly 30% of women with early-stage breast cancer develop recurrent disease attributed to resistance to systemic therapy. Prevailing models of chemotherapy failure describe three resistant phenotypes: cells with alterat...
- Multiparameter Computational Modeling of Tumor Invasion
[作者：Bearer, EL; Lowengrub, JS; Frieboes, HB; Chuang, YL; Jin, F; Wise, SM; Ferrari, M; Agus, DB; Cristini, V,期刊：Cancer research, 页码：4493-4501 , 文章类型： Article，,卷期：2009年69-10]
- Clinical outcome prognostication in oncology is a guiding principle in therapeutic choice. A wealth of qualitative empirical evidence links disease progression with tumor morphology, histopathology, invasion, and associa...
- Heregulin Regulates Prolactinoma Gene Expression
[作者：Vlotides, G; Cooper, O; Chen, YH; Ren, SG; Greenman, Y; Melmed, S,期刊：Cancer research, 页码：4209-4216 , 文章类型： Article，,卷期：2009年69-10]
- To investigate the role of p185(her2/neu)/ErbB3 signaling in pituitary tumor function, we examined these receptors in human prolactinomas. Immunofluorescent p185(her2/neu) was detected in almost. all (seven of eight), an...
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