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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共49条记录   AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects [作者：Davies, NJ; Hayden, RE; Simpson, PJ; Birtwistle, J; Mayer, K; Ride, JP; Bunce, CM,期刊：Cancer research, 页码：4769-4775 , 文章类型： Article，,卷期：2009年69-11] Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of the pathology of cancer. Agents that inhibit these enzymes may provide novel agents for eithe... Expression of the K303R Estrogen Receptor-alpha Breast Cancer Mutation Induces Resistance to an Aromatase Inhibitor via Addiction to the PI3K/Akt Kinase Pathway [作者：Barone, I; Cui, YK; Herynk, MH; Corona-Rodriguez, A; Giordano, C; Selever, J; Beyer, A; Ando, S; Fuqua, SAW,期刊：Cancer research, 页码：4724-4732 , 文章类型： Article，,卷期：2009年69-11] Aromatase inhibitors (AI) are rapidly becoming the first choice for hormonal treatment of estrogen receptor-alpha (ER alpha)-positive breast cancer in postmenopausal women. However, de novo and acquired resistance freque... KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model [作者：Difeo, A; Huang, F; Sangodkar, J; Terzo, EA; Leake, D; Narla, G; Martignetti, JA,期刊：Cancer research, 页码：4733-4741 , 文章类型： Article，,卷期：2009年69-11] Defects in apoptosis are not only a hallmark of cancer initiation and progression but can also underlie the development of chemoresistance. How the tightly regulated cascade of protein-protein interactions between member... Estrogen Receptor-beta Affects the Prognosis of Human Malignant Mesothelioma [作者：Pinton, G; Brunelli, E; Murer, B; Puntoni, R; Puntoni, M; Fennell, DA; Gaudino, G; Mutti, L; Moro, L,期刊：Cancer research, 页码：4598-4604 , 文章类型： Article，,卷期：2009年69-11] Malignant pleural mesothelioma is an asbestos-related neoplasm with poor prognosis, refractory to current therapies, the incidence of which is expected to increase in the next decades. Female gender was identified as a p... Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway [作者：Courtwright, A; Siamakpour-Reihani, S; Arbiser, JL; Banet, N; Hilliard, E; Fried, L; Livasy, C; Ketelsen, D; Nepal, DB; Perou, CM; Patterson, C; Klauber-DeMore, N,期刊：Cancer research, 页码：4621-4628 , 文章类型： Article，,卷期：2009年69-11] Secreted frizzle-related protein 2 (SFRP2), a modulator of Wnt signaling, has recently been found to be overexpressed in the vasculature of 85% of human breast tumors; however, its role in angiogenesis is unknown. We fou... NORE1A Tumor Suppressor Candidate Modulates p21(CIP1) via p53 [作者：Calvisi, DF; Donninger, H; Vos, MD; Birrer, MJ; Gordon, L; Leaner, V; Clark, GJ,期刊：Cancer research, 页码：4629-4637 , 文章类型： Article，,卷期：2009年69-11] NORE1A (RASSF5) is a proapoptotic Ras effector that is frequently inactivated by promoter methylation in human tumors. It is structurally related to the RASSF1A tumor suppressor and is itself implicated as a tumor suppre... Circadian Rhythm in Rest and Activity: A Biological Correlate of Quality of Life and a Predictor of Survival in Patients with Metastatic Colorectal Cancer [作者：Innominato, PF; Focan, C; Gorlia, T; Moreau, T; Garufi, C; Waterhouse, J; Giacchetti, S; Coudert, B; Iacobelli, S; Genet, D; Tampellini, M; Chollet, P; Lentz, MA; Mormont, MC; Levi, F; Bjarnason, GA,期刊：Cancer research, 页码：4700-4707 , 文章类型： Proceedings Paper，,卷期：2009年69-11] The rest-activity circadian rhythm (CircAct) reflects the function of the circadian timing system. In a prior single-institution study, the extent of CircAct perturbation independently predicted for survival and tumor re... Crystalline Camptothecin-20(S)-O-Propionate Hydrate: A Novel Anticancer Agent with Strong Activity against 19 Human Tumor Xenografts [作者：Cao, ZS; Kozielski, A; Liu, X; Wang, Y; Vardeman, D; Giovanella, B,期刊：Cancer research, 页码：4742-4749 , 文章类型： Article，,卷期：2009年69-11] To find a more effective and less toxic chemotherapeutic agent, we have successfully prepared crystalline camptothecin-20(S)-O-propionate hydrate (CZ48) by reacting camptothecin with propionic anhydride using concentrate... Aurora-A and hBora Join the Game of Polo [作者：Macurek, L; Lindqvist, A; Medema, RH,期刊：Cancer research, 页码：4555-4558 , 文章类型： Review，,卷期：2009年69-11] Overactivation of both Polo-like kinase-1 (Plk1) and Aurora-A is linked to cancer development, and small-molecule inhibitors that target these kinases are currently tested as anticancer drugs. Here, we discuss recent adv... CAR Mechanics: Driving T Cells into the MUC of Cancer [作者：Maher, J; Wilkie, S,期刊：Cancer research, 页码：4559-4562 , 文章类型： Review，,卷期：2009年69-11] Several monoclonal antibodies bind in a highly selective manner to tumor-associated glycoforms of MUC1. We set out to exploit this by developing a MUC1-specific chimeric antigen receptor. Difficulties were encountered in... Up-regulation of C-Terminal Tensin-like Molecule Promotes the Tumorigenicity of Colon Cancer through beta-Catenin [作者：Liao, YC; Chen, NT; Shih, YP; Dong, Y; Lo, SH,期刊：Cancer research, 页码：4563-4566 , 文章类型： Article，,卷期：2009年69-11] C-terminal tensin-like (cten) is a focal adhesion molecule belonging to the tensin family. Previous studies have suggested that cten may function as a prostate-specific tumor suppressor. Here, we show that although cten ... The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase [作者：Costantino, CL; Witkiewicz, AK; Kuwano, Y; Cozzitorto, JA; Kennedy, EP; Dasgupta, A; Keen, JC; Yeo, CJ; Gorospe, M; Brody, JR,期刊：Cancer research, 页码：4567-4572 , 文章类型： Article，,卷期：2009年69-11] RNA-binding protein HuR binds U- or AU-rich sequences in the 3'-untranslated regions of target mRNAs, stabilizing them and/or modulating their translation. Given the links of HuR with cancer, we studied the consequences ... Src Stimulates Fibroblast Growth Factor Receptor-2 Shedding by an ADAM15 Splice Variant Linked to Breast Cancer [作者：Maretzky, T; Le Gall, SM; Worpenberg-Pietruk, S; Eder, J; Overall, CM; Huang, XY; Poghosyan, Z; Edwards, DR; Blobel, CP,期刊：Cancer research, 页码：4573-4576 , 文章类型： Article，,卷期：2009年69-11] ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was li... Combined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation [作者：Paternot, S; Roger, PP,期刊：Cancer research, 页码：4577-4581 , 文章类型： Article，,卷期：2009年69-11] The Ras/Raf/MEK/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (mTOR) signaling pathways are aberrantly activated in many tumors, including highly prolifer... Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells [作者：Arias-Romero, LE; Saha, S; Villamar-Cruz, O; Yip, SC; Ethier, SP; Zhang, ZY; Chernoff, J,期刊：Cancer research, 页码：4582-4588 , 文章类型： Article，,卷期：2009年69-11] Protein tyrosine phosphatase (PTP) 1B plays a major role in inhibiting signaling from the insulin and leptin receptors. Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of... Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor-kappa B Family [作者：Fan, G; Fan, Y; Gupta, N; Matsuura, I; Liu, F; Zhou, XZ; Lu, KP; Gelinas, C,期刊：Cancer research, 页码：4589-4597 , 文章类型： Article，,卷期：2009年69-11] The peptidyl-prolyl isomerase Pin1 is frequently up-regulated in human cancers in which Rel/nuclear factor-kappa B (NF-kappa B) is constitutively activated, but its role in these cancers remains to be determined, and evi...