- PUMA Suppresses Intestinal Tumorigenesis in Mice
[作者：Qiu, W; Carson-Walter, EB; Kuan, SF; Zhang, L; Yu, J,期刊：Cancer research, 页码：4999-5006 , 文章类型： Article，,卷期：2009年69-12]
- Defective apoptosis contributes to tumorigenesis, although the critical molecular targets remain to be fully characterized. PUMA, a BH3-only protein essential for p53-dependent apoptosis, has been shown to suppress lymph...
- Extracellular Engagement of alpha(6) Integrin Inhibited Urokinase-Type Plasminogen Activator-Mediated Cleavage and Delayed Human Prostate Bone Metastasis
[作者：Ports, MO; Nagle, RB; Pond, GD; Cress, AE,期刊：Cancer research, 页码：5007-5014 , 文章类型： Article，,卷期：2009年69-12]
- Expression of alpha(6) integrin, a laminin receptor, on tumor cell surfaces is associated with reduced patient survival and increased metastasis in a variety of tumors. In prostate cancer, tumor extracapsular escape occu...
- Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells
[作者：Meurette, O; Stylianou, S; Rock, R; Collu, GM; Gilmore, AP; Brennan, K,期刊：Cancer research, 页码：5015-5022 , 文章类型： Article，,卷期：2009年69-12]
The Notch pathway is aberrantly activated in a wide range of cancers, including breast carcinoma, and is required to maintain the transformed phenotype of many of these tumors. Notch signaling contributes to the trans...
- Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis
[作者：Agiostratidou, G; Li, MM; Suyama, K; Badano, I; Keren, R; Chung, S; Anzovino, A; Hulit, J; Qian, BZ; Bouzahzah, B; Eugenin, E; Loudig, O; Phillips, GR; Locker, J; Hazan, RB,期刊：Cancer research, 页码：5030-5038 , 文章类型： Article，,卷期：2009年69-12]
- The mammary epithelium is thought to be stabilized by cell-cell adhesion mediated mainly by E-cadherin (E-cad). Here, we show that another cadherin, retinal cadherin (R-cad), is critical for maintenance of the epithelial...
- The Activated Notch1 Signal Pathway Is Associated with Gastric Cancer Progression through Cyclooxygenase-2
[作者：Yeh, TS; Wu, CW; Hsu, KW; Liao, WJ; Yang, MC; Li, AFY; Wang, AM; Kuo, ML; Chi, CW,期刊：Cancer research, 页码：5039-5048 , 文章类型： Article，,卷期：2009年69-12]
- Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To understand the pathogenesis and to develop ...
- TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, Is Highly Phosphorylated, and Indicates Poor Prognosis in Node-Negative Breast Cancer
[作者：Helms, MW; Kemming, D; Contag, CH; Pospisil, H; Bartkowiak, K; Wang, A; Chang, SY; Buerger, H; Brandt, BH,期刊：Cancer research, 页码：5049-5056 , 文章类型： Article，,卷期：2009年69-12]
- Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 and epidermal growth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer. In a cellular mod...
- Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression
[作者：Dillon, RL; Marcotte, R; Hennessy, BT; Woodgett, JR; Mills, GB; Muller, WJ,期刊：Cancer research, 页码：5057-5064 , 文章类型： Article，,卷期：2009年69-12]
- The phosphatidylinositol 3-kinase (PI3K)/Akt survival pathway is often dysregulated in cancer. Our previous studies have shown that coexpression of activated Akt1 with activated ErbB2 or polyoma virus middle T antigen un...
- Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations
[作者：Wu, C; Hu, ZB; Yu, DK; Huang, LM; Jin, GG; Liang, J; Guo, H; Tan, W; Zhang, MF; Qian, J; Lu, DR; Wu, TC; Lin, DX; Shen, HB,期刊：Cancer research, 页码：5065-5072 , 文章类型： Article，,卷期：2009年69-12]
- Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are extremely rare in Asian...
- In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT
[作者：Moses, SA; Ali, MA; Song, ZH; Lei, DC; Zhou, LL; Lemos, R; Ihle, N; Skillman, AG; Zhang, SX; Mash, EA; Powis, G; Meuillet, EJ,期刊：Cancer research, 页码：5073-5081 , 文章类型： Article，,卷期：2009年69-12]
- The phosphatidylinositol 3-kinase/AKT signaling pathway plays a critical role in activating survival and antiapoptotic pathways within cancer cells. Several studies have shown that this pathway is constitutively activate...
- Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1 alpha-Dependent Pathway in Multiple Myeloma
[作者：Zhang, J; Sattler, M; Tonon, G; Grabher, C; Lababidi, S; Zimmerhackl, A; Raab, MS; Vallet, S; Zhou, YM; Cartron, MA; Hideshima, T; Tai, YT; Chauhan, D; Anderson, KC; Podar, K,期刊：Cancer research, 页码：5082-5090 , 文章类型： Article，,卷期：2009年69-12]
- Bone marrow angiogenesis is associated with multiple myeloma (MM) progression. Here, we report high constitutive hypoxia-inducible factor-1 alpha (Hif-1 alpha) expression in MM cells, which is associated with oncogenic c...
- Effects of Vandetanib on Lung Adenocarcinoma Cells Harboring Epidermal Growth Factor Receptor T790M Mutation In vivo
[作者：Ichihara, E; Ohashi, K; Takigawa, N; Osawa, M; Ogino, A; Tanimoto, M; Kiura, K,期刊：Cancer research, 页码：5091-5098 , 文章类型： Article，,卷期：2009年69-12]
- Vandetanib is a novel multitarget tyrosine kinase inhibitor (TKI) that inhibits vascular endothelial growth factor receptor-2 (VEGFR-2), with additional inhibition of epidermal growth factor receptor (EGFR) and rearrange...
- Human Schwannomas Express Activated Platelet-Derived Growth Factor Receptors and c-kit and Are Growth Inhibited by Gleevec (Imatinib Mesylate)
[作者：Mukherjee, J; Kamnasaran, D; Balasubramaniam, A; Radovanovic, I; Zadeh, G; Kiehl, TR; Guha, A,期刊：Cancer research, 页码：5099-5107 , 文章类型： Article，,卷期：2009年69-12]
- Schwannomas, although benign, can be fatal or give rise to significant morbidity due to an unpredictable growth rate. They can reoccur after surgery or radiation, current treatments each with significant inherent risks. ...
- Role of Cell Cycle in Epidermal Growth Factor Receptor Inhibitor-Mediated Radiosensitization
[作者：Ahsan, A; Hiniker, SM; Davis, MA; Lawrence, TS; Nyati, MK,期刊：Cancer research, 页码：5108-5114 , 文章类型： Article，,卷期：2009年69-12]
- Epidermal growth factor receptor (EGFR) inhibitors are increasingly used in combination with radiotherapy in the treatment of various EGFR-overexpressing cancers. However, little is known about the effects of cell cycle ...
- Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses
[作者：Strauss, R; Sova, P; Liu, Y; Li, ZY; Tuve, S; Pritchard, D; Brinkkoetter, P; Moller, T; Wildner, O; Pesonen, S; Hemminki, A; Urban, N; Drescher, C; Lieber, A,期刊：Cancer research, 页码：5115-5125 , 文章类型： Article，,卷期：2009年69-12]
- We studied the susceptibility of primary ovarian cancer cells to oncolytic adenoviruses. Using gene expression profiling of cancer cells either resistant or susceptible to viral oncolysis, we discovered that the epitheli...
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