- Modification of Ovarian Cancer Risk by BRCA1/2-interacting Genes in a Multicenter Cohort of BRCA1/2 Mutation Carriers
[作者：Rebbeck, TR; Mitra, N; Domchek, SM; Wan, F; Chuai, S; Friebel, TM; Panossian, S; Spurdle, A; Chenevix-Trench, G; Singer, CF; Pfeiler, G; Neuhausen, SL; Lynch, HT; Garber, JE; Weitzel, JN; Isaacs, C; Couch, F; Narod, SA; Rubinstein, WS; Tomlinson, GE; Ganz, PA; Olopade, OI; Tung, N; Blum, JL; Greenberg, R; Nathanson, KL; Daly, MB,期刊：Cancer research, 页码：5801-5810 , 文章类型： Article，,卷期：2009年69-14]
- Inherited BRCA1/2 mutations confer elevated ovarian cancer risk. Knowledge of factors that can improve ovarian cancer risk assessment in BRCA1/2 mutation carriers is important because no effective early detection for ova...
- Analysis of the Human Cancer Glycome Identifies a Novel Group of Tumor-Associated N-Acetylglucosamine Glycan Antigens
[作者：Satomaa, T; Heiskanen, A; Leonardsson, I; Angstrom, J; Olonen, A; Blomqvist, M; Salovuori, N; Haglund, C; Teneberg, S; Natunen, J; Carpen, O; Saarinen, J,期刊：Cancer research, 页码：5811-5819 , 文章类型： Article，,卷期：2009年69-14]
- The cell surface is covered by a dense layer of protein- and lipid-linked glycans. Although it has been known that distinct glycan structures are associated with cancer, the whole spectrum of cancer-associated glycans ha...
- Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
[作者：Arumugam, T; Ramachandran, V; Fournier, KF; Wang, HM; Marquis, L; Abbruzzese, JL; Gallick, GE; Logsdon, CD; McConkey, DJ; Choi, W,期刊：Cancer research, 页码：5820-5828 , 文章类型： Article，,卷期：2009年69-14]
- A better understanding of drug resistance mechanisms is required to improve outcomes in patients with pancreatic cancer. Here, we characterized patterns of sensitivity and resistance to three conventional chemotherapeuti...
- Preclinical Development of a Bifunctional Cancer Cell Homing, PKC epsilon Inhibitory Peptide for the Treatment of Head and Neck Cancer
[作者：Bao, LW; Gorin, MA; Zhang, MC; Ventura, AC; Pomerantz, WC; Merajver, SD; Teknos, TN; Mapp, AK; Pan, Q,期刊：Cancer research, 页码：5829-5834 , 文章类型： Article，,卷期：2009年69-14]
- Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide, comprising similar to 50% of all malignancies in some developing nations. Our recent work identified protein kinase C epsilon (PK...
- Antimyeloma Activity of the Orally Bioavailable Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235
[作者：McMillin, DW; Ooi, M; Delmore, J; Negri, J; Hayden, P; Mitsiades, N; Jakubikova, J; Maira, SM; Garcia-Echeverria, C; Schlossman, R; Munshi, NC; Richardson, PG; Anderson, KC; Mitsiades, CS,期刊：Cancer research, 页码：5835-5842 , 文章类型： Article，,卷期：2009年69-14]
- The phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway mediates proliferation, survival, and drug resistance in multiple myeloma (MM) cells. Here, we tested the anti-MM activity of NVP-...
- Targeted In vivo Imaging of Integrin alpha(v)beta(6) with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model
[作者：Hausner, SH; Abbey, CK; Bold, RJ; Gagnon, MK; Marik, J; Marshall, JF; Stanecki, CE; Sutcliffe, JL,期刊：Cancer research, 页码：5843-5850 , 文章类型： Article，,卷期：2009年69-14]
- The cell surface receptor alpha(v)beta(6) is epithelial specific, and its expression is tightly regulated; it is low or undetectable in adult tissues but has been shown to he increased in many different cancers, includin...
- Platelets: Guardians of Tumor Vasculature
[作者：Ho-Tin-Noe, B; Goerge, T; Wagner, DD,期刊：Cancer research, 页码：5623-5626 , 文章类型： Review，,卷期：2009年69-14]
- Solid tumors generate a prothrombotic environment capable of platelet activation. Recent findings indicate that the activated platelets are crucial regulators of tumor vascular homeostasis in that they prevent tumor hemo...
- Sample Type Bias in the Analysis of Cancer Genomes
[作者：Solomon, DA; Kim, JS; Ressom, HW; Sibenaller, Z; Ryken, T; Jean, W; Bigner, D; Yan, H; Waldman, T,期刊：Cancer research, 页码：5630-5633 , 文章类型： Article，,卷期：2009年69-14]
- There is widespread agreement that cancer gene discovery requires high-quality tumor samples. However, whether primary tumors or cultured samples are superior for cancer genomics has been a longstanding subject of debate...
- Identification of Inhibitors of ABCG2 by a Bioluminescence Imaging-Based High-Throughput Assay
[作者：Zhang, YM; Byun, Y; Ren, YRZ; Liu, JO; Laterra, J; Pomper, MG,期刊：Cancer research, 页码：5867-5875 , 文章类型： Article，,卷期：2009年69-14]
- ABCG2 is a member of the ATP-binding cassette (ABC) family of transporters, the overexpression of which is associated with tumor resistance to a variety of chemotherapeutic agents. Accordingly, combining ABCG2 inhibitor(...
- Protein Kinase D Regulates Cell Migration by Direct Phosphorylation of the Cofilin Phosphatase Slingshot 1 Like
[作者：Peterburs, P; Heering, J; Link, G; Pfizenmaier, K; Olayioye, MA; Hausser, A,期刊：Cancer research, 页码：5634-5638 , 文章类型： Article，,卷期：2009年69-14]
- Protein kinase D (PKD) has been identified as a negative regulator of epithelial cell migration; however, its molecular substrates and downstream signaling pathways that mediate this activity have remained elusive. In th...
- MicroRNA-661, a c/EBP alpha Target, Inhibits Metastatic Tumor Antigen 1 and Regulates Its Functions
[作者：Divijendra, S; Reddy, N; Pakala, SB; Ohshiro, K; Rayala, SK; Kumar, R,期刊：Cancer research, 页码：5639-5642 , 文章类型： Article，,卷期：2009年69-14]
- MicroRNAs (miR) have been identified as posttranscriptional modifiers of target gene regulation and control the expression of gene products important in cancer progression. Here, we show that miR-661 inhibits the express...
- Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells
[作者：Thoennissen, NH; Iwanski, GB; Doan, NB; Okamoto, R; Lin, P; Abbassi, S; Song, JH; Yin, D; Toh, M; Xie, WD; Said, JW; Koeffler, HP,期刊：Cancer research, 页码：5876-5884 , 文章类型： Article，,卷期：2009年69-14]
Pancreatic cancer is an aggressive malignancy that is generally refractory to chemotherapy, thus posing experimental and clinical challenges. In this study, the antiproliferative effect of the triterpenoid compound cu...
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