- Outcome of Patients With Early-Stage Breast Cancer Treated With Doxorubicin-Based Adjuvant Chemotherapy As a Function of HER2 and TOP2A Status
[作者:Tubbs, R; Barlow, WE; Budd, GT; Swain, E; Porter, P; Gown, A; Yeh, IT; Sledge, G; Shapiro, C; Ingle, J; Haskell, C; Albain, KS; Livingston, R; Hayes, DF,期刊:Journal of clinical oncology, 页码:3881-3886 , 文章类型: Article,,卷期:2009年27-24]
- PurposeAmplification and deletion of the TOP2A gene have been reported as positive predictive markers of response to anthracycline-based therapy. We determined the status of the HER2 and TOP2A genes in a large cohort of ...
- Lung Dose-Volume Parameters and the Risk of Pneumonitis for Patients Treated With Accelerated Partial-Breast Irradiation Using Three-Dimensional Conformal Radiotherapy
[作者:Recht, A; Ancukiewicz, M; El-Din, MAA; Lu, XQ; Martin, C; Berman, SM; Hirsch, AE; Kachnic, LA; Katz, A; MacDonald, S; Nedea, EA; Stevenson, MA; Powell, SN; Taghian, AG,期刊:Journal of clinical oncology, 页码:3887-3893 , 文章类型: Article,,卷期:2009年27-24]
- PurposeThere are no data on how complication rates after accelerated partial-breast irradiation delivered by three-dimensional conformal radiotherapy are affected by treatment technique. We therefore examined the risk of...
- Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers
[作者:Watson, P; Lieberman, R; Snyder, C; Clark, VJ; Lynch, HT; Holt, JT,期刊:Journal of clinical oncology, 页码:3894-3900 , 文章类型: Article,,卷期:2009年27-24]
- PurposeMutations in the BRCA2 gene are dominantly inherited but cause cancers when the wild-type allele has loss of heterozygosity (LOH) within the cancer. Because most disease-associated BRCA2 mutations are protein-trun...
- Radiation Dose and Breast Cancer Risk in the Childhood Cancer Survivor Study
[作者:Inskip, PD; Robison, LL; Stovall, M; Smith, SA; Hammond, S; Mertens, AC; Whitton, JA; Diller, L; Kenney, L; Donaldson, SS; Meadows, AT; Neglia, JP,期刊:Journal of clinical oncology, 页码:3901-3907 , 文章类型: Article,,卷期:2009年27-24]
- PurposeThe purpose of this study was to quantify the risk of breast cancer in relation to radiation dose and chemotherapy among survivors of childhood cancer.MethodsWe conducted a case-control study of breast cancer in a...
- Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor 2 (HER2), and Epidermal Growth Factor Receptor Expression and Benefit From Lapatinib in a Randomized Trial of Paclitaxel With Lapatinib or Placebo As First-Line Treatment in HER2-Negative or Unknown Metastatic Breast Cancer
[作者:Finn, RS; Press, MF; Dering, J; Arbushites, M; Koehler, M; Oliva, C; Williams, LS; Di Leo, A,期刊:Journal of clinical oncology, 页码:3908-3915 , 文章类型: Article,,卷期:2009年27-24]
- PurposeLapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with activity in HER2-amplified metastatic breast cancer (MBC). Its role in non-HER2-amp...
- Individualizing Quality-of-Life Outcomes Reporting: How Localized Prostate Cancer Treatments Affect Patients With Different Levels of Baseline Urinary, Bowel, and Sexual Function
[作者:Chen, RC; Clark, JA; Talcott, JA,期刊:Journal of clinical oncology, 页码:3916-3922 , 文章类型: Article,,卷期:2009年27-24]
- PurposeAlthough it is the most powerful predictor of early prostate cancer treatment-related complications and quality-of-life (QOL) outcomes, most studies do not stratify results by baseline function. Further, reporting...
- Risk of Death From Prostate Cancer After Brachytherapy Alone or With Radiation, Androgen Suppression Therapy, or Both in Men With High-Risk Disease
[作者:D'Amico, AV; Moran, BJ; Braccioforte, MH; Dosoretz, D; Salenius, S; Katin, M; Ross, R; Chen, MH,期刊:Journal of clinical oncology, 页码:3923-3928 , 文章类型: Article,,卷期:2009年27-24]
- PurposeWe estimated the risk of prostate cancer (PC) -specific mortality (PCSM) after brachytherapy alone or in conjunction with androgen suppression therapy (AST), external-beam radiation therapy (EBRT), or both in men ...
- Generation of a Concise Gene Panel for Outcome Prediction in Urinary Bladder Cancer
[作者:Mitra, AP; Pagliarulo, V; Yang, DY; Waldman, FM; Datar, RH; Skinner, DG; Groshen, S; Cote, RJ,期刊:Journal of clinical oncology, 页码:3929-3937 , 文章类型: Article,,卷期:2009年27-24]
- PurposeThis study sought to determine if alterations in molecular pathways could supplement TNM staging to more accurately predict clinical outcome in patients with urothelial carcinoma (UC).Patients and MethodsExpressio...
- Presentation of Nonfinal Results of Randomized Controlled Trials at Major Oncology Meetings
[作者:Booth, CM; Le Maitre, A; Ding, KY; Farn, K; Fralick, M; Phillips, C; Cescon, DW; Meyer, RM,期刊:Journal of clinical oncology, 页码:3938-3944 , 文章类型: Article,,卷期:2009年27-24]
- PurposeTo assess the frequency, implications, and factors associated with reporting nonfinal analyses (NFAs) of randomized controlled trials (RCTs) as abstract publications.MethodsWe identified 138 consecutive reports of...
- Hospital Factors and Racial Disparities in Mortality After Surgery for Breast and Colon Cancer
[作者:Breslin, TM; Morris, AM; Gu, NY; Wong, SL; Finlayson, EV; Banerjee, M; Birkmeyer, JD,期刊:Journal of clinical oncology, 页码:3945-3950 , 文章类型: Article,,卷期:2009年27-24]
- PurposeBlack patients have worse prognoses than whites with breast or colorectal cancer. Mechanisms underlying such disparities have not been fully explored. We examined the role of hospital factors in racial differences...
- Allogeneic Stem Cell Transplantation Is Able to Induce Long-Term Remissions in Angioimmunoblastic T-Cell Lymphoma: A Retrospective Study From the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
[作者:Kyriakou, C; Canals, C; Finke, J; Kobbe, G; Harousseau, JL; Kolb, HJ; Novitzky, N; Goldstone, AH; Sureda, A; Schmitz, N,期刊:Journal of clinical oncology, 页码:3951-3958 , 文章类型: Article,,卷期:2009年27-24]
- PurposeTo analyze the long-term outcome in terms of nonrelapse mortality (NRM), relapse rate (RR), progression-free survival (PFS), and overall survival (OS) in patients with angioimmunoblastic T-cell lymphoma (AITL) tre...
- Brief Report: Natural History of Individuals With Clinically Recognized Monoclonal B-Cell Lymphocytosis Compared With Patients With Rai 0 Chronic Lymphocytic Leukemia
[作者:Shanafelt, TD; Kay, NE; Rabe, KG; Call, TG; Zent, CS; Maddocks, K; Jenkins, G; Jelinek, DF; Morice, WG; Boysen, J; Schwager, S; Bowen, D; Slager, SL; Hanson, CA,期刊:Journal of clinical oncology, 页码:3959-3963 , 文章类型: Article,,卷期:2009年27-24]
- PurposeThe diagnosis of monoclonal B-cell lymphocytosis (MBL) is used to characterize patients with a circulating population of clonal B cells, a total B-cell count of less than 5 X 10(9)/L, and no other features of a B-...
- Absence of Progression As Assessed by Response Evaluation Criteria in Solid Tumors Predicts Survival in Advanced GI Stromal Tumors Treated With Imatinib Mesylate: The Intergroup EORTC-ISG-AGITG Phase III Trial
[作者:Le Cesne, A; Van Glabbeke, M; Verweij, J; Casali, PG; Findlay, M; Reichardt, P; Issels, R; Judson, I; Schoffski, P; Leyvraz, S; Bui, B; Hogendoorn, PCW; Sciot, R; Blay, JY,期刊:Journal of clinical oncology, 页码:3969-3974 , 文章类型: Article,,卷期:2009年27-24]
- PurposeFrom February 2001 to February 2002, 946 patients with advanced GI stromal tumors (GISTs) treated with imatinib were included in a controlled EORTC/ISG/AGITG (European Organisation for Research and Treatment of Ca...
- Colorectal Cancer Risk Perception on the Basis of Genetic Test Results in Individuals at Risk for Lynch Syndrome
[作者:Grover, S; Stoffel, EM; Mercado, RC; Ford, BM; Kohlman, WK; Shannon, KM; Conrad, PG; Blanco, AM; Terdiman, JP; Gruber, SB; Chung, DC; Syngal, S,期刊:Journal of clinical oncology, 页码:3981-3986 , 文章类型: Article,,卷期:2009年27-24]
- PurposeLynch syndrome is associated with inherited germline mutations in mismatch repair (MMR) genes. Genetic testing in high-risk individuals may yield indeterminate results if no mutation is found or if a mutation of u...
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