- Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency
[作者:Marston, S; Copeland, O; Jacques, A; Livesey, K; Tsang, V; McKenna, WJ; Jalilzadeh, S; Carballo, S; Redwood, C; Watkins, H,期刊:Circulation Research, 页码:219-U39 , 文章类型: Editorial Material,,卷期:2009年105-3]
- Rationale: Most sarcomere gene mutations that cause hypertrophic cardiomyopathy are missense alleles that encode dominant negative proteins. The potential exceptions are mutations in the MYBPC3 gene (encoding cardiac myo...
- G Protein-Coupled Receptor APJ and Its Ligand Apelin Act Downstream of Cripto to Specify Embryonic Stem Cells Toward the Cardiac Lineage Through Extracellular Signal-Regulated Kinase/p70S6 Kinase Signaling Pathway
[作者:D'Aniello, C; Lonardo, E; Iaconis, S; Guardiola, O; Liguoro, AM; Liguori, GL; Autiero, M; Carmeliet, P; Minchiotti, G,期刊:Circulation Research, 页码:231-U65 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: Pluripotent stem cells represent a powerful model system to study the early steps of cardiac specification for which the molecular control is largely unknown. The EGF-CFC (epidermal growth factor-Cripto/FRL-1/...
- Nonsense-Mediated mRNA Decay and Ubiquitin-Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice
[作者:Vignier, N; Schlossarek, S; Fraysse, B; Mearini, G; Kramer, E; Pointu, H; Mougenot, N; Guiard, J; Reimer, R; Hohenberg, H; Schwartz, K; Vernet, M; Eschenhagen, T; Carrier, L,期刊:Circulation Research, 页码:239-U89 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: Mutations in the MYBPC3 gene encoding cardiac myosin-binding protein (cMyBP)-C are frequent causes of hypertrophic cardiomyopathy, but the mechanisms leading from mutations to disease remain elusive. Objective...
- Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells
[作者:Lyle, AN; Deshpande, NN; Taniyama, Y; Seidel-Rogol, B; Pounkova, L; Du, PF; Papaharalambus, C; Lassegue, B; Griendling, KK,期刊:Circulation Research, 页码:249-U116 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: NADPH oxidases (Noxes) regulate vascular physiology and contribute to the pathogenesis of vascular disease. In vascular smooth muscle cells (VSMCs), the interactions of individual Nox homologs with regulatory ...
- Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis
[作者:Zheng, YJ; Vertuani, S; Nystrom, S; Audebert, S; Meijer, I; Tegnebratt, T; Borg, JP; Uhlen, P; Majumdar, A; Holmgren, L,期刊:Circulation Research, 页码:260-U148 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: We have previously shown that angiomotin (Amot) is essential for endothelial cell migration during mouse embryogenesis. However, approximate to 5% of Amot knockout mice survived without any detectable vascular...
- ASIC2a and ASIC3 Heteromultimerize to Form pH-Sensitive Channels in Mouse Cardiac Dorsal Root Ganglia Neurons
[作者:Hattori, T; Chen, J; Harding, AMS; Price, MP; Lu, YJ; Abboud, FM; Benson, CJ,期刊:Circulation Research, 页码:279-U170 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: Acid-sensing ion channels (ASICs) are Na+ channels that are activated by acidic pH. Their expression in cardiac afferents and remarkable sensitivity to small pH changes has made them leading candidates to sens...
- Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice
[作者:Park, HJ; Zhang, YL; Du, CA; Welzig, CM; Madias, C; Aronovitz, MJ; Georgescu, SP; Naggar, I; Wang, B; Kim, YB; Blaustein, RO; Karas, RH; Liao, RL; Mathews, CE; Galper, JB,期刊:Circulation Research, 页码:287-U189 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: Diabetic autonomic neuropathy (DAN), a major complication of diabetes mellitus, is characterized, in part, by impaired cardiac parasympathetic responsiveness. Parasympathetic stimulation of the heart involves ...
- Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice
[作者:Liu, J; Huan, CM; Chakraborty, M; Zhang, HQ; Lu, D; Kuo, MS; Cao, GQ; Jiang, XC,期刊:Circulation Research, 页码:295-U205 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: Sphingomyelin synthase (SMS) 2 contributes to de novo sphingomyelin (SM) biosynthesis and plasma membrane SM levels. SMS2 deficiency in macrophages diminishes nuclear factor kappa B and mitogen-activated prote...
- Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction
[作者:Xu, JW; Ismat, FA; Wang, T; Lu, MM; Antonucci, N; Epstein, JA,期刊:Circulation Research, 页码:304-U222 , 文章类型: Article,,卷期:2009年105-3]
- Rationale: Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder with a broad array of clinical manifestations, including benign and malignant tumors, and characteristic cutaneous findings. NF1 patients ...
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