- Interaction of TFAP2C with the Estrogen Receptor-alpha Promoter Is Controlled by Chromatin Structure
[作者：Woodfield, GW; Hitchler, MJ; Chen, Y; Domann, FE; Weigel, RJ,期刊：Clinical Cancer Research, 页码：3672-3679 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Transcriptional regulation of estrogen receptor-alpha (ER alpha) involves both epigenetic mechanisms and trans-active factors, such as TFAP2C, which induces ER alpha transcription through an AP-2 regulatory regi...
- FOXA1 Is a Potential Oncogene in Anaplastic Thyroid Carcinoma
[作者：Nucera, C; Eeckhoute, J; Finn, S; Carrol, JS; Ligon, AH; Priolo, C; Fadda, G; Toner, M; Sheils, O; Attard, M; Pontecorvi, A; Nose, V; Loda, M; Brown, M,期刊：Clinical Cancer Research, 页码：3680-3689 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: FOXA1 is a mammalian endodermal transcription factor belonging to the human forkhead box gene family that plays a role in certain tumor types. Here, we investigated the potential role of FOXA1 in human thyroid c...
- Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds
[作者：De Preter, K; De Brouwer, S; Van Maerken, T; Pattyn, F; Schramm, A; Eggert, A; Vandesompele, J; Speleman, F,期刊：Clinical Cancer Research, 页码：3690-3696 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Neuroblastoma is a heterogeneous childhood tumor with poor survival outcome for the aggressive type despite intensive multimodal therapies. In this study, we aimed to identify new treatment options for neuroblas...
- Molecular Mechanisms Underlying Effects of Epidermal Growth Factor Receptor Inhibition on Invasion, Proliferation, and Angiogenesis in Experimental Glioma
[作者：Guillamo, JS; de Bouard, S; Valable, S; Marteau, L; Leuraud, P; Marie, Y; Poupon, MF; Parienti, JJ; Raymond, E; Peschanski, M,期刊：Clinical Cancer Research, 页码：3697-3704 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Epidermal growth factor receptor (EGFR) signal transduction pathways are implicated in malignant glioma aggressiveness and promote tumor cell invasion, proliferation, and angiogenesis. Nevertheless, response to ...
- Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes
[作者：Hauswald, S; Duque-Afonso, J; Wagner, MM; Schertl, FM; Lubbert, M; Peschel, C; Keller, U; Licht, T,期刊：Clinical Cancer Research, 页码：3705-3715 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells. Recent reports suggest that the multidrug...
- Therapeutic Efficacy of Seliciclib in Combination with Ionizing Radiation for Human Nasopharyngeal Carcinoma
[作者：Hui, ABY; Yue, SJ; Shi, W; Alajez, NM; Ito, E; Green, SR; Frame, S; O'Sullivan, B; Liu, FF,期刊：Clinical Cancer Research, 页码：3716-3724 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Seliciclib is a small-molecule cyclin-dependent kinase inhibitor, which has been reported to induce apoptosis and cell cycle arrest in EBV-negative nasopharyngeal carcinoma cell lines. Because most nasopharyngea...
- ERBB1 and ERBB2 Have Distinct Functions in Tumor Cell Invasion and Intravasation
[作者：Kedrin, D; Wyckoff, J; Boimel, PJ; Coniglio, SJ; Hynes, NE; Arteaga, CL; Segall, JE,期刊：Clinical Cancer Research, 页码：3733-3739 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: The epidermal growth factor receptor (ERBB1) and related family member HER-2/neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. Clinical ...
- HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer
[作者：Knowles, LM; Stabile, LP; Egloff, AM; Rothstein, ME; Thomas, SM; Gubish, CT; Lerner, EC; Seethala, RR; Suzuki, S; Quesnelle, KM; Morgan, S; Ferris, RL; Grandis, JR; Siegfried, JM,期刊：Clinical Cancer Research, 页码：3740-3750 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: We determined hepatocyte growth factor (HGF) and c-Met expression and signaling in human head and neck squamous cell carcinoma (HNSCC) cells and primary tissues and tested the ability of c-Met tyrosine kinase in...
- Sagopilone Inhibits Breast Cancer Bone Metastasis and Bone Destruction Due to Simultaneous Inhibition of Both Tumor Growth and Bone Resorption
[作者：Strube, A; Hoffmann, J; Stepina, E; Hauff, P; Klar, U; Kakonen, SM,期刊：Clinical Cancer Research, 页码：3751-3759 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Bone metastases have a considerable impact on quality of life in patients with breast and other cancers. Tumors produce osteoclast-activating factors, whereas bone resorption promotes the growth of tumor cells, ...
- Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219
[作者：Tsai, CY; Ray, AS; Tumas, DB; Keating, MJ; Reiser, H; Plunkett, W,期刊：Clinical Cancer Research, 页码：3760-3769 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: GS-9219 is a cell-permeable prodrug of the acyclic nucleotide analogue 9(2-phosphonylmethoxyethyl)guanine (PMEG); the incorporation of the active metabolite PMEG diphosphate (PMEGpp) into DNA results in DNA chai...
- Therapeutic Targeting of ATP7B in Ovarian Carcinoma
[作者：Mangala, LS; Zuzel, V; Schmandt, R; Leshane, ES; Haider, JB; Armaiz-Pena, GN; Spannuth, WA; Tanaka, T; Shahzad, MMK; Lin, YG; Nick, AM; Danes, CG; Lee, JW; Jennings, NB; Vivas-Mejia, PE; Wolf, JK; Coleman, RL; Siddik, ZH; Lopez-Berestein, G; Lutsenko, S; Sood, AK,期刊：Clinical Cancer Research, 页码：3770-3780 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic potential of targeting a critical platinum resistance gene, ATP...
- Nitric Oxide Synthase Inhibition Enhances the Tumor Vascular-Damaging Effects of Combretastatin A-4 3-O-Phosphate at Clinically Relevant Doses
[作者：Tozer, GM; Prise, VE; Lewis, G; Xie, SP; Wilson, I; Hill, SA,期刊：Clinical Cancer Research, 页码：3781-3790 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: The therapeutic potential of combining the prototype tumor vascular-disrupting agent combretastatin A-4 3-O phosphate (CA-4-P) with systemic nitric oxide synthase (NOS) inhibition was; investigated preclinically...
- Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter Gene
[作者：Brader, P; Kelly, KJ; Chen, NH; Yu, YA; Zhang, Q; Zanzonico, P; Burnazi, EM; Ghani, RE; Serganova, I; Hricak, H; Szalay, AA; Fong, Y; Blasberg, RG,期刊：Clinical Cancer Research, 页码：3791-3801 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Oncolytic viral therapy continues to be investigated for the treatment of cancer, and future studies in patients would benefit greatly from a noninvasive modality for assessing virus dissemination, targeting, an...
- Hypermethylated Genes as Biomarkers of Cancer in Women with Pathologic Nipple Discharge
[作者：Fackler, MJ; Rivers, A; Teo, WW; Mangat, A; Taylor, E; Zhang, Z; Goodman, S; Argani, P; Nayar, R; Susnik, B; Sukumar, S; Khan, SA,期刊：Clinical Cancer Research, 页码：3802-3811 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: In a pilot study of women with pathologic nipple discharge (PND) undergoing ductoscopy, we tested quantitative assessment of gene promoter hypermethylation using quantitative multiplex methylation-specific PCR (...
- Serum Peptidome Profiling Revealed Platelet Factor 4 as a Potential Discriminating Peptide Associated with Pancreatic Cancer
[作者：Fiedler, GM; Leichtle, AB; Kase, J; Baumann, S; Ceglarek, U; Felix, K; Conrad, T; Witzigmann, H; Weimann, A; Schutte, C; Hauss, J; Buchler, M; Thiery, J,期刊：Clinical Cancer Research, 页码：3812-3819 , 文章类型： Article，,卷期：2009年15-11]
- Purpose: Mass spectrometry-based serum peptidome profiling is a promising tool to identify novel disease-associated biomarkers, but is limited by preanalytic factors and the intricacies of complex data processing. Theref...
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