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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共35条记录   Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand against Pancreatic Cancer [作者：Zhang, ZW; Huang, YB; Newman, K; Gu, JF; Zhang, XM; Wu, H; Zhao, M; Xianyu, ZQ; Liu, XY,期刊：Clinical Cancer Research, 页码：5154-5160 , 文章类型： Article，,卷期：2009年15-16] Purpose: Pancreatic cancer continues to pose an enormous challenge to clinicians and cancer scientists. Clinical studies show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts a potent and tumor... Vitexins, Nature-Derived Lignan Compounds, Induce Apoptosis and Suppress Tumor Growth [作者：Zhou, YJ; Liu, YE; Cao, JG; Zeng, GY; Shen, C; Li, YL; Zhou, MC; Chen, YD; Pu, WP; Potters, L; Shi, YE,期刊：Clinical Cancer Research, 页码：5161-5169 , 文章类型： Article，,卷期：2009年15-16] Purpose: Lignans such as secoisolariciresinol diglucoside in flaxseed, are metabolizes to bioactive mammalian lignans of END and ENL. Because mammalian lignans have chemical structural similarity to the natural estrog... Phosphoinositide 3-Kinase Mutations in Breast Cancer: A "Good" Activating Mutation? [作者：Di Cosimo, S; Baselga, J,期刊：Clinical Cancer Research, 页码：5017-5019 , 文章类型： Editorial Material，,卷期：2009年15-16] Gain-of-function mutations in the catalytic subunit of phosphoinositicle-3-kinase (PI3KCA) occur frequently in breast cancer. Kalinsky and colleagues show that PI3KCA mutations are associated with favorable clinicopathol... Tumor and Host-Mediated Pathways of Resistance and Disease Progression in Response to Antiangiogenic Therapy [作者：Ebos, JML; Lee, CR; Kerbel, RS,期刊：Clinical Cancer Research, 页码：5020-5025 , 文章类型： Article，,卷期：2009年15-16] Despite early benefits seen in cancer patients treated with antivascular endothelial growth factor (VEGF) pathway-targeted drugs, the clinical benefits obtained in terms of progression-free or overall survival have been ... Epigenetic Deregulation of DNA Repair and Its Potential for Therapy [作者：Hegi, ME; Sciuscio, D; Murat, A; Levivier, M; Stupp, R,期刊：Clinical Cancer Research, 页码：5026-5031 , 文章类型： Article，,卷期：2009年15-16] Epigenetic silencing of essential components of DNA repair pathways is a common event in many tumor types, and comprise O6-methylguanine-DNA methyltransferase (MGMT), human mut L homolog 1 (hMLH1), Werner syndrome gene (... Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2 [作者：Evans, DG; Kalamarides, M; Hunter-Schaedle, K; Blakeley, J; Allen, J; Babovic-Vuskanovic, D; Belzberg, A; Bollag, G; Chen, RH; DiTomaso, E; Golfinos, J; Harris, G; Jacob, A; Kalpana, G; Karajannis, M; Korf, B; Kurzrock, R; Law, M; McClatchey, A; Packer, R; Roehm, P; Rubenstein, A; Slattery, W; Tonsgard, JH; Welling, DB; Widemann, B; Yohay, K; Giovannini, M,期刊：Clinical Cancer Research, 页码：5032-5039 , 文章类型： Article，,卷期：2009年15-16] Purpose: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder associated primarily with bilateral schwannomas seen on the superior vestibular branches of the eighth cranial nerves. Significant morbidity c... Epidermal Growth Factor Receptor Inhibitors and Antiangiogenic Agents for the Treatment of Non-Small Cell Lung Cancer [作者：Horn, L; Sandler, A,期刊：Clinical Cancer Research, 页码：5040-5048 , 文章类型： Review，,卷期：2009年15-16] Non-small cell lung cancer (NSCLC) is a major global health problem and represents the leading cause of cancer-related deaths worldwide. The majority of patients with NSCLC are diagnosed with advanced-stage disease, and ... PIK3CA Mutation Associates with Improved Outcome in Breast Cancer [作者：Kalinsky, K; Jacks, LM; Heguy, A; Patil, S; Drobnjak, M; Bhanot, UK; Hedvat, CV; Traina, TA; Solit, D; Gerald, W; Moynahan, ME,期刊：Clinical Cancer Research, 页码：5049-5059 , 文章类型： Article，,卷期：2009年15-16] Purpose: In breast cancer, somatic mutations in the PIK3CA gene are common. The prognostic implication of these activating mutations remains uncertain as moderately sized studies have yielded variable outcomes. Our aim w... miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy [作者：Adam, L; Zhong, M; Choi, W; Qi, W; Nicoloso, M; Arora, A; Calin, G; Wang, H; Siefker-Radtke, A; McConkey, D; Bar-Eli, M; Dinney, C,期刊：Clinical Cancer Research, 页码：5060-5072 , 文章类型： Article，,卷期：2009年15-16] Purpose: The epithelial-to-mesenchymal transition (EMT) is a cell development-regulated process in which noncoding RNAs act as crucial modulators. Recent studies have implied that EMT may contribute to resistance to epid... MicroRNA-221 Targets Bmf in Hepatocellular Carcinoma and Correlates with Tumor Multifocality [作者：Gramantieri, L; Fornari, F; Ferracin, M; Veronese, A; Sabbioni, S; Calin, GA; Grazi, GL; Croce, CM; Bolondi, L; Negrini, M,期刊：Clinical Cancer Research, 页码：5073-5081 , 文章类型： Article，,卷期：2009年15-16] Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis. Purpose: This study aims to inves... Profiling of Chemonaive Osteosarcoma and Paired-Normal Cells Identifies EBF2 as a Mediator of Osteoprotegerin Inhibition to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis [作者：Patino-Garcia, A; Zalacain, M; Folio, C; Zandueta, C; Sierrasesumaga, L; Julian, MS; Toledo, G; De Las Rivas, J; Lecanda, F,期刊：Clinical Cancer Research, 页码：5082-5091 , 文章类型： Article，,卷期：2009年15-16] Purpose: Osteosarcoma is the most prevalent bone tumor in children and adolescents. At present, the mechanisms of initiation, maintenance, and metastasis are poorly understood. The purpose of this study was to identify r... CIP2A Is Associated with Human Breast Cancer Aggressivity [作者：Come, C; Laine, A; Chanrion, M; Edgren, H; Mattila, E; Liu, XL; Jonkers, J; Ivaska, J; Isola, J; Darbon, JM; Kallioniemi, O; Thezenas, S; Westermarck, J,期刊：Clinical Cancer Research, 页码：5092-5100 , 文章类型： Article，,卷期：2009年15-16] Purpose: To investigate the clinical relevance of the recently characterized human oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) in human breast cancer. Experimental Design: CIP2A expression (mRNA and... Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients [作者：Harradine, KA; Ridd, K; Saunier, EF; Clermont, FF; Perez-Losada, J; Moore, DH; Epstein, EH; Bastian, BC; Akhurst, RJ,期刊：Clinical Cancer Research, 页码：5101-5107 , 文章类型： Article，,卷期：2009年15-16] Purpose: Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ transplantation. Preclinical studies suggest that ARD treatment increases transforming growth f... Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-kB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell-Mediated Cytotoxicity [作者：Boll, B; Eltaib, F; Reiners, KS; von Tresckow, B; Tawadros, S; Simhadri, VR; Burrows, FJ; Lundgren, K; Hansen, HP; Engert, A; von Strandmann, EP,期刊：Clinical Cancer Research, 页码：5108-5116 , 文章类型： Article，,卷期：2009年15-16] Purpose: In Hodgkin's lymphoma, constitutive activation of NF-kB promotes tumor cell survival and proliferation. The molecular chaperone heat shock protein 90 (HSP90) has immune regulatory activity and supports the activ... Inhibition of Insulin-Like Growth Factor 1 Receptor by CP-751,871 Radiosensitizes Non-Small Cell Lung Cancer Cells [作者：Iwasa, T; Okamoto, I; Suzuki, M; Hatashita, E; Yamada, Y; Fukuoka, M; Ono, K; Nakagawa, K,期刊：Clinical Cancer Research, 页码：5117-5125 , 文章类型： Article，,卷期：2009年15-16] Purpose: Therapeutic strategies that target the insulin-like growth factor I receptor (IGF-1R) hold promise for a wide variety of cancers. We have now investigated the effect of CP-751,871, a fully human monoclonal antib... MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells [作者：Lee, CYF; Rennie, PS; Jia, WWG,期刊：Clinical Cancer Research, 页码：5126-5135 , 文章类型： Article，,卷期：2009年15-16] Purpose: Advanced castration-resistant prostate cancer, for which there are few treatment options, remains one of the leading causes of cancer death. MicroRNAs (miRNA) have provided a new opportunity for more stringent r...