- The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-MDM2 protein-protein interaction
[作者:Clark, RC; Lee, SY; Searcey, M; Boger, DL,期刊:Natural Product Reports , 页码:465-477 , 文章类型: Review,,卷期:2009年26-4]
- Inhibitors of key protein-protein interactions are emerging as exciting therapeutic targets for the treatment of cancer. One such interaction between MDM2 (HDM2) and p53, that silences the tumour suppression activities o...
- Rediscovering the bioactivity and ecological role of 1,4-benzoxazinones
[作者:Macias, FA; Marin, D; Oliveros-Bastidas, A; Molinillo, JMG,期刊:Natural Product Reports , 页码:478-489 , 文章类型: Review,,卷期:2009年26-4]
- Compounds of the (2H)-1,4-benzoxazin-3(4H)-one class have attracted the attention of phytochemists since the first isolation of 2,4-dihydroxy- 2H-1,4-benzoxazin-3(4H)-one(DIBOA) and 2,4-dihydroxy-7methoxy-(2H)-1,4-benzox...
- Biosynthesis of insect spiroacetals
[作者:Booth, YK; Kitching, W; De Voss, JJ,期刊:Natural Product Reports , 页码:490-525 , 文章类型: Review,,卷期:2009年26-4]
- The volatile secretions of numerous species of Coleoptera (beetles), Hymenoptera (wasps, bees) and Diptera (true flies) contain complex blends of spiroacetals. In several species, a certain number of them appear to funct...
- Conotoxins: natural product drug leads
[作者:Halai, R; Craik, DJ,期刊:Natural Product Reports , 页码:526-536 , 文章类型: Review,,卷期:2009年26-4]
- Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thoug...
- Challenges in the synthesis of a unique mono-carboxylic acid antibiotic, (+)-zincophorin
[作者:Song, ZL; Lohse, AG; Hsung, RP,期刊:Natural Product Reports , 页码:560-571 , 文章类型: Review,,卷期:2009年26-4]
- (+)-Zincophorin, also referred to as M144255 or griseocholin, is a polyoxygenated ionophoric antibiotic that was isolated from Streptomyces griseus in 1984. It possesses strong in vivo activity against Gram-positive bact...
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