- Aortic stiffness in diabetes mellitus - association with glutamine and heat shock protein 70 expression: a pilot study based on an experimental rodent model
[作者:Ugurlucan, M; Erer, D; Kalko, Y; Gungor, F; Haholu, A; Basaran, M; Banach, M; Rysz, J; Mikhailidis, DP; Tireli, E; Dayioglu, E; Alpagur, U,期刊:Expert Opinion on Therapeutic Targets, 页码:267-274 , 文章类型: Article,,卷期:2009年13-3]
- Background: Diabetes mellitus (DM) alters arterial wall compliance and causes aortic stiffness, which is a predictor of vascular mortality. Heat shock proteins (HSPs) are involved in the protection of cells under stress....
- HSP 70 and atherosclerosis protector - or activator?
[作者:Bielecka-Dabrowa, A; Barylski, M; Mikhailidis, DP; Rysz, J; Banach, M,期刊:Expert Opinion on Therapeutic Targets, 页码:307-317 , 文章类型: Review,,卷期:2009年13-3]
- Background: Atherosclerosis and its complications represent the leading cause of morbidity and mortality. Heat shock protein 70 (HSP70) protects cellular elements from injury by reducing oxidation, inflammation and apopt...
- Mechanisms of tumor resistance to EGFR-targeted therapies
[作者:Hopper-Borge, EA; Nasto, RE; Ratushny, V; Weiner, LM; Golemis, EA; Astsaturov, I,期刊:Expert Opinion on Therapeutic Targets, 页码:339-362 , 文章类型: Review,,卷期:2009年13-3]
- Background: Much effort has been devoted to development of cancer therapies targeting EGFR, based on its role in regulating cell growth. Small-molecule and antibody EGFR inhibitors have clinical roles based on their effi...
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