Expert Opinion on Therapeutic Targets————————个性化文献订阅—

Identifying targets for drug discovery using bioinformatics
[作者：Chen, YPP; Chen, F,期刊：Expert Opinion on Therapeutic Targets, 页码：383-389 , 文章类型： Editorial Material，,卷期：2008年12-4]
Background: Drug discovery is the process of discovering and designing drugs, which includes target identification, target validation, lead identification, lead optimization and introduction of the new drugs to the publi...

New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B
[作者：Huang, YH; Hoebe, K; Sauer, K,期刊：Expert Opinion on Therapeutic Targets, 页码：391-413 , 文章类型： Review，,卷期：2008年12-4]
Background: Sequencing of the murine and human genomes has enabled large-scale functional genomics approaches to target identification. This holds the promise of drastically accelerating target discovery. Moreover, by pr...

Cysteinyl leukotriene receptor CysLT(1) as a novel therapeutic target for allergic rhinitis treatment
[作者：Shirasaki, H,期刊：Expert Opinion on Therapeutic Targets, 页码：415-423 , 文章类型： Review，,卷期：2008年12-4]
Background: Cysteinyl leukotrienes (cys-LTs) play an important role in allergic rhinitis because CysLT(1) receptor antagonists relieve the symptoms of allergic rhinitis. Objective: I overview the clinical pharmacology of...

Potential therapeutic targets for Parkinsons disease
[作者：Stoessl, AJ,期刊：Expert Opinion on Therapeutic Targets, 页码：425-436 , 文章类型： Review，,卷期：2008年12-4]
Background: Parkinson's disease is a common disorder that becomes more prevalent with advanced age. The cardinal features are related to dopamine deficiency, arising from loss of neurons projecting from the substantia ni...

Neurotrophic factors as a therapeutic target for Parkinson's disease
[作者：Evans, JR; Barker, RA,期刊：Expert Opinion on Therapeutic Targets, 页码：437-447 , 文章类型： Review，,卷期：2008年12-4]
Background: The search for therapeutic agents that might alter the disease course in Parkinson's disease (PD) is ongoing. One area of particular interest involves neurotrophic factors (NTFs), with those of the glial cell...

Therapeutic targets for medulloblastoma
[作者：Wlodarski, PK; Jozwiak, J,期刊：Expert Opinion on Therapeutic Targets, 页码：449-461 , 文章类型： Review，,卷期：2008年12-4]
Background: Present treatment of medulloblastoma, the most common malignant brain tumor in children, includes surgery, radiotherapy and chemotherapy. In spite of radical treatment, only about 70% of patients survive. Als...

Targeting survivin in cancer therapy
[作者：Pennati, M; Folini, M; Zaffaroni, N,期刊：Expert Opinion on Therapeutic Targets, 页码：463-476 , 文章类型： Review，,卷期：2008年12-4]
Background: Survivin is a structurally unique member of the inhibitor of protein (IAP) family that acts as a suppressor of apoptosis and plays a central role in cell division. Owing to its massive upregulation in human t...

Targeting the TCR signaling checkpoint: a therapeutic strategy to reactive memory T cells in the tumor microenvironment
[作者：Simpson-Abelson, MR; Bankert, RB,期刊：Expert Opinion on Therapeutic Targets, 页码：477-490 , 文章类型： Review，,卷期：2008年12-4]
Background: One of the major conundrums in cancer immunotherapy is why human tumors are not rejected, and progress despite the presence of inflammatory leukocytes in the tumor microenvironment. While studies addressing t...

ABCA2 as a therapeutic target in cancer and nervous system disorders
[作者：Mack, JT; Brown, CB; Tew, KD,期刊：Expert Opinion on Therapeutic Targets, 页码：491-504 , 文章类型： Review，,卷期：2008年12-4]
Background: Overexpression of ATP-binding cassette (ABC) transporters is a major adaptive advantage used by tumor cells to evade the accumulation of cytotoxic agents. ABCA2, a transporter highly expressed in the cells of...

The yeast two-hybrid system and its role in drug discovery
[作者：Nicolas, L; Auerbach, D,期刊：Expert Opinion on Therapeutic Targets, 页码：505-515 , 文章类型： Review，,卷期：2008年12-4]
Background: The yeast two-hybrid system is the most widely used genetic assay to identify and characterize novel protein interactions. Over the past decade, the system has been adapted to cover an increasingly wide range...