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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Serum total homocysteine, folate, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C -> T genotype and subclinical atherosclerosis [作者：Panayiotou, A; Nicolaides, A; Griffin, M; Tyllis, T; Georgiou, N; Martin, RM; Bond, D; Tziakouri-Shiakalli, C; Fessas, C; Deltas, C,期刊：Expert Opinion on Therapeutic Targets, 页码：1-11 , 文章类型： Article，,卷期：2009年13-1] Objective: To determine the relationship of serum total homocysteine (tHcy), serum folate and 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C -> T genotype with ultrasonic arterial wall measurements associated with... Defining protein interactions that regulate disease progression [作者：Al-Khoury, R; Coulombe, B,期刊：Expert Opinion on Therapeutic Targets, 页码：13-17 , 文章类型： Editorial Material，,卷期：2009年13-1] Over the past few years, the study of protein-protein interactions and protein complexes has shed more light on cellular processes and cell function. Because alterations in protein-protein interactions perturb the normal... PCSK9 as a therapeutic target of dyslipidemia [作者：Seidah, NG,期刊：Expert Opinion on Therapeutic Targets, 页码：19-28 , 文章类型： Review，,卷期：2009年13-1] Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), which promotes degradation of hepatic low density lipoprotein receptor (LDLR), has a role in plasma cholesterol metabolism. Its gene is associated with t... Vitamin D and the vasculature: can we teach an old drug new tricks? [作者：Valdivielso, JM; Coll, B; Fernandez, E,期刊：Expert Opinion on Therapeutic Targets, 页码：29-38 , 文章类型： Review，,卷期：2009年13-1] Background: Vitamin D is a steroid hormone known for its role in regulating levels of calcium and phosphorus. Vitamin D has important autocrine/paracrine roles and it is involved in vascular biology. Clinical studies hav... The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury [作者：van der Heijden, M; Amerongen, GPV; Chedamni, S; van Hinsbergh, VWM; Groeneveld, ABJ,期刊：Expert Opinion on Therapeutic Targets, 页码：39-53 , 文章类型： Review，,卷期：2009年13-1] Background: Sepsis and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are life-threatening syndromes characterised by inflammation and increased vascular permeability. Amongst other factors, the angio... Regulation of the Na+/H+ exchanger in the healthy and diseased myocardium [作者：Fliegel, L,期刊：Expert Opinion on Therapeutic Targets, 页码：55-68 , 文章类型： Review，,卷期：2009年13-1] Background: Na+/H+ exchangers (NHE's) are membrane proteins that regulate ion fluxes, they extrude one intracellular proton in exchange for one extracellular sodium thereby regulating intracellular pH. Mammalian NHE's ha... TRP channels as emerging targets for pain therapeutics [作者：Broad, LM; Mogg, AJ; Beattie, RE; Ogden, AM; Blanco, MJ; Bleakman, D,期刊：Expert Opinion on Therapeutic Targets, 页码：69-81 , 文章类型： Review，,卷期：2009年13-1] Background: The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by te... Protein kinase A as a biological target in cancer therapy [作者：Naviglio, S; Caraglia, M; Abbruzzese, A; Chiosi, E; Di Gesto, D; Marra, M; Romano, M; Sorrentino, A; Sorvillo, L; Spina, A; Illiano, G,期刊：Expert Opinion on Therapeutic Targets, 页码：83-92 , 文章类型： Review，,卷期：2009年13-1] Background: cAMP is a second messenger that plays a role in intracellular signal transduction of various stimuli. a major function of cAMP in eukaryotes is activation of cAMP-dependent protein kinase (PKA). PKA is the be... Melanoma: targeting signaling pathways and RaLP [作者：Pasini, L; Turco, MY; Luzi, L; Aladowicz, E; Fagiani, E; Lanfrancone, L,期刊：Expert Opinion on Therapeutic Targets, 页码：93-104 , 文章类型： Review，,卷期：2009年13-1] Background: Metastatic melanoma remains one of the most aggressive forms of cancer, with a survival expectation of above six months only in rare cases. Despite advances in the characterization of the underlying molecular... Trypanosoma cruzi targets for new chemotherapeutic approaches [作者：Soeiro, MNC; de Castro, SL,期刊：Expert Opinion on Therapeutic Targets, 页码：105-121 , 文章类型： Review，,卷期：2009年13-1] Background: Strategies for development of anti-parasite chemotherapy involve identification of active principles of plants, investigation of drugs already licensed for other pathologies, or validation of specific targets... Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism [作者：Tsialogiannis, E; Polyzois, I; Tang, QO; Pavlou, G; Tsiridis, E; Heliotis, M; Tsiridis, E,期刊：Expert Opinion on Therapeutic Targets, 页码：123-137 , 文章类型： Review，,卷期：2009年13-1] Background: Bone morphogenetic proteins (BMPs) and their antagonists are involved in fracture healing. Antagonists regulate BMPs by blocking signal transduction or interfering with transcription factors at the nucleus. O...