- Nuclear Localization of Cell-Penetrating Peptides Is Dependent on Endocytosis Rather Than Cytosolic Delivery in CHO Cells
[作者：Zaro, JL; Vekich, JE; Tran, T; Shen, WC,期刊：Molecular Pharmaceutics, 页码：337-344 , 文章类型： Article，,卷期：2009年6-2]
The nuclear localization of various cell penetrating peptides (CPPs), including Tat (47-57], YG(R)(9), YG(K)(9), and model amphipathic peptide (MAP), was examined and correlated with the endocytosis and cytosolic tran...
- Immunological Effects and Membrane Interactions of Chitosan Nanoparticles
[作者：Pattani, A; Patravale, VB; Panicker, L; Potdar, PD,期刊：Molecular Pharmaceutics, 页码：345-352 , 文章类型： Article，,卷期：2009年6-2]
- The objective of this study was to investigate the in vitro and in vivo effects of blank chitosan nanoparticles on various molecular markers such as nitric oxide (NO) production, IL-6 gene expression, and lymphocyte prol...
- Insulin-Loaded Microcapsules for In Vivo Delivery
[作者：Kim, BS; Oh, JM; Hyun, H; Kim, KS; Lee, SH; Kim, YH; Park, K; Lee, HB; Kim, MS,期刊：Molecular Pharmaceutics, 页码：353-365 , 文章类型： Article，,卷期：2009年6-2]
- Microencapsulation of insulin has been difficult, due to the high sensitivity of insulin to the harsh conditions that can occur during the microencapsulation process. We have developed a method of preparing insulin-loade...
- Scavenger Receptor A: A New Route for Adenovirus 5
[作者：Haisma, HJ; Boesjes, M; Beerens, AM; van der Strate, BWA; Curiel, DT; Pluddemann, A; Gordon, S; Bellu, AR,期刊：Molecular Pharmaceutics, 页码：366-374 , 文章类型： Article，,卷期：2009年6-2]
Adenoviruses are common pathogens associated with respiratory diseases, gastrointestinal illnesses and/or conjunctivitis. Currently, this virus is used as a vector in gene therapy trials. The promise of viral gene the...
- Fluorophore-Quencher Based Activatable Targeted Optical Probes for Detecting in Vivo Cancer Metastases
[作者：Ogawa, M; Kosaka, N; Longmire, MR; Urano, Y; Choyke, PL; Kobayashi, H,期刊：Molecular Pharmaceutics, 页码：386-395 , 文章类型： Article，,卷期：2009年6-2]
- In vivo molecularly targeted fluorescence imaging of tumors has been proposed as a strategy for improving cancer detection and management. Activatable fluorophores, which increased their fluorescence by 10-fold after bin...
- Effect of Modification of the Physicochemical Properties of ICAM-1-Derived Peptides on Internalization and Intracellular Distribution in the Human Leukemic Cell Line HL-60
[作者：Majumdar, S; Tejo, BA; Badawi, AH; Moore, D; Krise, JP; Siahaan, TJ,期刊：Molecular Pharmaceutics, 页码：396-406 , 文章类型： Article，,卷期：2009年6-2]
- The objective of this work is to test the hypothesis that increasing the hydrophilicity of DOX-peptide conjugates may modify their entry mechanisms into HL-60 cells from passive diffusion to receptor-mediated uptake. To ...
- Highly Supersaturated Solutions from Dissolution of Amorphous Itraconazole Microparticles at pH 6.8
[作者：Matteucci, ME; Paguio, JC; Miller, MA; Williams, RO; Johnston, KP,期刊：Molecular Pharmaceutics, 页码：375-385 , 文章类型： Article，,卷期：2009年6-2]
- Dry powders from aqueous dispersions, formed by antisolvent precipitation, dissolved to form solutions with supersaturation values up to 12 in 10 min at pH 6.8 with sodium dodecyl sulfate micelles. Itraconazole/hydroxypr...
- Characterization of PLGA Nanospheres Stabilized with Amphiphilic Polymers: Hydrophobically Modified Hydroxyethyl Starch vs Pluronics
[作者：Besheer, A; Vogel, J; Glanz, D; Kressler, J; Groth, T; Mader, K,期刊：Molecular Pharmaceutics, 页码：407-415 , 文章类型： Article，,卷期：2009年6-2]
- Some Pluronics, particularly F127, are known to stabilize nanospheres and prolong their circulation time in vivo. However, these copolymers of poly(ethylene glycol) (PEG) and poly(propylene glycol) are not biodegradable,...
- Conjugation with Cationic Cell-Penetrating Peptide Increases Pulmonary Absorption of Insulin
[作者：Patel, EN; Wang, J; Kim, KJ; Borok, Z; Crandall, ED; Shen, WC,期刊：Molecular Pharmaceutics, 页码：492-503 , 文章类型： Article，,卷期：2009年6-2]
- In this study, we determined if cell-penetrating peptides (CPPs) can be used to enhance the absorption rate of insulin (INS) across the alveolar epithelial barrier. Using a heterobifunctional cross-linker, INS was conjug...
- Nitroxyl Radicals for Labeling of Conventional Therapeutics and Noninvasive Magnetic Resonance Imaging of Their Permeability for Blood-Brain Barrier: Relationship between Structure, Blood Clearance, and MRI Signal Dynamic in the Brain
[作者：Zhelev, Z; Balkalova, R; Aoki, L; Matsumoto, K; Gadjeva, V; Anzai, K; Kanno, I,期刊：Molecular Pharmaceutics, 页码：504-512 , 文章类型： Article，,卷期：2009年6-2]
- The present study describes a novel nonradioactive methodology for in vivo noninvasive, real-time imaging of blood-brain barrier (BBB) permeability for conventional drugs, using nitroxyl radicals as spin-labels and magne...
- N-Hydroxy-7-(2-naphthylthio) Heptanomide Inhibits Retinal and Choroidal Angiogenesis
[作者：Kim, JH; Kim, JH; Oh, M; Yu, YS; Kim, KW; Kwon, HJ,期刊：Molecular Pharmaceutics, 页码：513-519 , 文章类型： Article，,卷期：2009年6-2]
- Histone deacetylase (HDAC) is a key enzyme regulating gene expression, including angiogenic cytokine expression. We have previously identified a novel synthetic HDAC inhibitor, known as N-hydroxy-7-(2-naphthylthio) hepta...
- Tumor Targeting of Functionalized Quantum Dot-Liposome Hybrids by Intravenous Administration
[作者：All-Jamal, WT; Al-Jamal, KT; Tian, B; Cakebread, A; Halket, JM; Kostarelos, K,期刊：Molecular Pharmaceutics, 页码：520-530 , 文章类型： Article，,卷期：2009年6-2]
- A strategy to target functionalized quantum clot-liposome (f-QD-L) hybrid vesicles in the solid tumor tissue of tumor-bearing mice is explored. Functionalized polyethylene glycol (PEG)lipid coated QD (f-QD) were encapsul...
- Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing. A Preliminary Study
[作者：Brufani, M; Ceccacci, F; Filocamo, L; Garofalo, B; Joudioux, R; La Bella, A; Leonelli, F; Migneco, LM; Bettolo, RM; Farina, PM; Ashcroft, GS; Routley, C; Hardman, M; Meda, C; Rando, G; Maggi, A,期刊：Molecular Pharmaceutics, 页码：543-556 , 文章类型： Article，,卷期：2009年6-2]
- New 17 beta-estradiol (E-2) derivatives 1-11 were synthesized from an estrone derivative by addition of organometallic reagents prepared from protected alpha,omega-alkynols and further elaboration of the addition product...
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