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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共27条记录   Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 [作者：Kang, BH; Plescia, J; Song, HY; Meli, M; Colombo, G; Beebe, K; Scroggins, B; Neckers, L; Altieri, DC,期刊：Journal of clinical investigation, 页码：454-464 , 文章类型： Article，,卷期：2009年119-3] Although therapeutically targeting a single signaling pathway that drives tumor development and/or progression has been effective for a number of cancers, in many cases this approach has not been successful. Targeting ne... Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice [作者：Bending, D; De La Pena, H; Veldhoen, M; Phillips, JM; Uyttenhove, C; Stockinger, B; Cooke, A,期刊：Journal of clinical investigation, 页码：565-572 , 文章类型： Article，,卷期：2009年119-3] Th17 cells are involved in. the pathogenesis of many autoimmune diseases, but it is not clear whether they play a pathogenic role in type I diabetes. Here we investigated whether mouse Th17 cells with specificity for an ... Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans [作者：Anderson, EJ; Lustig, ME; Boyle, KE; Woodlief, TL; Kane, DA; Lin, CT; Price, JW; Kang, L; Rabinovitch, PS; Szeto, HH; Houmard, JA; Cortright, RN; Wasserman, DH; Neufer, PD,期刊：Journal of clinical investigation, 页码：573-581 , 文章类型： Article，,卷期：2009年119-3] High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been imp... Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression [作者：Yoo, BK; Emdad, L; Su, Z; Villanueva, A; Chiang, DY; Mukhopadhyay, ND; Mills, AS; Waxman, S; Fisher, RA; Llovet, JM; Fisher, PB; Sarkar, D,期刊：Journal of clinical investigation, 页码：465-477 , 文章类型： Article，,卷期：2009年119-3] Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by diverse etiology, activation of multiple signal transduction pathways, and various gene mutations. Here, we have determined a specifi... Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer [作者：Ma, JH; DeFrances, MC; Zou, CB; Johnson, C; Ferrell, R; Zarnegar, R,期刊：Journal of clinical investigation, 页码：478-491 , 文章类型： Article，,卷期：2009年119-3] The HGF gene is transcriptionally silenced in normal differentiated breast epithelial cells, but its repression fails to occur in mammary carcinoma tissues and cell lines. The molecular mechanisms underpinning aberrant H... Adenosine signaling contributes to ethanol-induced fatty liver in mice [作者：Peng, Z; Borea, PA; Wilder, T; Yee, H; Chiriboga, L; Blackburn, MR; Azzena, G; Resta, G; Cronstein, BN,期刊：Journal of clinical investigation, 页码：582-594 , 文章类型： Article，,卷期：2009年119-3] Fatty liver is commonly associated with alcohol ingestion and abuse. While the molecular pathogenesis of these fatty changes is well understood, the biochemical and pharmacological mechanisms by which ethanol stimulates ... The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice [作者：Greenshields, KN; Halstead, SK; Zitman, FMP; Rinaldi, S; Brennan, KM; O'Leary, C; Chamberlain, LH; Easton, A; Roxburgh, J; Pediani, J; Furukawa, K; Furukawa, K; Goodyear, CS; Plomp, JJ; Willison, HJ,期刊：Journal of clinical investigation, 页码：595-610 , 文章类型： Article，,卷期：2009年119-3] Anti-GM1 anglioside autoantibodies are used as diagnostic markers for motor axonal peripheral neuropathies and are believed to be the primary mediators of such diseases. However, their ability to bind and exert pathogeni... MT1-MMP and RECK are involved in human CD34(+) progenitor cell retention, egress, and mobilization [作者：Vagima, Y; Avigdor, A; Goichberg, P; Shivtiel, S; Tesio, M; Kalinkovich, A; Golan, K; Dar, A; Kollet, O; Petit, I; Perl, O; Rosenthal, E; Resnick, I; Hardan, I; Gellman, YN; Naor, D; Nagler, A; Lapidot, T,期刊：Journal of clinical investigation, 页码：492-503 , 文章类型： Article，,卷期：2009年119-3] The mechanisms governing hematopoietic progenitor cell mobilization are not fully understood. We report higher membrane type 1-MMP (MT1-MMP) and lower expression of the MT1-MMP inhibitor, reversion-inducing cysteine-rich... Eptifibatide-induced thrombocytopenia and thrombosis in humans require Fc gamma RIIa and the integrin beta 3 cytoplasmic domain [作者：Gao, C; Boylan, B; Bougie, D; Gill, JC; Birenbaum, J; Newman, DK; Aster, RH; Newman, PJ,期刊：Journal of clinical investigation, 页码：504-511 , 文章类型： Article，,卷期：2009年119-3] Thrombocytopenia and thrombosis following treatment with the integrin alpha IIb beta 3 antagonist eptifibatide are rare complications caused by patient antibodies specific for ligand-occupied alpha IIb beta 3. Whether su... Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress [作者：Dorrell, MI; Aguilar, E; Jacobson, R; Yanes, O; Gariano, R; Heckenlively, J; Banin, E; Ramirez, GA; Gasmi, M; Bird, A; Siuzdak, G; Friedlander, M,期刊：Journal of clinical investigation, 页码：611-623 , 文章类型： Article，,卷期：2009年119-3] In several disease states, abnormal growth of blood vessels is associated with local neuronal degeneration. This is particularly true in ocular diseases such as retinal angiomatous proliferation (RAP) and macular telangi... Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy [作者：Lai, Y; Thomas, GD; Yue, YP; Yang, HT; Li, DJ; Long, C; Judge, L; Bostick, B; Chamberlain, JS; Terjung, RL; Duan, DS,期刊：Journal of clinical investigation, 页码：624-635 , 文章类型： Article，,卷期：2009年119-3] Sarcolemma-associated neuronal NOS (nNOS) plays a critical role in normal muscle physiology. In Duchenne muscular dystrophy (DMD), the loss of sarcolemmal nNOS leads to functional ischemia and muscle damage; however, the... Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents [作者：Izikki, M; Guignabert, C; Fadel, E; Humbert, M; Tu, L; Zadigue, P; Dartevelle, P; Simonneau, G; Adnot, S; Maitre, B; Raffestin, B; Eddahibi, S,期刊：Journal of clinical investigation, 页码：512-523 , 文章类型： Article，,卷期：2009年119-3] Pulmonary hypertension (PH) is a progressive, lethal lung disease characterized by pulmonary artery SMC (PA-SMC) hyperplasia. leading to right-sided heart failure. Molecular events originating in pulmonary ECs (P-ECs) ma... Disruption of the Ang II type 1 receptor promotes longevity in mice [作者：Benigni, A; Corna, D; Zoja, C; Sonzogni, A; Latini, R; Salio, M; Conti, S; Rottoli, D; Longaretti, L; Cassis, P; Morigi, M; Coffman, TM; Remuzzi, G,期刊：Journal of clinical investigation, 页码：524-530 , 文章类型： Article，,卷期：2009年119-3] The renin-angiotensin system plays a role in the etiology of hypertension and the pathophysiology of cardiac and renal diseases in humans. Ang II is the central product of this system and is involved in regulating immune... Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice [作者：Qatanani, M; Szwergold, NR; Greaves, DR; Ahima, RS; Lazar, MA,期刊：Journal of clinical investigation, 页码：531-539 , 文章类型： Article，,卷期：2009年119-3] Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies investigating the link between resistin and metabolic disease are conflicting. Further complicating the matter, human r... Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease [作者：Borchers, MT; Wesselkamper, SC; Curull, V; Ramirez-Sarmiento, A; Sanchez-Font, A; Garcia-Aymerich, J; Coronell, C; Lloreta, J; Agusti, AG; Gea, J; Howington, JA; Reed, MF; Starnes, SL; Harris, NL; Vitucci, M; Eppert, BL; Motz, GT; Fogel, K; McGraw, DW; Tichelaar, JW; Orozco-Levi, M,期刊：Journal of clinical investigation, 页码：636-649 , 文章类型： Article，,卷期：2009年119-3] Chronic obstructive pulmonary disease (COPD) is a lethal progressive lung disease culminating in permanent airway obstruction and alveolar enlargement. Previous studies suggest CTL involvement in COPD progression; howeve... Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation [作者：Xiong, H; Wang, DL; Chen, LN; Choo, YS; Ma, H; Tang, CY; Xia, K; Jiang, W; Ronai, Z; Zhuang, XX; Zhang, ZH,期刊：Journal of clinical investigation, 页码：650-660 , 文章类型： Article，,卷期：2009年119-3] Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset familial forms of Parkinson disease (PD). Although mutations in these genes lead to the sam...