- Mice With Hyperghrelinemia Are Hyperphagic and Glucose Intolerant and Have Reduced Leptin Sensitivity
[作者：Bewick, GA; Kent, A; Campbell, D; Patterson, M; Ghatei, MA; Bloom, SR; Gardiner, JV,期刊：Diabetes, 页码：840-846 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Ghrelin is the only known peripheral hormone to increase ingestive behavior. However, its role in the physiological regulation of energy homeostasis is unclear because deletion of ghrelin or its receptor does n...
- Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice
[作者：Hwang, JH; Kim, DW; Jo, EA; Kim, YK; Jo, YS; Park, JH; Yoo, SK; Park, MK; Kwak, TH; Kho, YL; Han, J; Choi, HS; Lee, SH; Kim, JM; Lee, I; Kyung, T; Jang, C; Chung, JK; Kweon, GR; Shong, M,期刊：Diabetes, 页码：965-974 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Nicotinamide adenine dinucleotides (NAD(+) and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD(+)-to-NADH ratio is implicated in metabolic syndrome. However, it is still unknown ...
- Protective Effect of Perindopril on Diabetic Retinopathy Is Associated With Decreased Vascular Endothelial Growth Factor-to-Pigment Epithelium-Derived Factor Ratio Involvement of a Mitochondria-Reactive Oxygen Species Pathway
[作者：Zheng, Z; Chen, HB; Ke, GJ; Fan, Y; Zou, HD; Sun, XD; Gu, Q; Xu, X; Ho, PCP,期刊：Diabetes, 页码：954-964 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-This study aimed to verify whether the decreased vascular endothelial growth factor (VEGF)-to-pigment epithelium-derived factor (PEDF) ratio can serve as an indicator for the protective effect of angiotensin-co...
- Do Non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children With High-Risk HLA-DR,DQ Genotypes?
[作者：Steck, AK; Zhang, W; Bugawan, TL; Barriga, KJ; Blair, A; Erlich, HA; Eisenbarth, GS; Norris, JM; Rewers, MJ,期刊：Diabetes, 页码：1028-1033 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Specific alleles of non-HLA genes INS, CTLA-4, and PTPN22 have been associated with type I diabetes. We examined whether some of these alleles influence development of islet autoimmunity or progression from per...
- Rapamycin Prevents and Breaks the Anti-CD3-Induced Tolerance in NOD Mice
[作者：Valle, A; Jofra, T; Stabilini, A; Atkinson, M; Roncarolo, MG; Battaglia, M,期刊：Diabetes, 页码：875-881 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Non-Fe-binding anti-CD3-specific antibodies represent a promising therapy for preserving C-peptide production in subjects with recent-onset type 1 diabetes. However, the mechanisms by which anti-CD3 exerts its ...
- Relationship of Metabolic Syndrome With Incident Aortic Valve Calcium and Aortic Valve Calcium Progression The Multi-Ethnic Study of Atherosclerosis (MESA)
[作者：Katz, R; Budoff, MJ; Takasu, J; Shavelle, DM; Bertoni, A; Blumenthal, RS; Ouyang, P; Wong, ND; O'Brien, KD,期刊：Diabetes, 页码：813-819 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Metabolic syndrome (MetS) has been associated with increased prevalence of aortic valve calcium (AVC) and with increased progression of aortic stenosis. The purpose of this study was to determine whether MetS i...
- Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity
[作者：Ahmadian, M; Duncan, RE; Varady, KA; Frasson, D; Hellerstein, MK; Birkenfeld, AL; Samuel, VT; Shulman, GI; Wang, YH; Kang, CH; Sul, HS,期刊：Diabetes, 页码：855-866 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-To investigate the role of desnutrin in adipose tissue triacylglycerol (TAG) and fatty acid metabolism. RESEARCH DESIGN AND METHODS-We generated transgenic mice overexpressing desnutrin (also called adipose tri...
- Functional Characterization of Promoter Variants of the Adiponectin Gene Complemented by Epidemiological Data
[作者：Laumen, H; Saningong, AD; Heid, IM; Hess, J; Herder, C; Claussnitzer, M; Baumert, J; Lamina, C; Rathmann, W; Sedlmeier, EM; Klopp, N; Thorand, B; Wichmann, HE; Illig, T; Hauner, H,期刊：Diabetes, 页码：984-991 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Adiponectin (APM1, ACDC) is an adipocyte-derived protein with downregulated expression in obesity and insulin-resistant states. Several potentially regulatory single nucleotide polymorphisms (SNPs) within the A...
- Successful Versus Failed Adaptation to High-Fat Diet-Induced Insulin Resistance The Role of IAPP-Induced beta-Cell Endoplasmic Reticulum Stress
[作者：Matveyenko, AV; Gurlo, T; Daval, M; Butler, AE; Butler, PC,期刊：Diabetes, 页码：906-916 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Obesity is a known risk factor for type 2 diabetes. However, most obese individuals do not develop diabetes because they adapt to insulin resistance by increasing beta-cell mass and insulin secretion. Islet pat...
- Functional ENTPD1 Polymorphisms in African Americans With Diabetes and End-Stage Renal Disease
[作者：Friedman, DJ; Talbert, ME; Bowden, DW; Freedman, BI; Mukanya, Y; Enjyoji, K; Robson, SC,期刊：Diabetes, 页码：999-1006 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation in ENTPD1 influences predisposition to diabet...
- Survey of the Human Pancreatic beta-Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D-1 in Enhancing Human beta-Cell Replication and Function In Vivo
[作者：Fiaschi-Taesch, N; Bigatel, TA; Sicari, B; Takane, KK; Salim, F; Velazquez-Garcia, S; Harb, G; Selk, K; Cozar-Castellano, I; Stewart, AF,期刊：Diabetes, 页码：882-893 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVES-To comprehensively inventory the proteins that control the G1/S cell cycle checkpoint in the human islet and compare them with those in the murine islet, to determine whether these might therapeutically enhanc...
- TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet beta-Cells
[作者：Xavier, GD; Loder, MK; McDonald, A; Tarasov, AI; Carzaniga, R; Kronenberger, K; Barg, S; Rutter, GA,期刊：Diabetes, 页码：894-905 , 文章类型： Article，,卷期：2009年58-4]
- OBJECTIVE-Polymorphisms in the human TCF7L2 gene are associated with reduced insulin secretion and an increased risk of type 2 diabetes. However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear....
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